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mutLBSgeneDB |
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| Gene summary for MORC3 |
 Gene summary |
| Basic gene Info. | Gene symbol | MORC3 |
| Gene name | MORC family CW-type zinc finger 3 | |
| Synonyms | NXP2|ZCW5|ZCWCC3 | |
| Cytomap | UCSC genome browser: 21q22.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015358.2, | |
| Description | MORC family CW-type zinc finger protein 3nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3zinc finger, CW-type with coiled-coil domain 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610078 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000159256 | ||
| HPRD : 10316 | ||
| Vega : OTTHUMG00000086620 | ||
| Protein | UniProt: Q14149 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MORC3 | |
| BioGPS: 23515 | ||
| Pathway | NCI Pathway Interaction Database: MORC3 | |
| KEGG: MORC3 | ||
| REACTOME: MORC3 | ||
| Pathway Commons: MORC3 | ||
| Context | iHOP: MORC3 | |
| ligand binding site mutation search in PubMed: MORC3 | ||
| UCL Cancer Institute: MORC3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 17332504 | GO:0007569 | cell aging | 17332504 | GO:0018105 | peptidyl-serine phosphorylation | 17332504 | GO:0048147 | negative regulation of fibroblast proliferation | 17332504 | GO:0050821 | protein stabilization | 17332504 | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
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| Ligand binding site mutations for MORC3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P406 | R405H | COAD | 1 | C446 | R444G | GBM | 1 | E35 | V33A | UCEC | 1 | E35 | E35G | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MORC3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E35 | E35G | -1.3490911 | C446 | R444G | -1.3117388 | E35 | V33A | -1.1030595 | P406 | R405H | -0.83490382 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MORC3 from PDB |
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| Differential gene expression and gene-gene network for MORC3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MORC3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MORC3 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MORC3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4qq4 | A | C446 | ZN | ZINC(2+) | 4qq4 | B | C446 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG) | 4qq4 | A | P406 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG) | 4qq4 | B | P406 |
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| Conservation information for LBS of MORC3 |
| Multiple alignments for Q14149 in multiple species |
| LBS | AA sequence | # species | Species |
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