mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for GALK2

Gene summary

Basic gene Info.	Gene symbol	GALK2
	Gene name	galactokinase 2
	Synonyms	GK2
	Cytomap	UCSC genome browser: 15q21.1-q21.2
	Type of gene	protein-coding
	RefGenes	NM_001001556.2, NM_001289030.1,NM_001289031.1,NM_002044.3,
	Description	N-acetylgalactosamine kinasegalNAc kinase
	Modification date	20141207
dbXrefs	MIM : 137028
	HGNC : HGNC
	HPRD : 00657
Protein	UniProt: Q01415 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GALK2
	BioGPS: 2585
Pathway	NCI Pathway Interaction Database: GALK2
	KEGG: GALK2
	REACTOME: GALK2
	Pathway Commons: GALK2
Context	iHOP: GALK2
	ligand binding site mutation search in PubMed: GALK2
	UCL Cancer Institute: GALK2
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for GALK2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
E49	E49K	BRCA	1
Y110	F111L	COAD	1
G401	T400A	GBM	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for GALK2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
E49	E49K	-1.3996374
Y110	F111L	-1.0972589
G401	T400A	-0.82859031

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GALK2 from PDB

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Differential gene expression and gene-gene network for GALK2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of GALK2 and the right PPI network was created from samples without mutations in the LBS of GALK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for GALK2

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0017661	Glomerulonephritis, IGA	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for GALK2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GALK2 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NG1		N-ACETYL-ALPHA-D-GALACTOSAMINE 1-PHOSPHATE(2-)	2a2c	A	E49 G401
A2G		ALPHA-GALNAC	2a2d	A	E49 G401
ADP		ADP	2a2c	A	Y110
ANP		AMP-PNP	2a2d	A	Y110

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Conservation information for LBS of GALK2

Multiple alignments for Q01415 in multiple species

LBS	AA sequence	# species	Species
A402	SRLTGAGWGGC	5	Homo sapiens, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus
A402	ARTTGAGWGGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A402	ARLTGAGWGGC	1	Arabidopsis thaliana
D190	EGGGMDQSISF	2	Homo sapiens, Rattus norvegicus
D190	NTGGMDQCASI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D190	NNGGMDQAASI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D190	NNGGMDQAASV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D190	NNGGMDQATSV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D190	QSGGMDQAISI	1	Arabidopsis thaliana
D52	IGEHIDYCGYS	2	Homo sapiens, Rattus norvegicus
D52	IGEHIDYCDFS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D52	IGEHIDYNYFS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D52	IGEHIDYCQFS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D52	IGEHIDYEGYS	1	Arabidopsis thaliana
E179	ICAKSERYIGT	2	Homo sapiens, Rattus norvegicus
E179	ISVVSEHYVGV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E179	TTAVAEHHVGV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E179	ITVVAEHYVGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E179	ITAVAEHYVGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E179	LTCECERHIGT	1	Arabidopsis thaliana
E49	VNLIGEHIDYC	3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E49	VNIIGEHIDYC	2	Homo sapiens, Rattus norvegicus
E49	VNIIGEHIDYN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E49	VNLIGEHIDYE	1	Arabidopsis thaliana
F240	TS--HFNIRVM	1	Homo sapiens
F240	TALTNYNLRVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F240	TGPVNYNLRVV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F240	TAPTNYNLRVV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F240	TAPTNYNLRVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F240	TAAKNYNNRVV	1	Arabidopsis thaliana
F240	TS--HFNVRVM	1	Rattus norvegicus
G136	NCLVDGNIPPS	2	Homo sapiens, Rattus norvegicus
G136	KLIFDGNVPTG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G136	EIYVKGDIPSG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G136	QVFCEGDVPTG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G136	QIFCQSDIPTG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G136	DVLVDGIVPTG	1	Arabidopsis thaliana
G143	IPPSSGLSSSS	2	Homo sapiens, Rattus norvegicus
G143	VPTGSGLSSSA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
G143	VPTGGGLSSSA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G143	IPSGGGLSSSA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G143	IPTGGGLSS--	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G186	YIGTEGGGMDQ	2	Homo sapiens, Rattus norvegicus
G186	YVGVNNGGMDQ	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G186	YVGVNTGGMDQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G186	HVGVNNGGMDQ	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G186	HIGTQSGGMDQ	1	Arabidopsis thaliana
G187	VGVNNGGMDQA	3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G187	IGTEGGGMDQS	2	Homo sapiens, Rattus norvegicus
G187	VGVNTGGMDQC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G187	IGTQSGGMDQA	1	Arabidopsis thaliana
G401	GSRLTGAGWGG	5	Homo sapiens, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Rattus norvegicus
G401	GARTTGAGWGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G401	GARLTGAGWGG	1	Arabidopsis thaliana
H50	NIIGEHIDYCG	2	Homo sapiens, Rattus norvegicus
H50	NLIGEHIDYCD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H50	NIIGEHIDYNY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H50	NLIGEHIDYCQ	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H50	NLIGEHIDYEG	1	Arabidopsis thaliana
K234	CVEMNKAATS-	2	Homo sapiens, Rattus norvegicus
K234	LVEANKQETAL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K234	LVVSNKAETGP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K234	LVVSNKFETAP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K234	LVKSNKFETAP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K234	LAESQKAVTAA	1	Arabidopsis thaliana
L150	SSSSALVCCAG	2	Homo sapiens, Rattus norvegicus
L150	SSSAAFCVASI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L150	SSSAAFICAVS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L150	SSSAAFICAVA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L150	SS--AFTCAAA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L150	SSSAAFVCSAT	1	Arabidopsis thaliana
M189	TEGGGMDQSIS	2	Homo sapiens, Rattus norvegicus
M189	VNNGGMDQAAS	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M189	VNTGGMDQCAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M189	VNNGGMDQATS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M189	TQSGGMDQAIS	1	Arabidopsis thaliana
M232	NSCVEMNKAAT	2	Homo sapiens, Rattus norvegicus
M232	NTLVEANKQET	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M232	NTLVVSNKAET	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M232	NTLVVSNKFET	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M232	NTLVKSNKFET	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M232	HSLAESQKAVT	1	Arabidopsis thaliana
N233	SCVEMNKAATS	2	Homo sapiens, Rattus norvegicus
N233	TLVEANKQETA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N233	TLVVSNKAETG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N233	TLVVSNKFETA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N233	TLVKSNKFETA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N233	SLAESQKAVTA	1	Arabidopsis thaliana
N83	ALQLANTNPLY	1	Homo sapiens
N83	KVELNNTNPEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N83	SITLTNHDSNF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N83	SITLINADPKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N83	SITLTNADPKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N83	QLRIANVNDKY	1	Arabidopsis thaliana
N83	TLQLANTDPLY	1	Rattus norvegicus
Q191	GGGMDQSISFL	2	Homo sapiens, Rattus norvegicus
Q191	TGGMDQCASIY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q191	NGGMDQAASIC	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q191	NGGMDQAASVC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q191	NGGMDQATSVY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q191	SGGMDQAISIM	1	Arabidopsis thaliana
R43	ARSPGRVNLIG	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
R43	VRAPGRVNIIG	2	Homo sapiens, Rattus norvegicus
R43	SRSPGRVNIIG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R43	TRSPGRVNLIG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S141	GNIPPSSGLSS	2	Homo sapiens, Rattus norvegicus
S141	GNVPTGGGLSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S141	GDIPSGGGLSS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S141	GDVPTGSGLSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S141	SDIPTGGGLSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S141	GIVPTGSGLSS	1	Arabidopsis thaliana
S142	NIPPSSGLSSS	2	Homo sapiens, Rattus norvegicus
S142	NVPTGGGLSSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S142	DIPSGGGLSSS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S142	DVPTGSGLSSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S142	DIPTGGGLSS-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S142	IVPTGSGLSSS	1	Arabidopsis thaliana
S145	PSSGLSSSSAL	2	Homo sapiens, Rattus norvegicus
S145	TGSGLSSSAAF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
S145	TGGGLSSSAAF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S145	SGGGLSSSAAF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S145	TGGGLSS--AF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S146	SSGLSSSSALV	2	Homo sapiens, Rattus norvegicus
S146	GGGLSSSAAFC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S146	GGGLSSSAAFI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S146	GSGLSSSAAFI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S146	GGGLSS--AFT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S146	GSGLSSSAAFV	1	Arabidopsis thaliana
S147	SGLSSSSALVC	2	Homo sapiens, Rattus norvegicus
S147	GGLSSSAAFCV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S147	GGLSSSAAFIC	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S147	SGLSSSAAFIC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147	GGLSS--AFTC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147	SGLSSSAAFVC	1	Arabidopsis thaliana
S148	GLSSSSALVCC	2	Homo sapiens, Rattus norvegicus
S148	GLSSSAAFICA	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S148	GLSSSAAFCVA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S148	GLSS--AFTCA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S148	GLSSSAAFVCS	1	Arabidopsis thaliana
W107	PSVSDWSNYFK	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W107	KTKPLWHNYFL	1	Homo sapiens
W107	KTHHTWGNYFR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W107	PSVSEWSNYFK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W107	LKNHKWGHYFI	1	Arabidopsis thaliana
W107	KTQPLWHNYFL	1	Rattus norvegicus
Y110	SDWSNYFKCGL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y110	PLWHNYFLCGL	1	Homo sapiens
Y110	HTWGNYFRCSM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y110	SEWSNYFKCGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y110	HKWGHYFICAY	1	Arabidopsis thaliana
Y110	PLWHNYFLCGF	1	Rattus norvegicus
Y53	GEHIDYCGYSV	2	Homo sapiens, Rattus norvegicus
Y53	GEHIDYCDFSV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y53	GEHIDYNYFSV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y53	GEHIDYCQFSV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y53	GEHIDYEGYSV	1	Arabidopsis thaliana
Y88	NADPKFAQRKF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y88	NTNPLYP----	1	Homo sapiens
Y88	NTNPEFKEEIL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y88	NHDSNFAQRKF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y88	NVNDKYT--MC	1	Arabidopsis thaliana
Y88	NTDPLYP----	1	Rattus norvegicus