mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ZNF473

Gene summary

Basic gene Info.	Gene symbol	ZNF473
	Gene name	zinc finger protein 473
	Synonyms	HZFP100\|ZN473
	Cytomap	UCSC genome browser: 19q13.33
	Type of gene	protein-coding
	RefGenes	NM_001006656.1, NM_015428.1,
	Description	zfp-100zinc finger protein 100 homologzinc finger protein ZFP100
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000142528
	HPRD : 11721
	Vega : OTTHUMG00000183054
Protein	UniProt: Q8WTR7 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ZNF473
	BioGPS: 25888
Pathway	NCI Pathway Interaction Database: ZNF473
	KEGG: ZNF473
	REACTOME: ZNF473
	Pathway Commons: ZNF473
Context	iHOP: ZNF473
	ligand binding site mutation search in PubMed: ZNF473
	UCL Cancer Institute: ZNF473
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006398	histone mRNA 3'-end processing	16714279

Top

Ligand binding site mutations for ZNF473

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
H580	Q579E	BLCA	1
C349	Y347H	COAD	1
H609	R611I	COAD	1
H836	H836N	COAD	1
C651	E650K	COAD	1
H286	H286D	HNSC	1
H286	T287S	LUSC	1
H836,H832	R834G	LUSC	1
C651	G652R	STAD	1
H609	R611K	STAD	1
H609	R611K	UCEC	1
C679	D680N	UCEC	1
H668	A669T	UCEC	1
H453,H449	R451Q	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for ZNF473

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
H836	R834G	-1.5921508
H832	R834G	-1.5921508
H609	R611K	-1.2266053
H449	R451Q	-1.1811866
H453	R451Q	-1.1811866
H286	H286D	-1.0702882
C349	Y347H	-1.0700334
C651	E650K	-1.0312796
C679	D680N	-0.89965127
H609	R611I	-0.77552983
H836	H836N	-0.70151879
C651	G652R	-0.62843072
H580	Q579E	-0.58897354
H286	T287S	-0.5426255
H668	A669T	-0.53201234

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZNF473 from PDB

Top

Differential gene expression and gene-gene network for ZNF473

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ZNF473 and the right PPI network was created from samples without mutations in the LBS of ZNF473. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for ZNF473

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

Top

Pharmacological information for ZNF473

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.