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mutLBSgeneDB |
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| Gene summary for QPRT |
 Gene summary |
| Basic gene Info. | Gene symbol | QPRT |
| Gene name | quinolinate phosphoribosyltransferase | |
| Synonyms | HEL-S-90n|QPRTase | |
| Cytomap | UCSC genome browser: 16p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014298.3, | |
| Description | QAPRTaseepididymis secretory sperm binding protein Li 90nnicotinate-nucleotide pyrophosphorylase (carboxylating)nicotinate-nucleotide pyrophosphorylase [carboxylating] | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606248 | |
| HGNC : HGNC | ||
| HPRD : 06950 | ||
| Protein | UniProt: Q15274 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_QPRT | |
| BioGPS: 23475 | ||
| Pathway | NCI Pathway Interaction Database: QPRT | |
| KEGG: QPRT | ||
| REACTOME: QPRT | ||
| Pathway Commons: QPRT | ||
| Context | iHOP: QPRT | |
| ligand binding site mutation search in PubMed: QPRT | ||
| UCL Cancer Institute: QPRT | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0034213 | quinolinate catabolic process | 3409840 | GO:0051259 | protein oligomerization | 17868694 |
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| Ligand binding site mutations for QPRT |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S268 | S268F | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for QPRT |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S268 | S268F | -0.77150599 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for QPRT from PDB |
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| Differential gene expression and gene-gene network for QPRT |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for QPRT |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for QPRT |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational|nutraceutical | DB00627 | Niacin | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of QPRT go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PHT | PHTHALIC ACID | 4kww | A | S268 | PHT | PHTHALIC ACID | 4kww | B | S268 | PHT | PHTHALIC ACID | 4kww | C | S268 | PHT | PHTHALIC ACID | 4kww | D | S268 | PHT | PHTHALIC ACID | 4kww | F | S268 |
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| Conservation information for LBS of QPRT |
| Multiple alignments for Q15274 in multiple species |
| LBS | AA sequence | # species | Species | E246 | PSVSVEASGGV | 2 | Mus musculus, Bos taurus | E246 | PSVAVEASGGI | 1 | Homo sapiens | E246 | ---ETEASGNV | 1 | Oryza sativa subsp. japonica | E246 | KHFLLECSGGL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E246 | PNVSVEASGGV | 1 | Rattus norvegicus | H160 | GGAASHRYDLG | 1 | Homo sapiens | H160 | GGGKNHRIGLF | 1 | Oryza sativa subsp. japonica | H160 | GGCDTHRYDLS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H160 | GGAACHRYDLG | 1 | Mus musculus | H160 | GGAECHRYDLG | 1 | Rattus norvegicus | H160 | GGAAAHRYDLG | 1 | Bos taurus | K171 | GLVMVKDNHVV | 2 | Homo sapiens, Rattus norvegicus | K171 | DMVMIKDNHIS | 1 | Oryza sativa subsp. japonica | K171 | SMVMLKDNHIW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K171 | GMVMVKDNHVV | 1 | Mus musculus | K171 | GLVMVKDNHVM | 1 | Bos taurus | M169 | LGGLVMVKDNH | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | M169 | LFDMVMIKDNH | 1 | Oryza sativa subsp. japonica | M169 | LSSMVMLKDNH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M169 | LGGMVMVKDNH | 1 | Mus musculus | R138 | HVAGTRKTTPG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R138 | CILETRKTAPG | 1 | Oryza sativa subsp. japonica | R138 | TIAGTRKTTPG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R161 | GAASHRYDLGG | 1 | Homo sapiens | R161 | GGKNHRIGLFD | 1 | Oryza sativa subsp. japonica | R161 | GCDTHRYDLSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R161 | GAACHRYDLGG | 1 | Mus musculus | R161 | GAECHRYDLGG | 1 | Rattus norvegicus | R161 | GAAAHRYDLGG | 1 | Bos taurus | S268 | HIDVISLGMLT | 2 | Mus musculus, Bos taurus | S268 | HIDVISMGMLT | 1 | Homo sapiens | S268 | GVTYISSGALT | 1 | Oryza sativa subsp. japonica | S268 | DIDIYSTSSIH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S268 | NIDVISLGMLT | 1 | Rattus norvegicus | T137 | GHVAGTRKTTP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T137 | -CILETRKTAP | 1 | Oryza sativa subsp. japonica | T137 | GTIAGTRKTTP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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