mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for SAMHD1

Gene summary

Basic gene Info.	Gene symbol	SAMHD1
	Gene name	SAM domain and HD domain 1
	Synonyms	CHBL2\|DCIP\|HDDC1\|MOP-5\|SBBI88
	Cytomap	UCSC genome browser: 20pter-q12
	Type of gene	protein-coding
	RefGenes	NM_015474.3,
	Description	SAM domain and HD domain-containing protein 1dNTPasedendritic cell-derived IFNG-induced proteindeoxynucleoside triphosphate triphosphohydrolase SAMHD1monocyte protein 5
	Modification date	20141219
dbXrefs	MIM : 606754
	HGNC : HGNC
	Ensembl : ENSG00000101347
	HPRD : 08418
	Vega : OTTHUMG00000032402
Protein	UniProt: Q9Y3Z3 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_SAMHD1
	BioGPS: 25939
Pathway	NCI Pathway Interaction Database: SAMHD1
	KEGG: SAMHD1
	REACTOME: SAMHD1
	Pathway Commons: SAMHD1
Context	iHOP: SAMHD1
	ligand binding site mutation search in PubMed: SAMHD1
	UCL Cancer Institute: SAMHD1
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006203	dGTP catabolic process	24217394
GO:0046061	dATP catabolic process	24141705
GO:0051289	protein homotetramerization	24217394

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Ligand binding site mutations for SAMHD1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
V133	V133I	COAD	2
G219	D218H	BRCA	1
R145	R145Q	COAD	1
R145	R145L	COAD	1
R451	R451P	COAD	1
R366	R366H	COAD	1
K523	A525T	COAD	1
F337	A338T	COAD	1
F337	A338V	COAD	1
F337	R339S	LUAD	1
R145	Y146F	LUAD	1
R366	H364Y	LUAD	1
G324	G324E	SKCM	1
R451	R451C	SKCM	1
N119	P121S	SKCM	1
H233	W231C	STAD	1
R333	R333C	UCEC	1
D137	D137H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for SAMHD1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R145	R145Q	-1.6209246
F337	R339S	-1.4903635
N119	P121S	-1.1804671
R145	R145L	-1.0952904
K523	A525T	-1.051947
V133	V133I	-1.0424485
F337	A338T	-0.85868083
R366	R366H	-0.80151116
R333	R333C	-0.6957905
R145	Y146F	-0.69270816
H233	W231C	-0.66427106
F337	A338V	-0.61352473
G324	G324E	-0.58277244
D137	D137H	-0.54884619
G219	D218H	-0.54546174
R366	H364Y	-0.33965008
R451	R451C	-0.31313367
R451	R451P	-0.31080406

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SAMHD1 from PDB

PDB ID	PDB title	PDB structure
5AO3	Crystal structure of human SAMHD1 (amino acid residues 115-626) bound to GTP

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Differential gene expression and gene-gene network for SAMHD1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of SAMHD1 and the right PPI network was created from samples without mutations in the LBS of SAMHD1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for SAMHD1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0796126	Aicardi-Goutieres syndrome	20	Biomarker
umls:C2749659	Aicardi-Goutieres syndrome 5	1	Biomarker, GeneticVariation
umls:C0017661	Glomerulonephritis, IGA	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID	AA change	Clinical significance	Origin	Phenotype IDs
131945	R145Q	Pathogenic	Germline	GeneReviews:NBK1475 MedGen:C2749659 OMIM:612952 Orphanet:ORPHA51

