mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for SEC14L2

Gene summary

Basic gene Info.	Gene symbol	SEC14L2
	Gene name	SEC14-like 2 (S. cerevisiae)
	Synonyms	C22orf6\|SPF\|TAP\|TAP1
	Cytomap	UCSC genome browser: 22q12.2
	Type of gene	protein-coding
	RefGenes	NM_001204204.2, NM_001291932.1,NM_012429.4,NM_033382.2,
	Description	SEC14-like protein 2alpha-tocopherol-associated proteinsqualene transfer proteinsupernatant protein factortocopherol-associated protein
	Modification date	20141207
dbXrefs	MIM : 607558
	HGNC : HGNC
	Ensembl : ENSG00000100003
	HPRD : 06344
	Vega : OTTHUMG00000151024
Protein	UniProt: O76054 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SEC14L2
	BioGPS: 23541
Pathway	NCI Pathway Interaction Database: SEC14L2
	KEGG: SEC14L2
	REACTOME: SEC14L2
	Pathway Commons: SEC14L2
Context	iHOP: SEC14L2
	ligand binding site mutation search in PubMed: SEC14L2
	UCL Cancer Institute: SEC14L2
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for SEC14L2

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
L111	F113L	COAD	1
F178	F178Y	KIRC	1
K124	R126Q	STAD	1
L175	L175I	UCEC	1
I103	D101N	UCEC	1
L189	R188C	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for SEC14L2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
L189	R188C	-1.3331915
K124	R126Q	-1.2132335
L175	L175I	-0.84298465
I103	D101N	-0.83634292
L111	F113L	-0.60111072
F178	F178Y	-0.55630675

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SEC14L2 from PDB

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Differential gene expression and gene-gene network for SEC14L2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of SEC14L2 and the right PPI network was created from samples without mutations in the LBS of SEC14L2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for SEC14L2

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for SEC14L2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|nutraceutical\|vet_approved	DB00163	Vitamin E	Small molecule
Experimental	DB03796	Palmitic Acid	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SEC14L2 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
VTQ		D-ALPHA-TOCOPHERYLQUINONE	1olm	C	I103 K124 F178 L189
VTQ		D-ALPHA-TOCOPHERYLQUINONE	1olm	E	I103 L175 F178 L189
VTQ		D-ALPHA-TOCOPHERYLQUINONE	1olm	A	K124 L175 L189
2TX	2,3-OXIDOSQUALENE	(3S)-2,2-DIMETHYL-3-[(3E,7E,11E,15E)-3,7,12,16,20- PENTAMETHYLHENICOSA-3,7,11,15,19-PENTAEN-1-YL]OXIRANE	4omj	B	L111 K124 L175 L189
SQL	SQUALENE	(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2, 6,10,14,18,22-HEXAENE	4omk	A	L111 K124 L175 L189
SQL	SQUALENE	(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2, 6,10,14,18,22-HEXAENE	4omk	B	L111 K124 L175 L189
2TX	2,3-OXIDOSQUALENE	(3S)-2,2-DIMETHYL-3-[(3E,7E,11E,15E)-3,7,12,16,20- PENTAMETHYLHENICOSA-3,7,11,15,19-PENTAEN-1-YL]OXIRANE	4omj	A	L111 L175 L189

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Conservation information for LBS of SEC14L2

