mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for BACE1

Gene summary

Basic gene Info.	Gene symbol	BACE1
	Gene name	beta-site APP-cleaving enzyme 1
	Synonyms	ASP2\|BACE\|HSPC104
	Cytomap	UCSC genome browser: 11q23.2-q23.3
	Type of gene	protein-coding
	RefGenes	NM_001207048.1, NM_001207049.1,NM_012104.4,NM_138971.3,NM_138972.3, NM_138973.3,
	Description	APP beta-secretaseasp 2aspartyl protease 2beta-secretase 1beta-secretase 1 precursor variant 1beta-site APP cleaving enzyme 1beta-site amyloid beta A4 precursor protein-cleaving enzymememapsin-2membrane-associated aspartic protease 2transmembrane
	Modification date	20141222
dbXrefs	MIM : 604252
	HGNC : HGNC
	Ensembl : ENSG00000186318
	HPRD : 07255
	Vega : OTTHUMG00000160636
Protein	UniProt: P56817 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_BACE1
	BioGPS: 23621
Pathway	NCI Pathway Interaction Database: BACE1
	KEGG: BACE1
	REACTOME: BACE1
	Pathway Commons: BACE1
Context	iHOP: BACE1
	ligand binding site mutation search in PubMed: BACE1
	UCL Cancer Institute: BACE1
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006508	proteolysis	10531052
GO:0006509	membrane protein ectodomain proteolysis	18353773
GO:0050435	beta-amyloid metabolic process	15080893

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Ligand binding site mutations for BACE1

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
Y281,Y283	D282N	BRCA	1
P131	R131L	KIRC	1
P131	R131L	LUAD	1
H110	I111M	LUAD	1
N294	A294G	OV	1
C216	F216L	STAD	1
P131	R131Q	UCEC	1
N339	A338T	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for BACE1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS

