mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for QPRT
Gene summary
Basic gene Info.Gene symbolQPRT
Gene namequinolinate phosphoribosyltransferase
CytomapUCSC genome browser: 16p11.2
Type of geneprotein-coding
DescriptionQAPRTaseepididymis secretory sperm binding protein Li 90nnicotinate-nucleotide pyrophosphorylase (carboxylating)nicotinate-nucleotide pyrophosphorylase [carboxylating]
Modification date20141207
dbXrefs MIM : 606248
HPRD : 06950
ProteinUniProt: Q15274
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_QPRT
BioGPS: 23475
PathwayNCI Pathway Interaction Database: QPRT
Pathway Commons: QPRT
ContextiHOP: QPRT
ligand binding site mutation search in PubMed: QPRT
UCL Cancer Institute: QPRT
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0034213quinolinate catabolic process3409840
GO:0051259protein oligomerization17868694

Ligand binding site mutations for QPRT

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for QPRT
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for QPRT from PDB

Differential gene expression and gene-gene network for QPRT
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of QPRT and the right PPI network was created from samples without mutations in the LBS of QPRT. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for QPRT
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for QPRT
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigational|nutraceuticalDB00627NiacinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of QPRT go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of QPRT
Multiple alignments for Q15274 in multiple species
LBSAA sequence# speciesSpecies
E246PSVSVEASGGV2Mus musculus, Bos taurus
E246PSVAVEASGGI1Homo sapiens
E246---ETEASGNV1Oryza sativa subsp. japonica
E246KHFLLECSGGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E246PNVSVEASGGV1Rattus norvegicus
H160GGAASHRYDLG1Homo sapiens
H160GGGKNHRIGLF1Oryza sativa subsp. japonica
H160GGCDTHRYDLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H160GGAACHRYDLG1Mus musculus
H160GGAECHRYDLG1Rattus norvegicus
H160GGAAAHRYDLG1Bos taurus
K171GLVMVKDNHVV2Homo sapiens, Rattus norvegicus
K171DMVMIKDNHIS1Oryza sativa subsp. japonica
K171SMVMLKDNHIW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K171GMVMVKDNHVV1Mus musculus
K171GLVMVKDNHVM1Bos taurus
M169LGGLVMVKDNH3Homo sapiens, Rattus norvegicus, Bos taurus
M169LFDMVMIKDNH1Oryza sativa subsp. japonica
M169LSSMVMLKDNH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M169LGGMVMVKDNH1Mus musculus
R138HVAGTRKTTPG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R138CILETRKTAPG1Oryza sativa subsp. japonica
R138TIAGTRKTTPG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R161GAASHRYDLGG1Homo sapiens
R161GGKNHRIGLFD1Oryza sativa subsp. japonica
R161GCDTHRYDLSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R161GAACHRYDLGG1Mus musculus
R161GAECHRYDLGG1Rattus norvegicus
R161GAAAHRYDLGG1Bos taurus
S268HIDVISLGMLT2Mus musculus, Bos taurus
S268HIDVISMGMLT1Homo sapiens
S268GVTYISSGALT1Oryza sativa subsp. japonica
S268DIDIYSTSSIH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S268NIDVISLGMLT1Rattus norvegicus
T137GHVAGTRKTTP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T137-CILETRKTAP1Oryza sativa subsp. japonica
T137GTIAGTRKTTP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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