mutLBSgeneDB |
Gene summary for SHPRH |
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Basic gene Info. | Gene symbol | SHPRH |
Gene name | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | |
Synonyms | bA545I5.2 | |
Cytomap | UCSC genome browser: 6q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001042683.2, NM_173082.3, | |
Description | 2610103K11RikE3 ubiquitin-protein ligase SHPRHSNF2, histone-linker, PHD and RING finger domain-containing helicase | |
Modification date | 20141207 | |
dbXrefs | MIM : 608048 | |
HGNC : HGNC | ||
Ensembl : ENSG00000146414 | ||
HPRD : 10476 | ||
Vega : OTTHUMG00000015750 | ||
Protein | UniProt: Q149N8 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SHPRH | |
BioGPS: 257218 | ||
Pathway | NCI Pathway Interaction Database: SHPRH | |
KEGG: SHPRH | ||
REACTOME: SHPRH | ||
Pathway Commons: SHPRH | ||
Context | iHOP: SHPRH | |
ligand binding site mutation search in PubMed: SHPRH | ||
UCL Cancer Institute: SHPRH | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0000209 | protein polyubiquitination | 17108083 |
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Ligand binding site mutations for SHPRH |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C1229 | C1229Y | COAD | 1 | C703 | F701L | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SHPRH |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C703 | F701L | -1.0655661 | C1229 | C1229Y | -0.22022696 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for SHPRH |
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Phenotype information for SHPRH |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SHPRH |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4qn1 | A | C1229 | ZN | ZINC(2+) | 2m85 | A | C703 |
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Conservation information for LBS of SHPRH |
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LBS | AA sequence | # species | Species |
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