AAchange of nsSNV

Relative stability change

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for BACE1 from PDB

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Differential gene expression and gene-gene network for BACE1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of BACE1 and the right PPI network was created from samples without mutations in the LBS of BACE1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for BACE1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0002395	Alzheimer Disease	71	AlteredExpression, Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for BACE1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB02378	MMI-175	Small molecule
Investigational	DB06073	CTS-21166	Small molecule
Experimental	DB06930	N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide	Small molecule
Experimental	DB07019	N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE	Small molecule
Experimental	DB07089	N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide	Small molecule
Experimental	DB07110	4-(4-FLUOROBENZYL)PIPERIDINE	Small molecule
Experimental	DB07175	N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide	Small molecule
Experimental	DB07206	6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE	Small molecule
Experimental	DB07245	6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE	Small molecule
Experimental	DB07281	N~3~-BENZYLPYRIDINE-2,3-DIAMINE	Small molecule
Experimental	DB07284	N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE	Small molecule
Experimental	DB07303	N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE	Small molecule
Experimental	DB07345	4-(2-aminoethyl)-2-cyclohexylphenol	Small molecule
Experimental	DB07346	4-(2-aminoethyl)-2-ethylphenol	Small molecule
Experimental	DB07415	4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine	Small molecule
Experimental	DB07519	(6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one	Small molecule
Experimental	DB07535	2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one	Small molecule
Experimental	DB07573	(2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol	Small molecule
Experimental	DB07734	N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide	Small molecule
Experimental	DB07735	N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide	Small molecule
Experimental	DB07736	(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide	Small molecule
Experimental	DB07737	(2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide	Small molecule
Experimental	DB07738	N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide	Small molecule
Experimental	DB07874	(6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one	Small molecule
Experimental	DB07993	N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE	Small molecule
Experimental	DB07994	N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE	Small molecule
Experimental	DB08749	3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE	Small molecule
Investigational	DB08929	MK-8931	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of BACE1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
ZN		ZINC(2+)	4i10	A	H110
VG3		N-[(1S,2R)-1-BENZYL-3-{[(1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL]AMINO}-2-HYDROXYPROPYL]-3-(PENTYLSULFONYL)BENZAMIDE	2viy	A	N294
VG4		N-[(1S,2R)-1-BENZYL-3-{[(1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL]AMINO}-2-HYDROXYPROPYL]-3-(2-OXO-2,3-DIHYDRO-1H-PYRROL-1-YL)-5-PROPOXYBENZAMIDE	2viz	A	N294
VG5		N-[(1S,2R)-1-BENZYL-3-{[(1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL]AMINO}-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE	2vj6	A	N294
VG7		N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE	2vj9	A	N294
ZY4		N-[(1S)-1-BENZYL-2,2-DIHYDROXY-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL]-6-ETHYL-1-METHYL-1,3,4,6-TETRAHYDRO[1,2]THIAZEPINO[5,4,3-CD]INDOLE-8-CARBOXAMIDE 2,2-DIOXIDE	2wf4	A	N294
0ZA		3-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4- DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-1,2,4- OXADIAZOL-5(2H)-ONE	4hzt	A	N294
1BB		2-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4- DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-4-OXO-1, 4-DIHYDROPYRIMIDINE-5-CARBONITRILE	4i0z	A	N294
1BS		2-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4- DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}PYRIDO[4, 3-D]PYRIMIDIN-4(1H)-ONE	4i10	A	N294
