mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ALOX15B
Gene summary
Basic gene Info.Gene symbolALOX15B
Gene namearachidonate 15-lipoxygenase, type B
CytomapUCSC genome browser: 17p13.1
Type of geneprotein-coding
Description15-LOX-B15S-lipoxygenasearachidonate 15-lipoxygenase 2arachidonate 15-lipoxygenase Barachidonate 15-lipoxygenase type IIarachidonate 15-lipoxygenase, second typearachidonate omega(6) lipoxygenaselinoleate 13-lipoxygenase 15-LOb
Modification date20141207
dbXrefs MIM : 603697
Ensembl : ENSG00000179593
HPRD : 04739
Vega : OTTHUMG00000108181
ProteinUniProt: O15296
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALOX15B
BioGPS: 247
PathwayNCI Pathway Interaction Database: ALOX15B
Pathway Commons: ALOX15B
ContextiHOP: ALOX15B
ligand binding site mutation search in PubMed: ALOX15B
UCL Cancer Institute: ALOX15B
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0008285negative regulation of cell proliferation11839751
GO:0019369arachidonic acid metabolic process10542053
GO:0045786negative regulation of cell cycle11839751
GO:0045926negative regulation of growth11839751

Ligand binding site mutations for ALOX15B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ALOX15B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ALOX15B from PDB

Differential gene expression and gene-gene network for ALOX15B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ALOX15B and the right PPI network was created from samples without mutations in the LBS of ALOX15B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ALOX15B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ALOX15B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ALOX15B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)4nreAN40 G42

Conservation information for LBS of ALOX15B
Multiple alignments for O15296 in multiple species
LBSAA sequence# speciesSpecies
A86PLAPDAWFCRW1Homo sapiens
A86SFRSDAWFCRW1Mus musculus
A86SFPPDAWYCRW1Rattus norvegicus
D39PLVPLDHLGKE2Mus musculus, Rattus norvegicus
D39PPLPLDNLGKE1Homo sapiens
D85GPLAPDAWFCR1Homo sapiens
D85MSFRSDAWFCR1Mus musculus
D85LSFPPDAWYCR1Rattus norvegicus
E44DHLGKEFSAGA2Mus musculus, Rattus norvegicus
E44DNLGKEFTAGA1Homo sapiens
G15TGEACGAGTWD2Mus musculus, Rattus norvegicus
G15TGEAFGAGTWD1Homo sapiens
G17EACGAGTWDKV2Mus musculus, Rattus norvegicus
G17EAFGAGTWDKV1Homo sapiens
G42PLDHLGKEFSA2Mus musculus, Rattus norvegicus
G42PLDNLGKEFTA1Homo sapiens
H373HEALTHLLHSH1Homo sapiens
H373HEAVTHLLHAH1Mus musculus
H373HEALTHLLHAH1Rattus norvegicus
H378HLLHAHLIPEV2Mus musculus, Rattus norvegicus
H378HLLHSHLLPEV1Homo sapiens
H553TCSAKHAAVSA2Homo sapiens, Rattus norvegicus
H553TCSAKHAAVSS1Mus musculus
I26KVSVSIVGTHG2Mus musculus, Rattus norvegicus
I26KVSVSIVGTRG1Homo sapiens
N40LVPLDHLGKEF2Mus musculus, Rattus norvegicus
N40PLPLDNLGKEF1Homo sapiens

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