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mutLBSgeneDB |
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| Gene summary for NCR3 |
 Gene summary |
| Basic gene Info. | Gene symbol | NCR3 |
| Gene name | natural cytotoxicity triggering receptor 3 | |
| Synonyms | 1C7|CD337|LY117|MALS|NKp30 | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001145466.1, NM_001145467.1,NM_147130.2, | |
| Description | NK-p30activating NK-A1 receptoractivating natural killer receptor p30lymphocyte antigen 117natural killer cell p30-related protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611550 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000204475 | ||
| HPRD : 11384 | ||
| Vega : OTTHUMG00000031123 | ||
| Protein | UniProt: O14931 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NCR3 | |
| BioGPS: 259197 | ||
| Pathway | NCI Pathway Interaction Database: NCR3 | |
| KEGG: NCR3 | ||
| REACTOME: NCR3 | ||
| Pathway Commons: NCR3 | ||
| Context | iHOP: NCR3 | |
| ligand binding site mutation search in PubMed: NCR3 | ||
| UCL Cancer Institute: NCR3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for NCR3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E65 | V66A | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NCR3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E65 | V66A | -1.5653207 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NCR3 from PDB |
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| Differential gene expression and gene-gene network for NCR3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NCR3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0024530 | Malaria | 3 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NCR3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NCR3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 3noi | A | E65 |
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| Conservation information for LBS of NCR3 |
| Multiple alignments for O14931 in multiple species |
| LBS | AA sequence | # species | Species | A43 | PCSFNASQGRL | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | E65 | VVPGKEVRNGT | 1 | Homo sapiens | E65 | VAPGKEVRNGT | 1 | Macaca mulatta | E65 | VVPGKEVRNET | 1 | Pan troglodytes | G118 | LGLGVGTGNGT | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | K64 | EVVPGKEVRNG | 1 | Homo sapiens | K64 | EVAPGKEVRNG | 1 | Macaca mulatta | K64 | EVVPGKEVRNE | 1 | Pan troglodytes | L115 | VEVLGLGVGTG | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | Q23 | ALWVSQPPEIR | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | R47 | NASQGRLAIGS | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | S22 | CALWVSQPPEI | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | S44 | CSFNASQGRLA | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes | T119 | GLGVGTGNGTR | 3 | Homo sapiens, Macaca mulatta, Pan troglodytes |
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