1BC		2-{(1S)-1-{[(1Z)-6-CHLORO-3,3-DIMETHYL-3,4- DIHYDROISOQUINOLIN-1(2H)-YLIDENE]AMINO}-2-[2-PROPYL-4- (1H-PYRAZOL-4-YL)THIOPHEN-3-YL]ETHYL}PYRIMIDIN-4(5H)- ONE	4i12	A	N294
III		Peptide ligand (GLU,ILE,TIH,LHE)	4trw	A	N294
III		Peptide ligand (GLU,ILE,TIH,TVA)	4trz	A	N294
III		Peptide ligand (GLU,ILE,TIH,TVA)	4trz	B	N294
III		Peptide ligand (GLU,ILE,TIH,TVA)	4trz	C	N294
C44		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(1S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLAMINO]PROPYL}-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE	2vij	A	N339
CS5		N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	2qk5	A	P131
CS5		N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	2qk5	B	P131
CS7		N'-[(1S,2R)-2-[(2R,4R)-4-(BENZYLOXY)PYRROLIDIN-2-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	2qmd	A	P131
CS7		N'-[(1S,2R)-2-[(2R,4R)-4-(BENZYLOXY)PYRROLIDIN-2-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	2qmd	B	P131
CS9		N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	2qmf	A	P131
CS9		N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	2qmf	B	P131
SC6		N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE	2qmg	A	P131
SC6		N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE	2qmg	B	P131
318		N'-[(1S,2S)-2-[(4S)-1-BENZYL-5-OXOIMIDAZOLIDIN-4-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLBENZENE-1,3-DICARBOXAMIDE	3cid	A	P131
318		N'-[(1S,2S)-2-[(4S)-1-BENZYL-5-OXOIMIDAZOLIDIN-4-YL]-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYETHYL]-5-METHYL-N,N-DIPROPYLBENZENE-1,3-DICARBOXAMIDE	3cid	B	P131
1LI		N-[(1S,2R)-3-{[1-(3-TERT-BUTYLPHENYL)CYCLOHEXYL]AMINO}-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYPROPYL]ACETAMIDE	3ivh	A	P131
2LI		N-[(1S,2R)-3-{[(5S)-5-(3-TERT-BUTYLPHENYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-5-YL]AMINO}-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYPROPYL]ACETAMIDE	3ivi	A	P131
2LI		N-[(1S,2R)-3-{[(5S)-5-(3-TERT-BUTYLPHENYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-5-YL]AMINO}-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYPROPYL]ACETAMIDE	3ivi	B	P131
2LI		N-[(1S,2R)-3-{[(5S)-5-(3-TERT-BUTYLPHENYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-5-YL]AMINO}-1-(3,5-DIFLUOROBENZYL)-2-HYDROXYPROPYL]ACETAMIDE	3ivi	C	P131
CS5		N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	3l58	A	P131
CS5		N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE	3l58	B	P131
Z76		N-[(1S,2S)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-{(2R)-4-[(3-METHYLPHENYL)SULFONYL]PIPERAZIN-2-YL}ETHYL]-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE	3lpk	A	P131
842		N-[(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-({1-[3-(1H-PYRAZOL-1-YL)PHENYL]CYCLOHEXYL}AMINO)PROPYL]ACETAMIDE	4i0j	A	P131
VG0		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(1,1,5-TRIMETHYLHEXYL)AMINO]PROPYL}-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE	2vie	A	P131 N294
C44		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(1S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLAMINO]PROPYL}-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE	2vij	A	P131 N294
VG6		N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE	2vj7	A	P131 N294
CM8		N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE	2vnm	A	P131 N294
CM7		N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE	2vnn	A	P131 N294
ZYE		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-1-ETHYL-4-(2-OXOPYRROLIDIN-1-YL)-1H-INDOLE-6-CARBOXAMIDE	2wez	A	P131 N294
ZY0		N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE	2wf0	A	P131 N294
ZY1		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE	2wf1	A	P131 N294
ZY2		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-8-ETHYL-1-METHYL-3,4,7,8-TETRAHYDRO-1H,6H-[1,2,5]THIADIAZEPINO[5,4,3-DE]QUINOXALINE-10-CARBOXAMIDE 2,2-DIOXIDE	2wf2	A	P131 N294
ZY3		N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-6-(ETHYLAMINO)-1-METHYL-1,3,4,5-TETRAHYDRO-2,1-BENZOTHIAZEPINE-8-CARBOXAMIDE 2,2-DIOXIDE	2wf3	A	P131 N294
XFI		N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)BENZAMIDE	2xfi	A	P131 N294
VG5		N-[(1S,2R)-1-BENZYL-3-{[(1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL]AMINO}-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE	2xfj	A	P131 N294
AA9		N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1--METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-((METHYLSULFONYL)(PHENYL)AMINO)BENZAMIDE	2xfk	A	P131 N294
III		Peptide ligand (GLU,ILE,TIH,LHE)	4trw	B	P131 N294
III		Peptide ligand (GLU,ILE,TIH,LHE)	4trw	C	P131 N294

