mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FOLR2
Gene summary
Basic gene Info.Gene symbolFOLR2
Gene namefolate receptor 2 (fetal)
SynonymsBETA-HFR|FBP|FBP/PL-1|FR-BETA|FR-P3
CytomapUCSC genome browser: 11q13.3-q13.5
Type of geneprotein-coding
RefGenesNM_000803.4,
NM_001113534.1,NM_001113535.1,NM_001113536.1,
Descriptionfolate receptor betafolate receptor, betafolate receptor, fetal/placentalfolate-binding protein, fetal/placentalplacental folate-binding protein
Modification date20141207
dbXrefs MIM : 136425
HGNC : HGNC
Ensembl : ENSG00000165457
HPRD : 00637
Vega : OTTHUMG00000150394
ProteinUniProt: P14207
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FOLR2
BioGPS: 2350
PathwayNCI Pathway Interaction Database: FOLR2
KEGG: FOLR2
REACTOME: FOLR2
Pathway Commons: FOLR2
ContextiHOP: FOLR2
ligand binding site mutation search in PubMed: FOLR2
UCL Cancer Institute: FOLR2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0015884folic acid transport4066659


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Ligand binding site mutations for FOLR2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y191V193ICOAD1
F78F78VSTAD1
W187L186ISTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for FOLR2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F78F78V-1.1756454
W187L186I-1.0563887
Y191V193I-0.84481746
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FOLR2 from PDB

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Differential gene expression and gene-gene network for FOLR2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FOLR2 and the right PPI network was created from samples without mutations in the LBS of FOLR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for FOLR2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027794Neural Tube Defects1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for FOLR2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceutical|vet_approvedDB00158Folic AcidSmall molecule
InvestigationalDB05168EC145Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FOLR2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MTXMETHOTREXATE4kn0AF78 W187
04JAMINOPTERINN-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)- L-GLUTAMIC ACID4kn1AF78 W187
LYALY2315144kn2AF78 W187
LYALY2315144kn2BF78 W187
LYALY2315144kn2CF78 W187 Y191
FOLFOLIC ACID4kmzAW187 Y191


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Conservation information for LBS of FOLR2
Multiple alignments for P14207 in multiple species
LBSAA sequence# speciesSpecies


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