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mutLBSgeneDB |
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| Gene summary for PLA2G15 |
 Gene summary |
| Basic gene Info. | Gene symbol | PLA2G15 |
| Gene name | phospholipase A2, group XV | |
| Synonyms | ACS|GXVPLA2|LLPL|LPLA2|LYPLA3 | |
| Cytomap | UCSC genome browser: 16q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012320.3, | |
| Description | 1-O-acylceramide synthaseLCAT-like lysophospholipasegroup XV phospholipase A2lysophospholipase 3 (lysosomal phospholipase A2)lysosomal phospholipase A2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609362 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000103066 | ||
| HPRD : 07128 | ||
| Vega : OTTHUMG00000137554 | ||
| Protein | UniProt: Q8NCC3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLA2G15 | |
| BioGPS: 23659 | ||
| Pathway | NCI Pathway Interaction Database: PLA2G15 | |
| KEGG: PLA2G15 | ||
| REACTOME: PLA2G15 | ||
| Pathway Commons: PLA2G15 | ||
| Context | iHOP: PLA2G15 | |
| ligand binding site mutation search in PubMed: PLA2G15 | ||
| UCL Cancer Institute: PLA2G15 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PLA2G15 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R247 | N245S | BRCA | 1 | T362 | T362A | COAD | 1 | Y137 | S136F | HNSC | 1 | W163 | R165Q | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PLA2G15 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T362 | T362A | -1.1125656 | W163 | R165Q | -0.78366513 | Y137 | S136F | -0.68717987 | R247 | N245S | -0.6702182 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PLA2G15 from PDB |
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| Differential gene expression and gene-gene network for PLA2G15 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PLA2G15 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PLA2G15 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PLA2G15 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PLA2G15 |
| Multiple alignments for Q8NCC3 in multiple species |
| LBS | AA sequence | # species | Species | A263 | EQQRSAVSTSW | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | A263 | RHQRTSESNQW | 1 | Arabidopsis thaliana | A263 | AQQRSAVSTTW | 1 | Bos taurus | D46 | VLVPGDLGNQL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | D46 | ILVPGNGGNQL | 1 | Arabidopsis thaliana | D46 | VLVPGDMGNQL | 1 | Bos taurus | G45 | VVLVPGDLGNQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | G45 | LILVPGNGGNQ | 1 | Arabidopsis thaliana | G45 | VVLVPGDMGNQ | 1 | Bos taurus | H197 | VVLVAHSMGNM | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Canis lupus familiaris | H197 | VILLSHSLGGL | 1 | Arabidopsis thaliana | H197 | VVLVAHSMGNV | 1 | Mus musculus | H392 | LPGSEHI--EM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | H392 | ILKDEIALKEI | 1 | Arabidopsis thaliana | H392 | LPGNEHI--AM | 1 | Bos taurus | I248 | GDNNRIPVIGP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I248 | GNTLGVPLVNP | 1 | Arabidopsis thaliana | I248 | GDNNRIPVIRS | 1 | Bos taurus | I248 | GDNNRIPVIRP | 1 | Canis lupus familiaris | I393 | PGSEHI--EML | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | I393 | LKDEIALKEIM | 1 | Arabidopsis thaliana | I393 | PGNEHI--AML | 1 | Bos taurus | K235 | WGGVAKTLRVL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | K235 | WGGTISQMKTF | 1 | Arabidopsis thaliana | K235 | WGGVPKTLRVL | 1 | Bos taurus | L127 | FSLEFLDPSKS | 2 | Homo