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Conservation information for LBS of BACE1

Multiple alignments for P56817 in multiple species

LBS	AA sequence	# species	Species
A100	GSSNFAVGAAP	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A218	LQLCGAGFPLN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A396	GTVMGAVIMEG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C216	FSLQLCGAGFP	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D167	AITESDKFFIN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D192	IARPDDSLEPF	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D284	KEYNYDKSIVD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D289	DKSIVDSGTTN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D93	LNILVDTGSSN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E138	TQGKWEGELGT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E165	IAAITESDKFF	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E186	GLAYAEIARPD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E280	KMDCKEYNYDK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E326	GFWLGEQLVCW	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E400	GAVIMEGFYVV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E78	QGYYVEMTVGS	3	Homo sapiens, Mus musculus, Rattus norvegicus
E78	QGYYVEMTLGS	1	Bos taurus
F169	TESDKFFINGS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F170	ESDKFFINGSN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F426	HVHDEFRTAAV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G135	VPYTQGKWEGE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G217	SLQLCGAGFPL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G232	ALASVGGSMII	3	Mus musculus, Rattus norvegicus, Bos taurus
G232	VLASVGGSMII	1	Homo sapiens
G271	RVEINGQDLKM	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G291	SIVDSGTTNLR	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G69	VDNLRGKSGQG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G72	LRGKSGQGYYV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G74	GKSGQGYYVEM	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G95	ILVDTGSSNFA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H110	PHPFLHRYYQR	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H150	LVSIPHGPNVT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H20	GMLPAQGTHLG	2	Mus musculus, Rattus norvegicus
H20	GVLPAHGTQHG	1	Homo sapiens
H20	GVLPAHGSQPG	1	Bos taurus
I171	SDKFFINGSNW	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I179	SNWEGILGLAY	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I187	LAYAEIARPDD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I287	NYDKSIVDSGT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K136	PYTQGKWEGEL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K168	ITESDKFFING	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K279	LKMDCKEYNYD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K285	EYNYDKSIVDS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K382	QDDCYKFAISQ	2	Homo sapiens, Bos taurus
K382	QDDCYKFAVSQ	2	Mus musculus, Rattus norvegicus
L145	ELGTDLVSIPH	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L222	GAGFPLNQTEA	2	Mus musculus, Rattus norvegicus
L222	GAGFPLNQSEV	1	Homo sapiens
L222	GAGFPLNQSEA	1	Bos taurus
L328	WLGEQLVCWQA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L91	QTLNILVDTGS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N172	DKFFINGSNWE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N175	FINGSNWEGIL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N270	VRVEINGQDLK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N294	DSGTTNLRLPK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N339	GTTPWNIFPVI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N98	DTGSSNFAVGA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P131	KGVYVPYTQGK	3	Homo sapiens, Mus musculus, Bos taurus
P131	KSVYVPYTQGK	1	Rattus norvegicus
Q134	YVPYTQGKWEG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q204	DSLVKQTHVPN	2	Homo sapiens, Bos taurus
Q204	DSLVKQTHIPN	2	Mus musculus, Rattus norvegicus
Q73	RGKSGQGYYVE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R189	YAEIARPDDSL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R296	GTTNLRLPKKV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R368	PQQYLRPVEDV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R427	VHDEFRTAAVE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S230	TEALASVGGSM	2	Mus musculus, Rattus norvegicus
S230	SEVLASVGGSM	1	Homo sapiens
S230	SEALASVGGSM	1	Bos taurus
S290	KSIVDSGTTNL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S386	YKFAISQSSTG	2	Homo sapiens, Bos taurus
S386	YKFAVSQSSTG	2	Mus musculus, Rattus norvegicus
S388	FAISQSSTGTV	2	Homo sapiens, Bos taurus
S388	FAVSQSSTGTV	2	Mus musculus, Rattus norvegicus
S389	AISQSSTGTVM	2	Homo sapiens, Bos taurus
S389	AVSQSSTGTVM	2	Mus musculus, Rattus norvegicus
S71	NLRGKSGQGYY	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S83	EMTVGSPPQTL	3	Homo sapiens, Mus musculus, Rattus norvegicus
S83	EMTLGSPPQTL	1	Bos taurus
S96	LVDTGSSNFAV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T133	VYVPYTQGKWE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T155	HGPNVTVRANI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T292	IVDSGTTNLRL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T293	VDSGTTNLRLP	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T390	ISQSSTGTVMG	2	Homo sapiens, Bos taurus
T390	VSQSSTGTVMG	2	Mus musculus, Rattus norvegicus
T428	HDEFRTAAVEG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V130	RKGVYVPYTQG	3	Homo sapiens, Mus musculus, Bos taurus
V130	RKSVYVPYTQG	1	Rattus norvegicus
V231	EALASVGGSMI	3	Mus musculus, Rattus norvegicus, Bos taurus
V231	EVLASVGGSMI	1	Homo sapiens
V343	WNIFPVISLYL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V370	QYLRPVEDVAT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V373	RPVEDVATSQD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V393	SSTGTVMGAVI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V92	TLNILVDTGSS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W137	YTQGKWEGELG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W176	INGSNWEGILG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W258	PIRREWYYEVI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y129	LRKGVYVPYTQ	3	Homo sapiens, Mus musculus, Bos taurus
Y129	LRKSVYVPYTQ	1	Rattus norvegicus
Y132	GVYVPYTQGKW	3	Homo sapiens, Mus musculus, Bos taurus
Y132	SVYVPYTQGKW	1	Rattus norvegicus
Y259	IRREWYYEVII	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y281	MDCKEYNYDKS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y283	CKEYNYDKSIV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y75	KSGQGYYVEMT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus