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mutLBSgeneDB |
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| Gene summary for RAB26 |
 Gene summary |
| Basic gene Info. | Gene symbol | RAB26 |
| Gene name | RAB26, member RAS oncogene family | |
| Synonyms | V46133 | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014353.4, | |
| Description | Ras-related oncogene proteinras-related protein Rab-26 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605455 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167964 | ||
| HPRD : 05676 | ||
| Vega : OTTHUMG00000128829 | ||
| Protein | UniProt: Q9ULW5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RAB26 | |
| BioGPS: 25837 | ||
| Pathway | NCI Pathway Interaction Database: RAB26 | |
| KEGG: RAB26 | ||
| REACTOME: RAB26 | ||
| Pathway Commons: RAB26 | ||
| Context | iHOP: RAB26 | |
| ligand binding site mutation search in PubMed: RAB26 | ||
| UCL Cancer Institute: RAB26 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for RAB26 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F93 | T92A | COAD | 1 | F88 | A90V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RAB26 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F88 | A90V | 0.11361563 | F93 | T92A | -0.73760884 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RAB26 from PDB |
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| Differential gene expression and gene-gene network for RAB26 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RAB26 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RAB26 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RAB26 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2g6b | A | F88 F93 |
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| Conservation information for LBS of RAB26 |
| Multiple alignments for Q9ULW5 in multiple species |
| LBS | AA sequence | # species | Species | A182 | NKVDSAHERVV | 1 | Homo sapiens | A182 | NKVDSAQERAV | 1 | Bos taurus | A182 | NKVDSTQDRVV | 1 | Mus musculus | A182 | NKVDSTQERVV | 1 | Rattus norvegicus | A208 | FMETSAKTGLN | 2 | Homo sapiens, Bos taurus | A208 | FMETSARTGLN | 1 | Mus musculus | A208 | FMETSAKSGLN | 1 | Rattus norvegicus | C78 | GVGKTCLLVRF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D180 | LGNKVDSAHER | 1 | Homo sapiens | D180 | LGNKVDSAQER | 1 | Bos taurus | D180 | LGNKVDSTQDR | 1 | Mus musculus | D180 | LGNKVDSTQER | 1 | Rattus norvegicus | F88 | FKDGAFLAGTF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F93 | FLAGTFISTVG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G73 | LVGDSGVGKTC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G75 | GDSGVGKTCLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K178 | MLLGNKVDSTQ | 2 | Mus musculus, Rattus norvegicus | K178 | MLLGNKVDSAH | 1 | Homo sapiens | K178 | MLLGNKVDSAQ | 1 | Bos taurus | K209 | METSAKTGLNV | 2 | Homo sapiens, Bos taurus | K209 | METSARTGLNV | 1 | Mus musculus | K209 | METSAKSGLNV | 1 | Rattus norvegicus | K76 | DSGVGKTCLLV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N177 | LMLLGNKVDSA | 2 | Homo sapiens, Bos taurus | N177 | LMLLGNKVDST | 2 | Mus musculus, Rattus norvegicus | S207 | PFMETSAKTGL | 2 | Homo sapiens, Bos taurus | S207 | PFMETSARTGL | 1 | Mus musculus | S207 | PFMETSAKSGL | 1 | Rattus norvegicus | S72 | MLVGDSGVGKT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S95 | AGTFISTVGID | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T77 | SGVGKTCLLVR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T96 | GTFISTVGIDF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V74 | VGDSGVGKTCL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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