mutLBSgeneDB |
Gene summary for FOLR2 |
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Basic gene Info. | Gene symbol | FOLR2 |
Gene name | folate receptor 2 (fetal) | |
Synonyms | BETA-HFR|FBP|FBP/PL-1|FR-BETA|FR-P3 | |
Cytomap | UCSC genome browser: 11q13.3-q13.5 | |
Type of gene | protein-coding | |
RefGenes | NM_000803.4, NM_001113534.1,NM_001113535.1,NM_001113536.1, | |
Description | folate receptor betafolate receptor, betafolate receptor, fetal/placentalfolate-binding protein, fetal/placentalplacental folate-binding protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 136425 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165457 | ||
HPRD : 00637 | ||
Vega : OTTHUMG00000150394 | ||
Protein | UniProt: P14207 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FOLR2 | |
BioGPS: 2350 | ||
Pathway | NCI Pathway Interaction Database: FOLR2 | |
KEGG: FOLR2 | ||
REACTOME: FOLR2 | ||
Pathway Commons: FOLR2 | ||
Context | iHOP: FOLR2 | |
ligand binding site mutation search in PubMed: FOLR2 | ||
UCL Cancer Institute: FOLR2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0015884 | folic acid transport | 4066659 |
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Ligand binding site mutations for FOLR2 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | Y191 | V193I | COAD | 1 | F78 | F78V | STAD | 1 | W187 | L186I | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FOLR2 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | F78 | F78V | -1.1756454 | W187 | L186I | -1.0563887 | Y191 | V193I | -0.84481746 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for FOLR2 |
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Phenotype information for FOLR2 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0027794 | Neural Tube Defects | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FOLR2 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|nutraceutical|vet_approved | DB00158 | Folic Acid | Small molecule | ![]() |
Investigational | DB05168 | EC145 | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MTX | METHOTREXATE | 4kn0 | A | F78 W187 | 04J | AMINOPTERIN | N-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)- L-GLUTAMIC ACID | 4kn1 | A | F78 W187 | LYA | LY231514 | 4kn2 | A | F78 W187 | LYA | LY231514 | 4kn2 | B | F78 W187 | LYA | LY231514 | 4kn2 | C | F78 W187 Y191 | FOL | FOLIC ACID | 4kmz | A | W187 Y191 |
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Conservation information for LBS of FOLR2 |
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LBS | AA sequence | # species | Species |
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