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mutLBSgeneDB |
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| Gene summary for DNPEP |
 Gene summary |
| Basic gene Info. | Gene symbol | DNPEP |
| Gene name | aspartyl aminopeptidase | |
| Synonyms | ASPEP|DAP | |
| Cytomap | UCSC genome browser: 2q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012100.2, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611367 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123992 | ||
| HPRD : 09924 | ||
| Vega : OTTHUMG00000058919 | ||
| Protein | UniProt: Q9ULA0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DNPEP | |
| BioGPS: 23549 | ||
| Pathway | NCI Pathway Interaction Database: DNPEP | |
| KEGG: DNPEP | ||
| REACTOME: DNPEP | ||
| Pathway Commons: DNPEP | ||
| Context | iHOP: DNPEP | |
| ligand binding site mutation search in PubMed: DNPEP | ||
| UCL Cancer Institute: DNPEP | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for DNPEP |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y381 | V382M | COAD | 1 | T415 | V417F | KIRC | 1 | T415 | M416I | KIRC | 1 | E302 | V302L | LUAD | 1 | Y381 | K379R | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DNPEP |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DNPEP from PDB |
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| Differential gene expression and gene-gene network for DNPEP |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DNPEP |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DNPEP |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Nutraceutical | DB00142 | L-Glutamic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DNPEP go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4dyo | A | E302 | SD4 | L-ASPARAGINE | 4dyo | A | E302 Y381 T415 |
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| Conservation information for LBS of DNPEP |
| Multiple alignments for Q9ULA0 in multiple species |
| LBS | AA sequence | # species | Species | D264 | FAPRLDNLHSC | 3 | Homo sapiens, Mus musculus, Bos taurus | D264 | FSGRLDNLTSC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D264 | FSPRLDNLGMT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D264 | SGARLDNQVGT | 1 | Caenorhabditis elegans | D346 | FMISADMAHAV | 2 | Homo sapiens, Mus musculus | D346 | FFLSSDVAHAV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D346 | FLVSADMAHAM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D346 | MLISADQAHAT | 1 | Caenorhabditis elegans | D346 | YMISADMAHAV | 1 | Bos taurus | E301 | TLYDNEEVGSE | 2 | Homo sapiens, Mus musculus | E301 | ACFDHEEIGSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E301 | PSFDHEEIGSV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E301 | ACFDNEEVGSD | 1 | Caenorhabditis elegans | E301 | ALYDNEEVGSE | 1 | Bos taurus | E302 | LYDNEEVGSES | 3 | Homo sapiens, Mus musculus, Bos taurus | E302 | CFDHEEIGSSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E302 | SFDHEEIGSVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E302 | CFDNEEVGSDS | 1 | Caenorhabditis elegans | G414 | NDSPCGSTIGP | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G414 | NDSPCGTTIGP | 2 | Mus musculus, Bos taurus | G414 | NDTPCGTTIGP | 1 | Homo sapiens | G414 | NDSPCGSTVGP | 1 | Caenorhabditis elegans | H349 | SADMAHAVHPN | 3 | Homo sapiens, Mus musculus, Bos taurus | H349 | SSDVAHAVHPN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H349 | SADMAHAMHPN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H349 | SADQAHATHPN | 1 | Caenorhabditis elegans | H440 | PQLAMHSIRET | 2 | Mus musculus, Bos taurus | H440 | PQLAMHSIREM | 1 | Homo sapiens | H440 | PVLSMHSIRET | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H440 | PMLSMHSCREM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H440 | PQLAMHSIREF | 1 | Caenorhabditis elegans | H94 | SLIGAHTDSPC | 3 | Homo sapiens, Mus musculus, Bos taurus | H94 | AITGAHTDSPA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H94 | SIIATHTDSPT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H94 | SIVVGHTDSPC | 1 | Caenorhabditis elegans | K374 | KGPVIKVNSKQ | 3 | Homo sapiens, Mus musculus, Bos taurus | K374 | GGPVIKINANQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K374 | KGTVIKVNANQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K374 | GGVVVKVNVNQ | 1 | Caenorhabditis elegans | M347 | MISADMAHAVH | 3 | Homo sapiens, Mus musculus, Bos taurus | M347 | FLSSDVAHAVH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M347 | LVSADMAHAMH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M347 | LISADQAHATH | 1 | Caenorhabditis elegans | M439 | SPQLAMHSIRE | 3 | Homo sapiens, Mus musculus, Bos taurus | M439 | NPVLSMHSIRE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M439 | NPMLSMHSCRE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M439 | CPQLAMHSIRE | 1 | Caenorhabditis elegans | T415 | DSPCGTTIGPI | 2 | Mus musculus, Bos taurus | T415 | DTPCGTTIGPI | 1 | Homo sapiens | T415 | DSPCGSTIGPI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T415 | DSPCGSTIGPK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T415 | DSPCGSTVGPI | 1 | Caenorhabditis elegans | Y381 | NSKQRYASNAV | 3 | Homo sapiens, Mus musculus, Bos taurus | Y381 | NANQRYMTNSP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y381 | NANQRYTTNSA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y381 | NVNQRYATTST | 1 | Caenorhabditis elegans |
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