mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STAC3
Gene summary
Basic gene Info.Gene symbolSTAC3
Gene nameSH3 and cysteine rich domain 3
CytomapUCSC genome browser: 12q13.3
Type of geneprotein-coding
DescriptionSH3 and cysteine-rich domain-containing protein 3
Modification date20141207
dbXrefs MIM : 615521
Ensembl : ENSG00000185482
HPRD : 11606
Vega : OTTHUMG00000171271
ProteinUniProt: Q96MF2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STAC3
BioGPS: 246329
PathwayNCI Pathway Interaction Database: STAC3
Pathway Commons: STAC3
ContextiHOP: STAC3
ligand binding site mutation search in PubMed: STAC3
UCL Cancer Institute: STAC3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for STAC3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for STAC3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STAC3 from PDB

Differential gene expression and gene-gene network for STAC3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STAC3 and the right PPI network was created from samples without mutations in the LBS of STAC3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for STAC3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1850625Native American myopathy1Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for STAC3
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STAC3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of STAC3
Multiple alignments for Q96MF2 in multiple species
LBSAA sequence# speciesSpecies
C103KKPKFCDVCAR4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
C106KFCDVCARMIV4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
C120KFGLRCKNCKT3Homo sapiens, Xenopus tropicalis, Mus musculus
C120KFALRCKNCKT1Danio rerio
C123LRCKNCKTNIH4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
C131NIHEHCQSYVE2Homo sapiens, Mus musculus
C131NIHHSCQSYVQ1Danio rerio
C131NIHHHCQSYVE1Xenopus tropicalis
H128CKTNIHEHCQS2Homo sapiens, Mus musculus
H128CKTNIHHSCQS1Danio rerio
H128CKTNIHHHCQS1Xenopus tropicalis
H90VNDKPHKFKDH4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus

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