mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZKSCAN5
Gene summary
Basic gene Info.Gene symbolZKSCAN5
Gene namezinc finger with KRAB and SCAN domains 5
CytomapUCSC genome browser: 7q22
Type of geneprotein-coding
Descriptionzfp-95zinc finger protein 95 homologzinc finger protein homologous to Zfp95 in mousezinc finger protein with KRAB and SCAN domains 5
Modification date20141211
dbXrefs MIM : 611272
Ensembl : ENSG00000196652
HPRD : 10318
Vega : OTTHUMG00000156749
ProteinUniProt: Q9Y2L8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZKSCAN5
BioGPS: 23660
PathwayNCI Pathway Interaction Database: ZKSCAN5
Pathway Commons: ZKSCAN5
ContextiHOP: ZKSCAN5
ligand binding site mutation search in PubMed: ZKSCAN5
UCL Cancer Institute: ZKSCAN5
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ZKSCAN5

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ZKSCAN5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZKSCAN5 from PDB

Differential gene expression and gene-gene network for ZKSCAN5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZKSCAN5 and the right PPI network was created from samples without mutations in the LBS of ZKSCAN5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ZKSCAN5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ZKSCAN5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZKSCAN5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ZKSCAN5
Multiple alignments for Q9Y2L8 in multiple species
LBSAA sequence# speciesSpecies
C348ERGHRCSDCGK2Homo sapiens, Pan troglodytes
C348ERGHRCGDCGK1Mus musculus
C351HRCSDCGKFFL2Homo sapiens, Pan troglodytes
C351HRCGDCGKFFL1Mus musculus
C376EKPFKCGECGK3Homo sapiens, Pan troglodytes, Mus musculus
C379FKCGECGKSYN3Homo sapiens, Pan troglodytes, Mus musculus
C404EKPYKCQVCGK3Homo sapiens, Pan troglodytes, Mus musculus
C407YKCQVCGKAFR3Homo sapiens, Pan troglodytes, Mus musculus
C432ERPYGCNECGK3Homo sapiens, Pan troglodytes, Mus musculus
C435YGCNECGKNFG2Homo sapiens, Pan troglodytes
C435YGCNECGKSFG1Mus musculus
C554HKCNECGKSFI2Homo sapiens, Pan troglodytes
C554HQCNECGKSFI1Mus musculus
C638FKCNECGKGFG3Homo sapiens, Pan troglodytes, Mus musculus
C663EKSHQCRECGE2Homo sapiens, Pan troglodytes
C663DKSHQCHECGE1Mus musculus
C666HQCRECGEIFF2Homo sapiens, Pan troglodytes
C666HQCHECGEIFF1Mus musculus
C775TKSHQCHECGR2Homo sapiens, Pan troglodytes
C775GKSHQCNECGR1Mus musculus
C778HQCHECGRGFT2Homo sapiens, Pan troglodytes
C778HQCNECGRGFS1Mus musculus
C803EKPFQCKECGM2Homo sapiens, Pan troglodytes
C803EKPLQCKECGM1Mus musculus
C806FQCKECGMNFS2Homo sapiens, Pan troglodytes
C806LQCKECGMSFS1Mus musculus
H364SNFIQHRRIHT3Homo sapiens, Pan troglodytes, Mus musculus
H368QHRRIHTGEKP3Homo sapiens, Pan troglodytes, Mus musculus
H392VHLTQHQRVHT3Homo sapiens, Pan troglodytes, Mus musculus
H420SHLVQHHSVHS3Homo sapiens, Pan troglodytes, Mus musculus
H424QHHSVHSGERP3Homo sapiens, Pan troglodytes, Mus musculus
H448SHLIEHLKRHF3Homo sapiens, Pan troglodytes, Mus musculus
H452EHLKRHFREKS3Homo sapiens, Pan troglodytes, Mus musculus
H567AHLIQHQRIHT2Homo sapiens, Pan troglodytes
H567AHLIQHRRIHT1Mus musculus
H651SHLAGHLRLHS3Homo sapiens, Pan troglodytes, Mus musculus
H655GHLRLHSREKS2Homo sapiens, Pan troglodytes
H655GHLRLHSRDKS1Mus musculus
H679VSLIEHQVLHM2Homo sapiens, Pan troglodytes
H679VSLLEHQVLHV1Mus musculus
H683EHQVLHMGQKN2Homo sapiens, Pan troglodytes
H683EHQVLHVGQKS1Mus musculus
H819CSLFKHLRSHE3Homo sapiens, Pan troglodytes, Mus musculus
H823KHLRSHERTDP3Homo sapiens, Pan troglodytes, Mus musculus
V406PYKCQVCGKAF3Homo sapiens, Pan troglodytes, Mus musculus

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