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Pharmacological information for SAMHD1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SAMHD1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
GTP		GTP	5ao4	D	D137
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	D	D137 R145
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	A	D137 R145
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	B	D137 R145
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	C	D137 R145
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	B	D137 R145
GTP		GTP	4tnp	A	D137 R145
GTP		GTP	4tnp	B	D137 R145
GTP		GTP	4tnp	C	D137 R145
GTP		GTP	4tnp	D	D137 R145
GTP		GTP	4tnq	A	D137 R145
GTP		GTP	4tnq	C	D137 R145
GTP		GTP	4tnq	D	D137 R145
GTP		GTP	4tnq	B	D137 R145
GTP		GTP	4tnr	D	D137 R145
GTP		GTP	4tnr	C	D137 R145
GTP		GTP	4tnr	B	D137 R145
GTP		GTP	4tnr	A	D137 R145
GTP		GTP	4tnx	A	D137 R145
GTP		GTP	4tnx	B	D137 R145
GTP		GTP	4tnx	C	D137 R145
GTP		GTP	4tnx	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	D	D137 R145
GTP		GTP	4tnz	C	D137 R145
GTP		GTP	4tnz	A	D137 R145
GTP		GTP	4tnz	D	D137 R145
GTP		GTP	4tnz	B	D137 R145
GTP		GTP	4to0	A	D137 R145
GTP		GTP	4to0	B	D137 R145
GTP		GTP	4to0	C	D137 R145
GTP		GTP	4to0	D	D137 R145
GTP		GTP	4to1	A	D137 R145
GTP		GTP	4to1	B	D137 R145
GTP		GTP	4to1	C	D137 R145
GTP		GTP	4to1	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	D	D137 R145
GTP		GTP	4to4	A	D137 R145
GTP		GTP	4to4	B	D137 R145
GTP		GTP	4to4	C	D137 R145
GTP		GTP	4to4	D	D137 R145
GTP		GTP	4to5	A	D137 R145
GTP		GTP	4to5	C	D137 R145
GTP		GTP	4to5	D	D137 R145
GTP		GTP	4to5	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	D	D137 R145
GTP		GTP	4qg1	A	D137 R145
GTP		GTP	4qg1	B	D137 R145
GTP		GTP	4qg1	C	D137 R145
GTP		GTP	4qg1	D	D137 R145
GTP		GTP	4qg2	A	D137 R145
GTP		GTP	4qg2	B	D137 R145
GTP		GTP	4qg2	C	D137 R145
GTP		GTP	4qg2	D	D137 R145
GTP		GTP	4qg4	A	D137 R145
GTP		GTP	4qg4	B	D137 R145
GTP		GTP	4qg4	C	D137 R145
GTP		GTP	4qg4	D	D137 R145
GTP		GTP	4rxo	A	D137 R145
GTP		GTP	4rxo	B	D137 R145
GTP		GTP	4rxo	C	D137 R145
GTP		GTP	4rxo	D	D137 R145
GTP		GTP	4rxp	A	D137 R145
GTP		GTP	4rxp	B	D137 R145
GTP		GTP	4rxq	A	D137 R145
GTP		GTP	4rxq	B	D137 R145
GTP		GTP	4rxr	A	D137 R145
GTP		GTP	4rxr	B	D137 R145
GTP		GTP	4rxs	A	D137 R145
GTP		GTP	4rxs	B	D137 R145
GTP		GTP	4q7h	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	C	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	D	D137 R145
GTP		GTP	4zwg	A	D137 R145
GTP		GTP	4zwg	B	D137 R145
GTP		GTP	4zwg	C	D137 R145
GTP		GTP	4zwg	D	D137 R145
DG3		DDGTP	5ao0	A	D137 R145
DG3		DDGTP	5ao0	B	D137 R145
DG3		DDGTP	5ao1	A	D137 R145
DG3		DDGTP	5ao1	B	D137 R145
DG3		DDGTP	5ao1	C	D137 R145
DG3		DDGTP	5ao1	D	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	A	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	B	D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	D	D137 R145
GTP		GTP	5ao4	A	D137 R145
GTP		GTP	5ao4	B	D137 R145
GTP		GTP	5ao4	C	D137 R145
DG3		DDGTP	5ao1	A	G219 H233
DG3		DDGTP	5ao1	B	G219 H233
DG3		DDGTP	5ao1	C	G219 H233
DG3		DDGTP	5ao1	D	G219 H233
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	B	G324
