mutLBSgeneDB |
Gene summary for ZKSCAN5 |
Gene summary |
Basic gene Info. | Gene symbol | ZKSCAN5 |
Gene name | zinc finger with KRAB and SCAN domains 5 | |
Synonyms | ZFP95|ZNF914|ZSCAN37 | |
Cytomap | UCSC genome browser: 7q22 | |
Type of gene | protein-coding | |
RefGenes | NM_014569.3, NM_145102.2, | |
Description | zfp-95zinc finger protein 95 homologzinc finger protein homologous to Zfp95 in mousezinc finger protein with KRAB and SCAN domains 5 | |
Modification date | 20141211 | |
dbXrefs | MIM : 611272 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196652 | ||
HPRD : 10318 | ||
Vega : OTTHUMG00000156749 | ||
Protein | UniProt: Q9Y2L8 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZKSCAN5 | |
BioGPS: 23660 | ||
Pathway | NCI Pathway Interaction Database: ZKSCAN5 | |
KEGG: ZKSCAN5 | ||
REACTOME: ZKSCAN5 | ||
Pathway Commons: ZKSCAN5 | ||
Context | iHOP: ZKSCAN5 | |
ligand binding site mutation search in PubMed: ZKSCAN5 | ||
UCL Cancer Institute: ZKSCAN5 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZKSCAN5 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H364 | R365W | BLCA | 1 | C638 | E637K | COAD | 1 | C435 | G436E | COAD | 1 | H452,H448 | K450Q | HNSC | 1 | H392 | R394H | UCEC | 1 | H368 | G370E | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZKSCAN5 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H392 | R394H | -1.5443788 | C638 | E637K | -1.0312796 | H452 | K450Q | -0.80868917 | H448 | K450Q | -0.80868917 | C435 | G436E | -0.68932197 | H368 | G370E | -0.21054884 | H364 | R365W | -0.14634385 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ZKSCAN5 from PDB |
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Differential gene expression and gene-gene network for ZKSCAN5 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ZKSCAN5 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZKSCAN5 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ZKSCAN5 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ZKSCAN5 |
Multiple alignments for Q9Y2L8 in multiple species |
LBS | AA sequence | # species | Species | C348 | ERGHRCSDCGK | 2 | Homo sapiens, Pan troglodytes | C348 | ERGHRCGDCGK | 1 | Mus musculus | C351 | HRCSDCGKFFL | 2 | Homo sapiens, Pan troglodytes | C351 | HRCGDCGKFFL | 1 | Mus musculus | C376 | EKPFKCGECGK | 3 | Homo sapiens, Pan troglodytes, Mus musculus | C379 | FKCGECGKSYN | 3 | Homo sapiens, Pan troglodytes, Mus musculus | C404 | EKPYKCQVCGK | 3 | Homo sapiens, Pan troglodytes, Mus musculus | C407 | YKCQVCGKAFR | 3 | Homo sapiens, Pan troglodytes, Mus musculus | C432 | ERPYGCNECGK | 3 | Homo sapiens, Pan troglodytes, Mus musculus | C435 | YGCNECGKNFG | 2 | Homo sapiens, Pan troglodytes | C435 | YGCNECGKSFG | 1 | Mus musculus | C554 | HKCNECGKSFI | 2 | Homo sapiens, Pan troglodytes | C554 | HQCNECGKSFI | 1 | Mus musculus | C638 | FKCNECGKGFG | 3 | Homo sapiens, Pan troglodytes, Mus musculus | C663 | EKSHQCRECGE | 2 | Homo sapiens, Pan troglodytes | C663 | DKSHQCHECGE | 1 | Mus musculus | C666 | HQCRECGEIFF | 2 | Homo sapiens, Pan troglodytes | C666 | HQCHECGEIFF | 1 | Mus musculus | C775 | TKSHQCHECGR | 2 | Homo sapiens, Pan troglodytes | C775 | GKSHQCNECGR | 1 | Mus musculus | C778 | HQCHECGRGFT | 2 | Homo sapiens, Pan troglodytes | C778 | HQCNECGRGFS | 1 | Mus musculus | C803 | EKPFQCKECGM | 2 | Homo sapiens, Pan troglodytes | C803 | EKPLQCKECGM | 1 | Mus musculus | C806 | FQCKECGMNFS | 2 | Homo sapiens, Pan troglodytes | C806 | LQCKECGMSFS | 1 | Mus musculus | H364 | SNFIQHRRIHT | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H368 | QHRRIHTGEKP | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H392 | VHLTQHQRVHT | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H420 | SHLVQHHSVHS | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H424 | QHHSVHSGERP | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H448 | SHLIEHLKRHF | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H452 | EHLKRHFREKS | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H567 | AHLIQHQRIHT | 2 | Homo sapiens, Pan troglodytes | H567 | AHLIQHRRIHT | 1 | Mus musculus | H651 | SHLAGHLRLHS | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H655 | GHLRLHSREKS | 2 | Homo sapiens, Pan troglodytes | H655 | GHLRLHSRDKS | 1 | Mus musculus | H679 | VSLIEHQVLHM | 2 | Homo sapiens, Pan troglodytes | H679 | VSLLEHQVLHV | 1 | Mus musculus | H683 | EHQVLHMGQKN | 2 | Homo sapiens, Pan troglodytes | H683 | EHQVLHVGQKS | 1 | Mus musculus | H819 | CSLFKHLRSHE | 3 | Homo sapiens, Pan troglodytes, Mus musculus | H823 | KHLRSHERTDP | 3 | Homo sapiens, Pan troglodytes, Mus musculus | V406 | PYKCQVCGKAF | 3 | Homo sapiens, Pan troglodytes, Mus musculus |
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