sapiens, Canis lupus familiaris | L127 | KSLLYLDPRLR | 1 | Arabidopsis thaliana | L127 | FSMEFLDPSKS | 1 | Bos taurus | L127 | FSMEFLDPSKR | 1 | Mus musculus | L127 | FSLEFLDPSKR | 1 | Rattus norvegicus | L269 | VSTSWLLPYNY | 2 | Homo sapiens, Canis lupus familiaris | L269 | VSTSWLLPYNH | 2 | Mus musculus, Rattus norvegicus | L269 | ESNQWLLPSTK | 1 | Arabidopsis thaliana | L269 | VSTTWLLPYSY | 1 | Bos taurus | L47 | LVPGDLGNQLE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | L47 | LVPGNGGNQLE | 1 | Arabidopsis thaliana | L47 | LVPGDMGNQLE | 1 | Bos taurus | L79 | TLWLNLELLLP | 4 | Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris | L79 | TIWLNLELLLP | 1 | Homo sapiens | L79 | RLWFDAAVLLS | 1 | Arabidopsis thaliana | L82 | LNLELLLPVII | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris | L82 | FDAAVLLSPFT | 1 | Arabidopsis thaliana | M199 | LVAHSMGNMYT | 2 | Homo sapiens, Canis lupus familiaris | M199 | LVAHSMGNMYM | 2 | Bos taurus, Rattus norvegicus | M199 | LLSHSLGGLFV | 1 | Arabidopsis thaliana | M199 | LVAHSMGNVYM | 1 | Mus musculus | P229 | VSLGAPWGGVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P229 | VALAAPWGGTI | 1 | Arabidopsis thaliana | P229 | VALGPPWGGVP | 1 | Bos taurus | P229 | VALGAPWGGVA | 1 | Canis lupus familiaris | Q259 | LKIREQQRSAV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | Q259 | LLVRRHQRTSE | 1 | Arabidopsis thaliana | Q259 | LKIRAQQRSAV | 1 | Bos taurus | Q260 | KIREQQRSAVS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | Q260 | LVRRHQRTSES | 1 | Arabidopsis thaliana | Q260 | KIRAQQRSAVS | 1 | Bos taurus | R247 | SGDNNRIPVIG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R247 | SGDNNRIPVIR | 2 | Bos taurus, Canis lupus familiaris | R247 | SGNTLGVPLVN | 1 | Arabidopsis thaliana | S198 | VLVAHSMGNMY | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Canis lupus familiaris | S198 | ILLSHSLGGLF | 1 | Arabidopsis thaliana | S198 | VLVAHSMGNVY | 1 | Mus musculus | T236 | GGVAKTLRVLA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | T236 | GGTISQMKTFA | 1 | Arabidopsis thaliana | T236 | GGVPKTLRVLA | 1 | Bos taurus | T266 | RSAVSTSWLLP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | T266 | RTSESNQWLLP | 1 | Arabidopsis thaliana | T266 | RSAVSTTWLLP | 1 | Bos taurus | T362 | GDGDGTVNLES | 2 | Mus musculus, Rattus norvegicus | T362 | GDGDGTVNLKS | 1 | Homo sapiens | T362 | GDGDGTVNLAS | 1 | Arabidopsis thaliana | T362 | GTGDGTVNLQS | 1 | Bos taurus | T362 | GDGDGTVNLQS | 1 | Canis lupus familiaris | V134 | PSKSSVGSYFH | 2 | Homo sapiens, Canis lupus familiaris | V134 | PSKRNVGSYFY | 2 | Mus musculus, Rattus norvegicus | V134 | PRLRDATSYME | 1 | Arabidopsis thaliana | V134 | PSKSSVGSYLH | 1 | Bos taurus | V233 | APWGGVAKTLR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris | V233 | APWGGTISQMK | 1 | Arabidopsis thaliana | V233 | PPWGGVPKTLR | 1 | Bos taurus | W163 | GAPYDWRRAPN | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris | W163 | GAPYDFRYGLA | 1 | Arabidopsis thaliana | W76 | SYFTLWLNLEL | 3 | Mus musculus, Rattus norvegicus, Canis lupus familiaris | W76 | SYFTIWLNLEL | 1 | Homo sapiens | W76 | GWFRLWFDAAV | 1 | Arabidopsis thaliana | W76 | HYFTLWLNLEL | 1 | Bos taurus | Y137 | SSVGSYFHTMV | 2 | Homo sapiens, Canis lupus familiaris | Y137 | RNVGSYFYTMV | 2 | Mus musculus, Rattus norvegicus | Y137 | RDATSYMEHLV | 1 | Arabidopsis thaliana | Y137 | SSVGSYLHTMV | 1 | Bos taurus |
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