mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZNF346
Gene summary
Basic gene Info.Gene symbolZNF346
Gene namezinc finger protein 346
CytomapUCSC genome browser: 5q35.2
Type of geneprotein-coding
Descriptiondouble-stranded RNA-binding zinc finger protein JAZjust another zinc finger protein
Modification date20141207
dbXrefs MIM : 605308
Ensembl : ENSG00000113761
HPRD : 05606
Vega : OTTHUMG00000130848
ProteinUniProt: Q9UL40
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZNF346
BioGPS: 23567
PathwayNCI Pathway Interaction Database: ZNF346
Pathway Commons: ZNF346
ContextiHOP: ZNF346
ligand binding site mutation search in PubMed: ZNF346
UCL Cancer Institute: ZNF346
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ZNF346

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ZNF346
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZNF346 from PDB

Differential gene expression and gene-gene network for ZNF346
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZNF346 and the right PPI network was created from samples without mutations in the LBS of ZNF346. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ZNF346
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ZNF346
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZNF346 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ZNF346
Multiple alignments for Q9UL40 in multiple species
LBSAA sequence# speciesSpecies
C187DPDKFCSLCHA1Homo sapiens
C187DPNRFCSICQA1Danio rerio
C187DPTKFCKLCHA1Xenopus tropicalis
C187DPDKFCSLCHS1Mus musculus
C190KFCSLCHATFN1Homo sapiens
C190RFCSICQASFN1Danio rerio
C190KFCKLCHATFN1Xenopus tropicalis
C190KFCSLCHSTFN1Mus musculus
D196HATFNDPVMAQ1Homo sapiens
D196QASFNNPLMAQ1Danio rerio
D196HATFNNPLMAE1Xenopus tropicalis
D196HSTFNDPAMAQ1Mus musculus
G206QQHYVGKKHRK1Homo sapiens
G206QQHYSGKKHKK1Danio rerio
G206EQHYAGKKHKK1Xenopus tropicalis
G206QQHYMGKRHRK1Mus musculus
H203VMAQQHYVGKK1Homo sapiens
H203LMAQQHYSGKK1Danio rerio
H203LMAEQHYAGKK1Xenopus tropicalis
H203AMAQQHYMGKR1Mus musculus
H209YVGKKHRKQET1Homo sapiens
H209YSGKKHKKHMN1Danio rerio
H209YAGKKHKKQET1Xenopus tropicalis
H209YMGKRHRKQET1Mus musculus
K207QHYVGKKHRKQ1Homo sapiens
K207QHYSGKKHKKH1Danio rerio
K207QHYAGKKHKKQ1Xenopus tropicalis
K207QHYMGKRHRKQ1Mus musculus
K208HYVGKKHRKQE1Homo sapiens
K208HYSGKKHKKHM1Danio rerio
K208HYAGKKHKKQE1Xenopus tropicalis
K208HYMGKRHRKQE1Mus musculus
K211GKKHRKQETKL1Homo sapiens
K211GKKHKKHMNKQ1Danio rerio
K211GKKHKKQETKT1Xenopus tropicalis
K211GKRHRKQETKL1Mus musculus
K215RKQETKLKLMA2Homo sapiens, Mus musculus
K215KKHMNKQKLME1Danio rerio
K215KKQETKTQLMT1Xenopus tropicalis
M199FNDPVMAQQHY1Homo sapiens
M199FNNPLMAQQHY1Danio rerio
M199FNNPLMAEQHY1Xenopus tropicalis
M199FNDPAMAQQHY1Mus musculus
P197ATFNDPVMAQQ1Homo sapiens
P197ASFNNPLMAQQ1Danio rerio
P197ATFNNPLMAEQ1Xenopus tropicalis
P197STFNDPAMAQQ1Mus musculus
Q202PVMAQQHYVGK1Homo sapiens
Q202PLMAQQHYSGK1Danio rerio
Q202PLMAEQHYAGK1Xenopus tropicalis
Q202PAMAQQHYMGK1Mus musculus
Q212KKHRKQETKLK1Homo sapiens
Q212KKHKKHMNKQK1Danio rerio
Q212KKHKKQETKTQ1Xenopus tropicalis
Q212KRHRKQETKLK1Mus musculus
V198TFNDPVMAQQH1Homo sapiens
V198SFNNPLMAQQH1Danio rerio
V198TFNNPLMAEQH1Xenopus tropicalis
V198TFNDPAMAQQH1Mus musculus

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