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	D	G324
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	A	H233
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	D	H233
DUT		DUTP	4qg0	C	H233
TTP		DTTP	4rxs	A	H233
TTP		DTTP	4rxs	B	H233
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	C	H233
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	D	H233
DG3		DDGTP	5ao0	A	H233
DG3		DDGTP	5ao0	B	H233
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	A	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	B	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	C	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	D	H233 R366
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	B	H233 R366
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	C	H233 R366
DCP		DCTP	4tnp	A	H233 R366
DCP		DCTP	4tnp	B	H233 R366
DCP		DCTP	4tnp	C	H233 R366
DCP		DCTP	4tnp	D	H233 R366
DTP		DATP(4-)	4tnr	C	H233 R366
DTP		DATP(4-)	4tnr	B	H233 R366
3PO		TRIPHOSPHATE(5-)	4tnx	A	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	A	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	C	H233 R366
TTP		DTTP	4tnz	B	H233 R366
DCP		DCTP	4to0	A	H233 R366
DCP		DCTP	4to0	B	H233 R366
DCP		DCTP	4to0	C	H233 R366
DCP		DCTP	4to0	D	H233 R366
DCP		DCTP	4to1	A	H233 R366
DCP		DCTP	4to1	B	H233 R366
DCP		DCTP	4to1	C	H233 R366
DCP		DCTP	4to1	D	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	A	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	B	H233 R366
TTP		DTTP	4to2	C	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	D	H233 R366
DCP		DCTP	4to3	A	H233 R366
DCP		DCTP	4to3	B	H233 R366
DCP		DCTP	4to3	C	H233 R366
DCP		DCTP	4to3	D	H233 R366
DCP		DCTP	4to4	A	H233 R366
DCP		DCTP	4to4	B	H233 R366
DCP		DCTP	4to4	C	H233 R366
DCP		DCTP	4to4	D	H233 R366
DCP		DCTP	4to5	A	H233 R366
DCP		DCTP	4to5	C	H233 R366
DCP		DCTP	4to5	D	H233 R366
DCP		DCTP	4to5	B	H233 R366
TTP		DTTP	4to6	B	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	C	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	A	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	B	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	C	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	D	H233 R366
DCP		DCTP	4qfy	A	H233 R366
DCP		DCTP	4qfy	B	H233 R366
DCP		DCTP	4qfy	C	H233 R366
DCP		DCTP	4qfy	D	H233 R366
TTP		DTTP	4qfz	A	H233 R366
TTP		DTTP	4qfz	B	H233 R366
TTP		DTTP	4qfz	C	H233 R366
TTP		DTTP	4qfz	D	H233 R366
DUT		DUTP	4qg0	B	H233 R366
DUT		DUTP	4qg0	D	H233 R366
DTP		DATP(4-)	4qg1	A	H233 R366
DTP		DATP(4-)	4qg1	B	H233 R366
DTP		DATP(4-)	4qg1	C	H233 R366
DTP		DATP(4-)	4qg1	D	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	A	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	B	H233 R366
DTP		DATP(4-)	4zwg	A	H233 R366
DTP		DATP(4-)	4zwg	B	H233 R366
DTP		DATP(4-)	4zwg	C	H233 R366
DTP		DATP(4-)	4zwg	D	H233 R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	D	N119
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	A	N119
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	B	N119
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	C	N119
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	D	N119
