mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ALOX5
Gene summary
Basic gene Info.Gene symbolALOX5
Gene namearachidonate 5-lipoxygenase
CytomapUCSC genome browser: 10q11.2
Type of geneprotein-coding
DescriptionLOX-5arachidonic 5-lipoxygenase alpha-10 isoformarachidonic 5-lipoxygenase delta-10-13 isoformarachidonic 5-lipoxygenase delta-13 isoformarachidonic 5-lipoxygenase delta-p10 isoformarachidonic acid 5-lipoxygenaseleukotriene A4 synthase
Modification date20141207
dbXrefs MIM : 152390
Ensembl : ENSG00000012779
HPRD : 01065
Vega : OTTHUMG00000018081
ProteinUniProt: P09917
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALOX5
BioGPS: 240
PathwayNCI Pathway Interaction Database: ALOX5
Pathway Commons: ALOX5
ContextiHOP: ALOX5
ligand binding site mutation search in PubMed: ALOX5
UCL Cancer Institute: ALOX5
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0019370leukotriene biosynthetic process21233389

Ligand binding site mutations for ALOX5

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ALOX5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ALOX5 from PDB

Differential gene expression and gene-gene network for ALOX5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ALOX5 and the right PPI network was created from samples without mutations in the LBS of ALOX5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ALOX5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004096Asthma32Biomarker, GeneticVariation
umls:C0004153Atherosclerosis18Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms5AlteredExpression, Biomarker, GeneticVariation
umls:C0023473Leukemia, Myelogenous, Chronic, BCR-ABL Positive5Biomarker, Therapeutic
umls:C0003873Arthritis, Rheumatoid4Biomarker
umls:C0027627Neoplasm Metastasis4Biomarker
umls:C0035126Reperfusion Injury3Biomarker
umls:C0042109Urticaria3Biomarker, GeneticVariation
umls:C0020542Hypertension, Pulmonary2Biomarker
umls:C0009376Colonic Polyps2Biomarker, GeneticVariation
umls:C0011609Drug Eruptions1Biomarker
umls:C0016659Fractures, Closed1Biomarker
umls:C0740392Infarction, Middle Cerebral Artery1Biomarker
umls:C0026766Multiple Organ Failure1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ALOX5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceutical|vet_approvedDB00163Vitamin ESmall molecule
ApprovedDB00179MasoprocolSmall molecule
ApprovedDB00233Aminosalicylic AcidSmall molecule
ApprovedDB00244MesalazineSmall molecule
ApprovedDB00471MontelukastSmall molecule
Approved|vet_approvedDB00586DiclofenacSmall molecule
Approved|vet_approvedDB00711DiethylcarbamazineSmall molecule
Approved|investigational|withdrawnDB00744ZileutonSmall molecule
ApprovedDB00795SulfasalazineSmall molecule
Approved|vet_approvedDB00939Meclofenamic acidSmall molecule
Approved|investigationalDB01014BalsalazideSmall molecule
Approved|investigationalDB01017MinocyclineSmall molecule
NutraceuticalDB01892HyperforinSmall molecule
InvestigationalDB04725LicofeloneSmall molecule
InvestigationalDB05431MLN-977Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ALOX5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ALOX5
Multiple alignments for P09917 in multiple species
LBSAA sequence# speciesSpecies
F178EKGVDFVLNYS3Homo sapiens, Mus musculus, Rattus norvegicus
F178LKMADFLGYSI2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F178LKMSDFAGYSI1Oryza sativa subsp. japonica
F178VKFSDFLAYAL1Arabidopsis thaliana
F178LKMSDFLAYAL1Arabidopsis thaliana
H368HQTITHLLRTH3Homo sapiens, Mus musculus, Rattus norvegicus
H368HQLISHWLNTH3Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
H368HQLISHWLQTH1Arabidopsis thaliana
H368HQLISHWMQTH1Arabidopsis thaliana
H373HLLRTHLVSEV3Homo sapiens, Mus musculus, Rattus norvegicus
H373HWLNTHAVMEP3Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
H373HWLQTHAVIEP1Arabidopsis thaliana
H373HWMQTHASIEP1Arabidopsis thaliana
H551TASAQHAAVNF3Homo sapiens, Mus musculus, Rattus norvegicus
H551IASALHAAVNF3Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana
H551IGSALHAAVNF1Oryza sativa subsp. japonica
H551VASALHAAVNF1Arabidopsis thaliana
I22---DYIYLSLI2Mus musculus, Rattus norvegicus
I22---DYIYLSLV1Homo sapiens
I22ITCQLVSATVA1Oryza sativa subsp. japonica
I22VTCQLISSTAV1Oryza sativa subsp. japonica
I22VTCQLVSSSLV1Oryza sativa subsp. japonica
I22VSLHLISSHQP1Arabidopsis thaliana
I22ITLRLVSSDVT1Arabidopsis thaliana
N555LHAAVNFGQYP5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
N555QHAAVNFGQYD3Homo sapiens, Mus musculus, Rattus norvegicus
Q364DFHVHQTITHL2Homo sapiens, Mus musculus
Q364DSGWHQLISHW2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Q364DFHIHQTITHL1Rattus norvegicus
Q364DYCWHQLISHW1Oryza sativa subsp. japonica
Q364DSGYHQLISHW1Arabidopsis thaliana
Q364DSGNHQLISHW1Arabidopsis thaliana

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