Multiple alignments for O76054 in multiple species

LBS	AA sequence	# species	Species
A108	IGPLDAKGLLF	2	Homo sapiens, Mus musculus
A108	IGPLDAKGLLL	1	Bos taurus
A108	LGNIDLKKLYQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A108	LGAVNLHEMNK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A108	LGSVNLTQMYK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A108	LGAVNLTEMYK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A167	HLWKPAVEAYG	3	Homo sapiens, Bos taurus, Mus musculus
A167	SIHS--VYSYI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A167	SAYS--VMSYV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A167	SAAQ--VLSYV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A167	AAAQ--VLSYV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A170	KPAVEAYGEFL	3	Homo sapiens, Bos taurus, Mus musculus
A170	Q--VLSYVREA	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A170	S--VYSYIRQA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A170	S--VMSYVREA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A201	KLFPVAYNLIK	2	Homo sapiens, Mus musculus
A201	FGFSTAFRLFK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A201	KLFPVAYNLVK	1	Bos taurus
A201	WGFSSAFNLIK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A201	FGFSAAFRLFK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C155	CTILDLKGISI	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C155	TIIYDCEGLGL	1	Homo sapiens
C155	TLIYDCEGLGL	1	Bos taurus
C155	TMIYDCEGLGL	1	Mus musculus
C155	CTIMDLKGVGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C155	CTIMDLKGISI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F174	EAYGEFLCMFE	2	Homo sapiens, Bos taurus
F174	LSYVREASNIG	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F174	EAYGEFLTMFE	1	Mus musculus
F174	YSYIRQASSIS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F174	MSYVREASYIS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F178	EFLCMFEEN-Y	2	Homo sapiens, Bos taurus
F178	REASNIGQNYY	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F178	EFLTMFEEN-Y	1	Mus musculus
F178	RQASSISQDYY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F178	REASYISQNYY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F198	KAPKLFPVAYN	3	Homo sapiens, Bos taurus, Mus musculus
F198	NAPFGFSTAFR	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F198	NAPWGFSSAFN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F198	NAPFGFSAAFR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H162	GLGLKHLWKPA	3	Homo sapiens, Bos taurus, Mus musculus
H162	GVGITSIHS--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H162	GISISSAYS--	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H162	GISISSAAQ--	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H162	GISISAAAQ--	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I103	VWYDIIGPLDA	2	Homo sapiens, Mus musculus
I103	IWYDIIGPLDA	1	Bos taurus
I103	VYVEQLGNIDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I103	VYFEELGAVNL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I103	VYIEELGSVNL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I103	VYIEELGAVNL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I151	VETSCTILDLK	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I151	VETITIIYDCE	1	Homo sapiens
I151	IEATTLIYDCE	1	Bos taurus
I151	IETITMIYDCE	1	Mus musculus
I151	IETSCTIMDLK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I151	VETSCTIMDLK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I205	VAYNLIKPFLS	2	Homo sapiens, Mus musculus
I205	TAFRLFKPFLD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I205	VAYNLVKPFLS	1	Bos taurus
I205	SAFNLIKGFLD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I205	AAFRLFKPFLD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I217	VTVSKIFILGS	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I217	DTRKKIMVLGA	1	Homo sapiens
I217	DTRKKIQVLGA	1	Bos taurus
I217	DTRRKIMVLGA	1	Mus musculus
I217	ATVKKIHILGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K124	RMLKNLVWEYE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K124	DLLRTKMRECE	1	Homo sapiens
K124	DLFKTKMRDCE	1	Bos taurus
K124	DLLRTKMRDCE	1	Mus musculus
K124	RMMQNLVYEYE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K124	RMLKNLIWEYE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L106	DIIGPLDAKGL	3	Homo sapiens, Bos taurus, Mus musculus
L106	EQLGNIDLKKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L106	EELGAVNLHEM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L106	EELGSVNLTQM	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L106	EELGAVNLTEM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L111	LDAKGLLFSAS	2	Homo sapiens, Mus musculus
L111	LDAKGLLLSAS	1	Bos taurus
L111	IDLKKLYQITT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L111	VNLHEMNKVTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L111	VNLTQMYKITT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L111	VNLTEMYKITT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L120	ASKQDLLRTKM	2	Homo sapiens, Mus musculus
L120	ASKQDLFKTKM	1	Bos taurus
L120	TTPERMMQNLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L120	TSEERMLKNLV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L120	TTQERMLKNLV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L120	TTQERMLKNLI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L121	SKQDLLRTKMR	2	Homo sapiens, Mus musculus
L121	SKQDLFKTKMR	1	Bos taurus
L121	TPERMMQNLVY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L121	SEERMLKNLVW	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L121	TQERMLKNLVW	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L121	TQERMLKNLIW	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L158	YDCEGLGLKHL	3	Homo sapiens, Bos taurus, Mus musculus
L158	MDLKGVGITSI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L158	MDLKGISISSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L158	LDLKGISISSA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L158	LDLKGISISAA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L163	LGLKHLWKPAV	3	Homo sapiens, Bos taurus, Mus musculus
L163	VGITSIHS--V	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L163	ISISSAYS--V	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L163	ISISSAAQ--V	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L163	ISISAAAQ--V	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L175	AYGEFLCMFEE	2	Homo sapiens, Bos taurus
L175	SYVREASNIGQ	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L175	AYGEFLTMFEE	1	Mus musculus
L175	SYIRQASSISQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L175	SYVREASYISQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L186	-YPETLKRLFV	2	Homo sapiens, Mus musculus
L186	-YPETLKRLFI	1	Bos taurus
L186	YYPERMGKFYV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L186	YYPERMGKFYI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L186	YYPERMGKFYL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L186	YYPERMGKFYM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L189	ETLKRLFVVKA	2	Homo sapiens, Mus musculus
L189	ETLKRLFIVKA	1	Bos taurus
L189	ERMGKFYVINA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L189	ERMGKFYIINA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L189	ERMGKFYLINA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L189	ERMGKFYMINA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L209	LFKPFLDPVTV	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L209	LIKPFLSEDTR	2	Homo sapiens, Mus musculus
L209	LVKPFLSEDTR	1	Bos taurus
L209	LIKGFLDEATV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L84	VIQQYLSGGMC	1	Homo sapiens
L84	VVQQYLSGGMC	1	Bos taurus
L84	VIQQYLSGGRC	1	Mus musculus
L84	AVSKYYPQFYH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L84	LIAKFYPQYYH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L84	LVAKYYPQYYH	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L84	LVAKFYPQYYH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T213	FLDPVTVSKIF	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T213	FLSEDTRKKIM	1	Homo sapiens
T213	FLSEDTRKKIQ	1	Bos taurus
T213	FLSEDTRRKIM	1	Mus musculus
T213	FLDEATVKKIH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V168	LWKPAVEAYGE	3	Homo sapiens, Bos taurus, Mus musculus
V168	AAQ--VLSYVR	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V168	IHS--VYSYIR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V168	AYS--VMSYVR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y153	TSCTILDLKGI	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y153	TITIIYDCEGL	1	Homo sapiens
Y153	ATTLIYDCEGL	1	Bos taurus
Y153	TITMIYDCEGL	1	Mus musculus
Y153	TSCTIMDLKGV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y153	TSCTIMDLKGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y171	PAVEAYGEFLC	2	Homo sapiens, Bos taurus
Y171	--VLSYVREAS	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y171	PAVEAYGEFLT	1	Mus musculus
Y171	--VYSYIRQAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y171	--VMSYVREAS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y202	LFPVAYNLIKP	2	Homo sapiens, Mus musculus
Y202	GFSTAFRLFKP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y202	LFPVAYNLVKP	1	Bos taurus
Y202	GFSSAFNLIKG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y202	GFSAAFRLFKP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)