DTP		DATP(4-)	4mz7	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	B	N119
DCP		DCTP	4tnp	A	N119
DCP		DCTP	4tnp	B	N119
DCP		DCTP	4tnp	C	N119
DCP		DCTP	4tnp	D	N119
TTP		DTTP	4tnq	A	N119
TTP		DTTP	4tnq	C	N119
TTP		DTTP	4tnq	D	N119
TTP		DTTP	4tnq	B	N119
DTP		DATP(4-)	4tnr	D	N119
DTP		DATP(4-)	4tnr	C	N119
DTP		DATP(4-)	4tnr	B	N119
DTP		DATP(4-)	4tnr	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	D	N119
DTP		DATP(4-)	4tny	A	N119
DTP		DATP(4-)	4tny	C	N119
DTP		DATP(4-)	4tny	B	N119
DTP		DATP(4-)	4tny	D	N119
DTP		DATP(4-)	4tnz	C	N119
DTP		DATP(4-)	4tnz	A	N119
DTP		DATP(4-)	4tnz	D	N119
DTP		DATP(4-)	4tnz	B	N119
DTP		DATP(4-)	4to0	A	N119
DTP		DATP(4-)	4to0	B	N119
DTP		DATP(4-)	4to0	C	N119
DTP		DATP(4-)	4to0	D	N119
DTP		DATP(4-)	4to1	A	N119
DTP		DATP(4-)	4to1	B	N119
DCP		DCTP	4to1	C	N119
DCP		DCTP	4to1	D	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	D	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	D	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	D	N119
TTP		DTTP	4to5	A	N119
TTP		DTTP	4to5	C	N119
TTP		DTTP	4to5	D	N119
TTP		DTTP	4to5	B	N119
DTP		DATP(4-)	4to6	A	N119
DTP		DATP(4-)	4to6	B	N119
DTP		DATP(4-)	4to6	C	N119
DTP		DATP(4-)	4to6	D	N119
DTP		DATP(4-)	4qfx	A	N119
DTP		DATP(4-)	4qfx	B	N119
DTP		DATP(4-)	4qfx	C	N119
DTP		DATP(4-)	4qfx	D	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	D	N119
TTP		DTTP	4qfz	A	N119
TTP		DTTP	4qfz	B	N119
TTP		DTTP	4qfz	C	N119
TTP		DTTP	4qfz	D	N119
DUT		DUTP	4qg0	A	N119
DUT		DUTP	4qg0	B	N119
DUT		DUTP	4qg0	C	N119
DUT		DUTP	4qg0	D	N119
DTP		DATP(4-)	4qg1	A	N119
DTP		DATP(4-)	4qg1	B	N119
DTP		DATP(4-)	4qg1	C	N119
DTP		DATP(4-)	4qg1	D	N119
DTP		DATP(4-)	4qg2	A	N119
DTP		DATP(4-)	4qg2	B	N119
DTP		DATP(4-)	4qg2	C	N119
DTP		DATP(4-)	4qg2	D	N119
DTP		DATP(4-)	4qg4	A	N119
DTP		DATP(4-)	4qg4	B	N119
DTP		DATP(4-)	4qg4	C	N119
DTP		DATP(4-)	4qg4	D	N119
DTP		DATP(4-)	4rxp	A	N119
DTP		DATP(4-)	4rxp	B	N119
DUT		DUTP	4rxq	A	N119
DUT		DUTP	4rxq	B	N119
DCP		DCTP	4rxr	A	N119
DCP		DCTP	4rxr	B	N119
TTP		DTTP	4rxs	A	N119
TTP		DTTP	4rxs	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	A	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	B	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	C	N119
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	D	N119
DTP		DATP(4-)	4zwg	A	N119
DTP		DATP(4-)	4zwg	B	N119
DTP		DATP(4-)	4zwg	C	N119
DTP		DATP(4-)	4zwg	D	N119
DTP		DATP(4-)	4tnz	D	R333 F337
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	A	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	B	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	C	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	D	R333 F337 K523
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	A	R333 F337 K523
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	B	R333 F337 K523
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	C	R333 F337 K523
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	D	R333 F337 K523
DCP		DCTP	4tnp	B	R333 F337 K523
DCP		DCTP	4tnp	C	R333 F337 K523
DTP		DATP(4-)	4tnr	D	R333 F337 K523
DTP		DATP(4-)	4tnr	C	R333 F337 K523
DTP		DATP(4-)	4tnr	B	R333 F337 K523
