mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DAPK2
Gene summary
Basic gene Info.Gene symbolDAPK2
Gene namedeath-associated protein kinase 2
CytomapUCSC genome browser: 15q22.31
Type of geneprotein-coding
DescriptionDAP kinase 2DAP-kinase-related protein 1 beta isoform
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000035664
HPRD : 09905
Vega : OTTHUMG00000132947
ProteinUniProt: Q9UIK4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DAPK2
BioGPS: 23604
PathwayNCI Pathway Interaction Database: DAPK2
Pathway Commons: DAPK2
ContextiHOP: DAPK2
ligand binding site mutation search in PubMed: DAPK2
UCL Cancer Institute: DAPK2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006468protein phosphorylation10376525
GO:0035556intracellular signal transduction10376525

Ligand binding site mutations for DAPK2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DAPK2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DAPK2 from PDB

Differential gene expression and gene-gene network for DAPK2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DAPK2 and the right PPI network was created from samples without mutations in the LBS of DAPK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DAPK2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DAPK2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DAPK2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of DAPK2
Multiple alignments for Q9UIK4 in multiple species
LBSAA sequence# speciesSpecies
A50TGLEYAAKFIK2Homo sapiens, Mus musculus
A50NGTEFACKTLK1Arabidopsis thaliana
E104VVLILELVSGG2Homo sapiens, Mus musculus
E104FHLVMELCSGG1Arabidopsis thaliana
G30IGEELGSGQFA2Homo sapiens, Mus musculus
G30FGRNIGKGKFG1Arabidopsis thaliana
I170PHIKLIDFGLA2Homo sapiens, Mus musculus
I170-KIQLADFGLA1Arabidopsis thaliana
I87-HHNVITLHDV1Homo sapiens
I87GHPRVVTLHAV1Arabidopsis thaliana
I87-HPNIITLHDV1Mus musculus
L105VLILELVSGGE2Homo sapiens, Mus musculus
L105HLVMELCSGGR1Arabidopsis thaliana
L29DIGEELGSGQF2Homo sapiens, Mus musculus
L29VFGRNIGKGKF1Arabidopsis thaliana
M156KPENIMLLDKN2Homo sapiens, Mus musculus
M156KPENILLTAAG1Arabidopsis thaliana
S31GEELGSGQFAI2Homo sapiens, Mus musculus
S31GRNIGKGKFGS1Arabidopsis thaliana
V106LILELVSGGEL2Homo sapiens, Mus musculus
V106LVMELCSGGRL1Arabidopsis thaliana
V37GQFAIVKKCRE2Homo sapiens, Mus musculus
V37GKFGSVRICKS1Arabidopsis thaliana

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