mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ALOX5AP
Gene summary
Basic gene Info.Gene symbolALOX5AP
Gene namearachidonate 5-lipoxygenase-activating protein
CytomapUCSC genome browser: 13q12
Type of geneprotein-coding
DescriptionMK-886-binding protein
Modification date20141222
dbXrefs MIM : 603700
Ensembl : ENSG00000132965
HPRD : 04742
Vega : OTTHUMG00000016677
ProteinUniProt: P20292
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALOX5AP
BioGPS: 241
PathwayNCI Pathway Interaction Database: ALOX5AP
Pathway Commons: ALOX5AP
ContextiHOP: ALOX5AP
ligand binding site mutation search in PubMed: ALOX5AP
UCL Cancer Institute: ALOX5AP
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0019370leukotriene biosynthetic process2300173
GO:0071277cellular response to calcium ion2300173

Ligand binding site mutations for ALOX5AP

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ALOX5AP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ALOX5AP from PDB

Differential gene expression and gene-gene network for ALOX5AP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ALOX5AP and the right PPI network was created from samples without mutations in the LBS of ALOX5AP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ALOX5AP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004153Atherosclerosis10Biomarker, GeneticVariation
umls:C0007785Cerebral Infarction5Biomarker
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0023895Liver Diseases1Biomarker
umls:C0235032Neurotoxicity Syndromes1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ALOX5AP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
InvestigationalDB04929DG031Small molecule
InvestigationalDB05225AM103Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ALOX5AP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ALOX5AP
Multiple alignments for P20292 in multiple species
LBSAA sequence# speciesSpecies
A27QNGFFAHKVEH2Homo sapiens, Bos taurus
A27QNAFFAHKVEH1Mus musculus
A27QNAFFAHKVEL1Rattus norvegicus
A63QNCVDAYPTFL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D62NQNCVDAYPTF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F114TPGYIFGKRII4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F123IILFLFLMSVA1Homo sapiens
F123IILFLFAMSLA1Bos taurus
F123IILFLFLMSFA1Mus musculus
F123IILFLFLMSLA1Rattus norvegicus
F25VVQNGFFAHKV2Homo sapiens, Bos taurus
F25VVQNAFFAHKV2Mus musculus, Rattus norvegicus
G24SVVQNGFFAHK2Homo sapiens, Bos taurus
G24SVVQNAFFAHK2Mus musculus, Rattus norvegicus
H28NGFFAHKVEHE2Homo sapiens, Bos taurus
H28NAFFAHKVEHE1Mus musculus
H28NAFFAHKVELE1Rattus norvegicus
I113STPGYIFGKRI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I119FGKRIILFLFL3Homo sapiens, Mus musculus, Rattus norvegicus
I119FGKRIILFLFA1Bos taurus
K116GYIFGKRIILF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L120GKRIILFLFLM3Homo sapiens, Mus musculus, Rattus norvegicus
L120GKRIILFLFAM1Bos taurus
N23ISVVQNGFFAH2Homo sapiens, Bos taurus
N23ISVVQNAFFAH2Mus musculus, Rattus norvegicus
N57RVYTANQNCVD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T66VDAYPTFLVVL2Mus musculus, Rattus norvegicus
T66VDAYPTFLAVL1Homo sapiens
V20VTLISVVQNGF2Homo sapiens, Bos taurus
V20VTLISVVQNAF2Mus musculus, Rattus norvegicus
V21TLISVVQNGFF2Homo sapiens, Bos taurus
V21TLISVVQNAFF2Mus musculus, Rattus norvegicus
V61ANQNCVDAYPT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y112QSTPGYIFGKR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus

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