DTP		DATP(4-)	4tnr	A	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	A	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	C	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	D	R333 F337 K523
DTP		DATP(4-)	4tny	A	R333 F337 K523
DTP		DATP(4-)	4tny	C	R333 F337 K523
DTP		DATP(4-)	4tny	B	R333 F337 K523
DTP		DATP(4-)	4tny	D	R333 F337 K523
DTP		DATP(4-)	4tnz	C	R333 F337 K523
DTP		DATP(4-)	4tnz	A	R333 F337 K523
DTP		DATP(4-)	4tnz	B	R333 F337 K523
DTP		DATP(4-)	4to0	B	R333 F337 K523
DTP		DATP(4-)	4to0	C	R333 F337 K523
DTP		DATP(4-)	4to0	D	R333 F337 K523
DTP		DATP(4-)	4to1	A	R333 F337 K523
DTP		DATP(4-)	4to1	B	R333 F337 K523
DCP		DCTP	4to1	C	R333 F337 K523
DCP		DCTP	4to1	D	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	A	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	B	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	D	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	A	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	C	R333 F337 K523
DTP		DATP(4-)	4to6	C	R333 F337 K523
DTP		DATP(4-)	4to6	D	R333 F337 K523
DTP		DATP(4-)	4qfx	B	R333 F337 K523
DTP		DATP(4-)	4qfx	C	R333 F337 K523
DTP		DATP(4-)	4qfx	D	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	A	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	B	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	C	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	D	R333 F337 K523
TTP		DTTP	4qfz	C	R333 F337 K523
TTP		DTTP	4qfz	D	R333 F337 K523
DUT		DUTP	4qg0	D	R333 F337 K523
DTP		DATP(4-)	4qg1	B	R333 F337 K523
DTP		DATP(4-)	4qg1	C	R333 F337 K523
DTP		DATP(4-)	4qg1	D	R333 F337 K523
DTP		DATP(4-)	4qg2	A	R333 F337 K523
DTP		DATP(4-)	4qg2	B	R333 F337 K523
DTP		DATP(4-)	4qg2	C	R333 F337 K523
DTP		DATP(4-)	4qg2	D	R333 F337 K523
DTP		DATP(4-)	4qg4	A	R333 F337 K523
DTP		DATP(4-)	4qg4	B	R333 F337 K523
DTP		DATP(4-)	4qg4	C	R333 F337 K523
DTP		DATP(4-)	4qg4	D	R333 F337 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	B	R333 F337 K523
DTP		DATP(4-)	4zwg	A	R333 F337 K523
DCP		DCTP	4tnp	A	R333 K523
DCP		DCTP	4tnp	D	R333 K523
TTP		DTTP	4tnq	A	R333 K523
TTP		DTTP	4tnq	C	R333 K523
TTP		DTTP	4tnq	D	R333 K523
TTP		DTTP	4tnq	B	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tnx	B	R333 K523
DTP		DATP(4-)	4to0	A	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	A	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	B	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	C	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	D	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	C	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	B	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to4	D	R333 K523
TTP		DTTP	4to5	A	R333 K523
TTP		DTTP	4to5	C	R333 K523
TTP		DTTP	4to5	D	R333 K523
TTP		DTTP	4to5	B	R333 K523
DTP		DATP(4-)	4to6	A	R333 K523
DTP		DATP(4-)	4to6	B	R333 K523
DTP		DATP(4-)	4qfx	A	R333 K523
TTP		DTTP	4qfz	A	R333 K523
TTP		DTTP	4qfz	B	R333 K523
DUT		DUTP	4qg0	A	R333 K523
DUT		DUTP	4qg0	B	R333 K523
DUT		DUTP	4qg0	C	R333 K523
