mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRDX5
Gene summary
Basic gene Info.Gene symbolPRDX5
Gene nameperoxiredoxin 5
CytomapUCSC genome browser: 11q13
Type of geneprotein-coding
DescriptionAlu co-repressor 1TPx type VIantioxidant enzyme B166epididymis secretory protein Li 55liver tissue 2D-page spot 71Bperoxiredoxin Vperoxiredoxin-5, mitochondrialperoxisomal antioxidant enzymethioredoxin peroxidase PMP20thioredoxin reductase
Modification date20141207
dbXrefs MIM : 606583
Ensembl : ENSG00000126432
HPRD : 05958
Vega : OTTHUMG00000168805
ProteinUniProt: P30044
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRDX5
BioGPS: 25824
PathwayNCI Pathway Interaction Database: PRDX5
Pathway Commons: PRDX5
ContextiHOP: PRDX5
ligand binding site mutation search in PubMed: PRDX5
UCL Cancer Institute: PRDX5
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006979response to oxidative stress10514471
GO:0016480negative regulation of transcription from RNA polymerase III promoter10095767
GO:0032967positive regulation of collagen biosynthetic process15276323
GO:0042744hydrogen peroxide catabolic process10514471
GO:0051354negative regulation of oxidoreductase activity15280035
GO:0060785regulation of apoptosis involved in tissue homeostasis15276323
GO:0070995NADPH oxidation10751410
GO:2001057reactive nitrogen species metabolic process15280035

Ligand binding site mutations for PRDX5
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PRDX5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRDX5 from PDB

Differential gene expression and gene-gene network for PRDX5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRDX5 and the right PPI network was created from samples without mutations in the LBS of PRDX5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PRDX5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0002171Alopecia Areata1Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PRDX5

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00995AuranofinSmall molecule
ExperimentalDB03608DiminazeneSmall molecule
ApprovedDB03793Benzoic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRDX5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PRDX5
Multiple alignments for P30044 in multiple species
LBSAA sequence# speciesSpecies
C100AFTPGCSKTHL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C100AFTPTCSMSHV2Arabidopsis thaliana, Arabidopsis thaliana
C100AFTPPCS-SQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C100AFTPTCSNQHV1Oryza sativa subsp. japonica
C100AFTPTCSMKHV1Arabidopsis thaliana
F132SVNDPFVMKAW4Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
F132SVNDAFVTGEW1Homo sapiens
F132AVNDVFVTKAW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F132TVNDVFVTEEW1Bos taurus
F132SVNDVFVIEEW1Mus musculus
F132SVNDAFVTAEW1Rattus norvegicus
F173SLVSLFGNRRL2Mus musculus, Rattus norvegicus
F173KDKGL--GIRS2Arabidopsis thaliana, Arabidopsis thaliana
F173SLVSIFGNRRL1Homo sapiens
F173S--GLLGPLRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F173SLLFLFGNHRL1Bos taurus
F173SEKGL--GIRS1Oryza sativa subsp. japonica
F173KDKGL--GVRS1Arabidopsis thaliana
G99GAFTPGCSKTH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G99GAFTPTCSMSH2Arabidopsis thaliana, Arabidopsis thaliana
G99GAFTPPCS-SQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G99GAFTPTCSNQH1Oryza sativa subsp. japonica
G99GAFTPTCSMKH1Arabidopsis thaliana
I172DSLVSLFGNRR2Mus musculus, Rattus norvegicus
I172LKDKGL--GIR2Arabidopsis thaliana, Arabidopsis thaliana
I172DSLVSIFGNRR1Homo sapiens
I172AS--GLLGPLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I172DSLLFLFGNHR1Bos taurus
I172LSEKGL--GIR1Oryza sativa subsp. japonica
I172LKDKGL--GVR1Arabidopsis thaliana
L169ELDLKDKGL--3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
L169LLDDSLVSLFG2Mus musculus, Rattus norvegicus
L169LLDDSLVSIFG1Homo sapiens
L169GFDAS--GLLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L169LLDDSLLFLFG1Bos taurus
L169ELDLSEKGL--1Oryza sativa subsp. japonica
P72VFEGEPG-KKV2Mus musculus, Rattus norvegicus
P72FFDENDQLQTV2Arabidopsis thaliana, Arabidopsis thaliana
P72VFEGEPG-NKV1Homo sapiens
P72LWENKPE----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P72VFEKEPG-NKV1Bos taurus
P72WFDGEDKLQQV1Oryza sativa subsp. japonica
P72FFDENDQLQTA1Arabidopsis thaliana
P93VLFGVPGAFTP4Homo sapiens, Mus musculus, Rattus norvegicus, Oryza sativa subsp. japonica
P93ILFGVPGAFTP3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
P93IIVGVPGAFTP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P98PGAFTPGCSKT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P98PGAFTPTCSMS2Arabidopsis thaliana, Arabidopsis thaliana
P98PGAFTPPCS-S1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P98PGAFTPTCSNQ1Oryza sativa subsp. japonica
P98PGAFTPTCSMK1Arabidopsis thaliana
R180NRRLKRFSMVI2Mus musculus, Rattus norvegicus
R180GIRSRRFALLL2Arabidopsis thaliana, Arabidopsis thaliana
R180NRRLKRFSMVV1Homo sapiens
R180PLRSKRYAAVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R180NHRLKRFSMVI1Bos taurus
R180GIRSRRFALLA1Oryza sativa subsp. japonica
R180GVRSRRFALLL1Arabidopsis thaliana
T200VEPDGTGLTCS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T200VE-SGGEFTVS2Arabidopsis thaliana, Arabidopsis thaliana
T200IENEVTDVDIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T200IE-EGGQFTIS1Oryza sativa subsp. japonica
T200VE-NGGEFTVS1Arabidopsis thaliana
T97VPGAFTPGCSK3Homo sapiens, Mus musculus, Rattus norvegicus
T97VPGAFTPTCSM3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T97VPGAFTPPCS-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T97VPGAFTPTCSN1Oryza sativa subsp. japonica

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas