mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ALOX12
Gene summary
Basic gene Info.Gene symbolALOX12
Gene namearachidonate 12-lipoxygenase
CytomapUCSC genome browser: 17p13.1
Type of geneprotein-coding
Description12(S)-lipoxygenase12S-lipoxygenasearachidonate 12-lipoxygenase, 12S-typelipoxin synthase 12-LOplatelet 12-LOXplatelet-type 12-lipoxygenaseplatelet-type lipoxygenase 12
Modification date20141211
dbXrefs MIM : 152391
Ensembl : ENSG00000108839
HPRD : 01066
Vega : OTTHUMG00000102088
ProteinUniProt: P18054
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALOX12
BioGPS: 239
PathwayNCI Pathway Interaction Database: ALOX12
Pathway Commons: ALOX12
ContextiHOP: ALOX12
ligand binding site mutation search in PubMed: ALOX12
UCL Cancer Institute: ALOX12
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0019369arachidonic acid metabolic process1851637
GO:0019372lipoxygenase pathway8319693
GO:0043651linoleic acid metabolic process8319693
GO:0043651linoleic acid metabolic process1851637
GO:1901751leukotriene A4 metabolic process8250832
GO:1901751leukotriene A4 metabolic process1851637
GO:2001303lipoxin A4 biosynthetic process8250832
GO:2001306lipoxin B4 biosynthetic process8250832

Ligand binding site mutations for ALOX12

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ALOX12
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ALOX12 from PDB

Differential gene expression and gene-gene network for ALOX12
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ALOX12 and the right PPI network was created from samples without mutations in the LBS of ALOX12. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ALOX12
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0006435Burns, Chemical1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker
umls:C0037274Skin Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ALOX12
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ALOX12 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ALOX12
Multiple alignments for P18054 in multiple species
LBSAA sequence# speciesSpecies

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