DTP		DATP(4-)	4qg1	A	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	A	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	C	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	D	R333 K523
DTP		DATP(4-)	4zwg	B	R333 K523
DTP		DATP(4-)	4zwg	C	R333 K523
DTP		DATP(4-)	4zwg	D	R333 K523
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	A	R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	B	R366
TTP		DTTP	4tnq	A	R366
TTP		DTTP	4tnq	C	R366
TTP		DTTP	4tnq	D	R366
TTP		DTTP	4tnq	B	R366
DTP		DATP(4-)	4tnr	D	R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	B	R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	D	R366
TTP		DTTP	4tnz	C	R366
TTP		DTTP	4tnz	A	R366
TTP		DTTP	4tnz	D	R366
TTP		DTTP	4to6	A	R366
TTP		DTTP	4to6	D	R366
DUT		DUTP	4qg0	A	R366
DTP		DATP(4-)	4rxp	A	R366
DTP		DATP(4-)	4rxp	B	R366
DUT		DUTP	4rxq	B	R366
DCP		DCTP	4rxr	A	R366
DCP		DCTP	4rxr	B	R366
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4bzb	D	R451
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	A	R451
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	B	R451
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	C	R451
T8T		2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE)	4bzc	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4mz7	B	R451
GTP		GTP	4tnp	A	R451
GTP		GTP	4tnp	B	R451
GTP		GTP	4tnp	C	R451
GTP		GTP	4tnp	D	R451
GTP		GTP	4tnq	A	R451
GTP		GTP	4tnq	C	R451
GTP		GTP	4tnq	D	R451
GTP		GTP	4tnq	B	R451
GTP		GTP	4tnr	D	R451
GTP		GTP	4tnr	C	R451
GTP		GTP	4tnr	B	R451
GTP		GTP	4tnr	A	R451
GTP		GTP	4tnx	A	R451
GTP		GTP	4tnx	B	R451
GTP		GTP	4tnx	C	R451
GTP		GTP	4tnx	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4tny	D	R451
GTP		GTP	4tnz	C	R451
GTP		GTP	4tnz	A	R451
GTP		GTP	4tnz	D	R451
GTP		GTP	4tnz	B	R451
GTP		GTP	4to0	A	R451
GTP		GTP	4to0	B	R451
GTP		GTP	4to0	C	R451
GTP		GTP	4to0	D	R451
GTP		GTP	4to1	A	R451
GTP		GTP	4to1	B	R451
GTP		GTP	4to1	C	R451
GTP		GTP	4to1	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to2	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to3	D	R451
GTP		GTP	4to4	A	R451
GTP		GTP	4to4	B	R451
GTP		GTP	4to4	C	R451
GTP		GTP	4to4	D	R451
GTP		GTP	4to5	A	R451
GTP		GTP	4to5	C	R451
GTP		GTP	4to5	D	R451
GTP		GTP	4to5	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4to6	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfx	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfy	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qfz	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4qg0	D	R451
GTP		GTP	4qg1	A	R451
GTP		GTP	4qg1	B	R451
GTP		GTP	4qg1	C	R451
GTP		GTP	4qg1	D	R451
GTP		GTP	4qg2	A	R451
GTP		GTP	4qg2	B	R451
GTP		GTP	4qg2	C	R451
GTP		GTP	4qg2	D	R451
GTP		GTP	4qg4	A	R451
GTP		GTP	4qg4	B	R451
GTP		GTP	4qg4	C	R451
GTP		GTP	4qg4	D	R451
GTP		GTP	4rxo	A	R451
GTP		GTP	4rxo	B	R451
GTP		GTP	4rxo	C	R451
GTP		GTP	4rxo	D	R451
GTP		GTP	4rxp	A	R451
GTP		GTP	4rxp	B	R451
GTP		GTP	4rxq	A	R451
GTP		GTP	4rxq	B	R451
GTP		GTP	4rxr	A	R451
GTP		GTP	4rxr	B	R451
GTP		GTP	4rxs	A	R451
GTP		GTP	4rxs	B	R451
GTP		GTP	4q7h	A	R451
GTP		GTP	4q7h	B	R451
GTP		GTP	4q7h	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	4zwe	D	R451
GTP		GTP	4zwg	A	R451
GTP		GTP	4zwg	B	R451
GTP		GTP	4zwg	C	R451
GTP		GTP	4zwg	D	R451
DG3		DDGTP	5ao0	A	R451
DG3		DDGTP	5ao0	B	R451
DG3		DDGTP	5ao1	A	R451
DG3		DDGTP	5ao1	B	R451
DG3		DDGTP	5ao1	C	R451
DG3		DDGTP	5ao1	D	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	A	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	B	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	C	R451
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	D	R451
GTP		GTP	5ao4	A	R451
GTP		GTP	5ao4	B	R451
GTP		GTP	5ao4	C	R451
GTP		GTP	5ao4	D	R451
GTP		GTP	4q7h	A	V133 D137 R145
GTP		GTP	4q7h	B	V133 D137 R145
DGT		2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	5ao2	C	V133 D137 R145

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Conservation information for LBS of SAMHD1

Multiple alignments for Q9Y3Z3 in multiple species

LBS	AA sequence	# species	Species
D137	LVRIIDTPQFQ	2	Homo sapiens, Gallus gallus
D137	LIRIIDTPQFQ	1	Mus musculus
D137	LMRIIDTPQFQ	1	Bos taurus
D207	AGLCHDLGHGP	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
D309	KRNGIDVDKWD	3	Homo sapiens, Mus musculus, Bos taurus
D309	KKNGIDVDKWD	1	Gallus gallus
D311	NGIDVDKWDYF	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
D319	DYFARDCHHLG	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
D330	IQNNFDYKRFI	2	Homo sapiens, Mus musculus
D330	IQNNFDYRRLI	1	Gallus gallus
D330	IQNSFDYKRFL	1	Bos taurus
E234	VKWTHEQGSVM	1	Homo sapiens
E234	LNWKHETASVE	1	Gallus gallus
E234	KKWKHEQGSIE	1	Mus musculus
E234	IKWTHEQGSVM	1	Bos taurus
F157	GGYYVFPGASH	3	Homo sapiens, Mus musculus, Bos taurus
F157	GTYFVFPGASH	1	Gallus gallus
F165	ASHNRFEHSLG	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
F213	LGHGPFSHMFD	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
F337	KRFIKFARVCE	1	Homo sapiens
F337	RRLIKFTRVCE	1	Gallus gallus
F337	KRFIKFARICE	1	Mus musculus
F337	KRFLKFARVCE	1	Bos taurus
F454	EYRNLFKYVGE	1	Homo sapiens
F454	ERRELYKFLGE	1	Gallus gallus
F454	ECRNLYKYLGE	1	Mus musculus
F454	ESRNLYKFVGE	1	Bos taurus
G151	YIKQLGGGYYV	3	Homo sapiens, Mus musculus, Bos taurus
G151	YIKQLGGTYFV	1	Gallus gallus
G219	SHMFDGRFIPL	3	Homo sapiens, Gallus gallus, Bos taurus
G219	SHMFDGRFIPR	1	Mus musculus
G324	DCHHLGIQNNF	3	Homo sapiens, Gallus gallus, Mus musculus
G324	DCHHLGIQNSF	1	Bos taurus
H125	DPIHGHIEFHP	2	Mus musculus, Bos taurus
H125	DPIHGHIELHP	1	Homo sapiens
H125	DPVHGHIEIHP	1	Gallus gallus
H167	HNRFEHSLGVG	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
H206	IAGLCHDLGHG	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
H210	CHDLGHGPFSH	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
H215	HGPFSHMFDGR	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
H233	EVKWTHEQGSV	1	Homo sapiens
H233	GLNWKHETASV	1	Gallus gallus
H233	EKKWKHEQGSI	1	Mus musculus
H233	EIKWTHEQGSV	1	Bos taurus
H370	TRNCLHRRAYQ	3	Gallus gallus, Mus musculus, Bos taurus
H370	TRNSLHRRAYQ	1	Homo sapiens
H376	RRAYQHKVGNI	3	Homo sapiens, Gallus gallus, Bos taurus
H376	RRAYQHKISNL	1	Mus musculus
I118	DTMKVINDPIH	2	Homo sapiens, Bos taurus
I118	DIMKVFNDPVH	1	Gallus gallus
I118	DLMKVFNDPIH	1	Mus musculus
I136	LLVRIIDTPQF	2	Homo sapiens, Gallus gallus
I136	LLIRIIDTPQF	1	Mus musculus
I136	LLMRIIDTPQF	1	Bos taurus
I325	CHHLGIQNNFD	3	Homo sapiens, Gallus gallus, Mus musculus
I325	CHHLGIQNSFD	1	Bos taurus
K116	HVDTMKVINDP	1	Homo sapiens
K116	A-DIMKVFNDP	1	Gallus gallus
K116	RIDLMKVFNDP	1	Mus musculus
K116	--DTMKVINDP	1	Bos taurus
K312	GIDVDKWDYFA	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
K354	ICARDKEVGNL	2	Homo sapiens, Gallus gallus
K354	ICSREKEVGNL	1	Mus musculus
K354	ICTREKEVGNL	1	Bos taurus
K377	RAYQHKVGNII	3	Homo sapiens, Gallus gallus, Bos taurus
K377	RAYQHKISNLI	1	Mus musculus
K455	YRNLFKYVGET	1	Homo sapiens
K455	RRELYKFLGET	1	Gallus gallus
K455	CRNLYKYLGET	1	Mus musculus
K455	SRNLYKFVGET	1	Bos taurus
K523	VSFYCKTAPNR	1	Homo sapiens
K523	VLFYCKADPSK	1	Gallus gallus
K523	VHFYCKSNSKQ	1	Mus musculus
K523	VRFYCKSDLSK	1	Bos taurus
L150	RYIKQLGGGYY	3	Homo sapiens, Mus musculus, Bos taurus
L150	RYIKQLGGTYF	1	Gallus gallus
L453	IEYRNLFKYVG	1	Homo sapiens
L453	IERRELYKFLG	1	Gallus gallus
L453	IECRNLYKYLG	1	Mus musculus
L453	IESRNLYKFVG	1	Bos taurus
N119	TMKVINDPIHG	2	Homo sapiens, Bos taurus
N119	IMKVFNDPVHG	1	Gallus gallus
N119	LMKVFNDPIHG	1	Mus musculus
N358	DKEVGNLYDMF	2	Homo sapiens, Gallus gallus
N358	EKEVGNLYDMF	2	Mus musculus, Bos taurus
N380	QHKVGNIIDTM	2	Homo sapiens, Bos taurus
N380	QHKVGNIIEIM	1	Gallus gallus
N380	QHKISNLIDIM	1	Mus musculus
P158	GYYVFPGASHN	3	Homo sapiens, Mus musculus, Bos taurus
P158	TYFVFPGASHN	1	Gallus gallus
Q142	DTPQFQRLRYI	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
Q149	LRYIKQLGGGY	3	Homo sapiens, Mus musculus, Bos taurus
Q149	LRYIKQLGGTY	1	Gallus gallus
Q375	HRRAYQHKVGN	3	Homo sapiens, Gallus gallus, Bos taurus
Q375	HRRAYQHKISN	1	Mus musculus
R145	QFQRLRYIKQL	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
R164	GASHNRFEHSL	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
R333	NFDYKRFIKFA	2	Homo sapiens, Mus musculus
R333	NFDYRRLIKFT	1	Gallus gallus
R333	SFDYKRFLKFA	1	Bos taurus
R352	LRICARDKEVG	1	Homo sapiens
R352	KHICARDKEVG	1	Gallus gallus
R352	KHICSREKEVG	1	Mus musculus
R352	KHICTREKEVG	1	Bos taurus
R366	DMFHTRNCLHR	3	Gallus gallus, Mus musculus, Bos taurus
R366	DMFHTRNSLHR	1	Homo sapiens
R372	NCLHRRAYQHK	3	Gallus gallus, Mus musculus, Bos taurus
R372	NSLHRRAYQHK	1	Homo sapiens
R451	KQIEYRNLFKY	1	Homo sapiens
R451	HKIERRELYKF	1	Gallus gallus
R451	RNIECRNLYKY	1	Mus musculus
R451	KKIESRNLYKF	1	Bos taurus
V117	VDTMKVINDPI	1	Homo sapiens
V117	-DIMKVFNDPV	1	Gallus gallus
V117	IDLMKVFNDPI	1	Mus musculus
V117	-DTMKVINDPI	1	Bos taurus
V133	LHPLLVRIIDT	1	Homo sapiens
V133	IHPLLVRIIDT	1	Gallus gallus
V133	FHPLLIRIIDT	1	Mus musculus
V133	FHPLLMRIIDT	1	Bos taurus
V156	GGGYYVFPGAS	3	Homo sapiens, Mus musculus, Bos taurus
V156	GGTYFVFPGAS	1	Gallus gallus
V378	AYQHKVGNIID	2	Homo sapiens, Bos taurus
V378	AYQHKVGNIIE	1	Gallus gallus
V378	AYQHKISNLID	1	Mus musculus
Y155	LGGGYYVFPGA	3	Homo sapiens, Mus musculus, Bos taurus
Y155	LGGTYFVFPGA	1	Gallus gallus
Y315	VDKWDYFARDC	4	Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
Y374	LHRRAYQHKVG	3	Homo sapiens, Gallus gallus, Bos taurus
Y374	LHRRAYQHKIS	1	Mus musculus