mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DECR2
Gene summary
Basic gene Info.Gene symbolDECR2
Gene name2,4-dienoyl CoA reductase 2, peroxisomal
SynonymsPDCR|SDR17C1
CytomapUCSC genome browser: 16p13.3
Type of geneprotein-coding
RefGenesNM_020664.3,
Description2,4-dienoyl-CoA reductase 2peroxisomal 2,4-dienoyl-CoA reductaseshort chain dehydrogenase/reductase family 17C, member 1
Modification date20141207
dbXrefs MIM : 615839
HGNC : HGNC
Ensembl : ENSG00000242612
HPRD : 16789
Vega : OTTHUMG00000047846
ProteinUniProt: Q9NUI1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DECR2
BioGPS: 26063
PathwayNCI Pathway Interaction Database: DECR2
KEGG: DECR2
REACTOME: DECR2
Pathway Commons: DECR2
ContextiHOP: DECR2
ligand binding site mutation search in PubMed: DECR2
UCL Cancer Institute: DECR2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006636unsaturated fatty acid biosynthetic process11514237


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Ligand binding site mutations for DECR2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R64R64QCOAD1
I40F42LGBM1
L220G221DLUSC1
T132V133ELUSC1
C113I111VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DECR2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T132V133E-1.2727757
C113I111V-1.2504536
R64R64Q-0.71508188
L220G221D-0.47170252
I40F42L-0.4005884
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DECR2 from PDB

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Differential gene expression and gene-gene network for DECR2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DECR2 and the right PPI network was created from samples without mutations in the LBS of DECR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DECR2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DECR2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DECR2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAPNADP ZWITTERION4fc6AI40 R64 C113
NAPNADP ZWITTERION4fc6BI40 R64 C113
NAPNADP ZWITTERION4fc6CI40 R64 C113
NAPNADP ZWITTERION4fc6DI40 R64 C113
NAPNADP ZWITTERION4fc7AI40 R64 C113
NAPNADP ZWITTERION4fc7BI40 R64 C113
NAPNADP ZWITTERION4fc7CI40 R64 C113
NAPNADP ZWITTERION4fc7DI40 R64 C113
COACOENZYME A4fc7AT132
COACOENZYME A4fc7BT132
COACOENZYME A4fc7CT132
COACOENZYME A4fc7DT132
HXCHEXANOYL-COA(4-)4fc6AT132 L220
HXCHEXANOYL-COA(4-)4fc6BT132 L220
HXCHEXANOYL-COA(4-)4fc6CT132 L220
HXCHEXANOYL-COA(4-)4fc6DT132 L220


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Conservation information for LBS of DECR2
Multiple alignments for Q9NUI1 in multiple species
LBSAA sequence# speciesSpecies
A114ILINCAAGNFL3Homo sapiens, Mus musculus, Rattus norvegicus
A114FVIAGAAGNFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A114ILVNAAAGNFL1Arabidopsis thaliana
A114ILINNAAGNFL1Danio rerio
A115LINCAAGNFLC3Homo sapiens, Mus musculus, Rattus norvegicus
A115VIAGAAGNFVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A115LVNAAAGNFLA1Arabidopsis thaliana
A115LINNAAGNFLC1Danio rerio
A129ALSFNAFKTVV2Mus musculus, Rattus norvegicus
A129ALSFNAFKTVM1Homo sapiens
A129NLSPNAFKSVV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A129DLSPNGFRTVL1Arabidopsis thaliana
A129SLSFNAFKTVM1Danio rerio
A165IVNITATLSMR2Mus musculus, Rattus norvegicus
A165IVNITATLGNR1Homo sapiens
A165ILFVSATFHYY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A165IINISATLHYT1Arabidopsis thaliana
A165IVNISATLGYR1Danio rerio
C113DILINCAAGNF2Homo sapiens, Rattus norvegicus
C113DFVIAGAAGNF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C113DILVNAAAGNF1Arabidopsis thaliana
C113DILINNAAGNF1Danio rerio
C113NILINCAAGNF1Mus musculus
C120AGNFLCPASAL2Mus musculus, Rattus norvegicus
C120AGNFLCPAGAL1Homo sapiens
C120AGNFVCDFANL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C120AGNFLAAAEDL1Arabidopsis thaliana
C120AGNFLCPATSL1Danio rerio
D86SM---DVRVPP2Mus musculus, Rattus norvegicus
D86SM---DVRAPP1Homo sapiens
D86AIANVDVRNFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D86EG---DVRKQE1Arabidopsis thaliana
D86AM---DVRQPE1Danio rerio
E215AISGTEGLRRL2Mus musculus, Rattus norvegicus
E215PISGTEGLRRL1Homo sapiens
E215AIDNTEGLKRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E215PIGGTPGMSKL1Arabidopsis thaliana
E215PISGTEGYRRL1Danio rerio
F118CAAGNFLCPAS2Mus musculus, Rattus norvegicus
F118CAAGNFLCPAG1Homo sapiens
F118GAAGNFVCDFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F118AAAGNFLAAAE1Arabidopsis thaliana
F118NAAGNFLCPAT1Danio rerio
G116INCAAGNFLCP3Homo sapiens, Mus musculus, Rattus norvegicus
G116IAGAAGNFVCD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G116VNAAAGNFLAA1Arabidopsis thaliana
G116INNAAGNFLCP1Danio rerio
G209NSLAPGAISGT2Mus musculus, Rattus norvegicus
G209NSLAPGPISGT1Homo sapiens
G209NCIAPGAIDNT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G209NGIAPGPIGGT1Arabidopsis thaliana
G209NTVAPGPISGT1Danio rerio
G216ISGTEGLRRLG2Homo sapiens, Rattus norvegicus
G216IDNTEGLKRLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G216IGGTPGMSKLV1Arabidopsis thaliana
G216ISGTEGYRRLG1Danio rerio
G216ISGTEGLRRLR1Mus musculus
G35VAFITGGGSGI4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G35VAFVTGGAGTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G35VALITGGGSGI1Arabidopsis thaliana
G39TGGGSGIGFRI4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G39TGGAGTICRVQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G39TGGGSGIGFEI1Arabidopsis thaliana
I136KTVMDIDTSGT1Homo sapiens
I136KSVVDIDLLGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I136RTVLDIDAVGT1Arabidopsis thaliana
I136KTVMEIDTMGT1Danio rerio
I136KTVVDIDTIGT1Mus musculus
I136KTVVDIDTLGT1Rattus norvegicus
I163GVIVNITATLS2Mus musculus, Rattus norvegicus
I163GVIVNITATLG1Homo sapiens
I163GSILFVSATFH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I163GSIINISATLH1Arabidopsis thaliana
I163GSIVNISATLG1Danio rerio
I211LAPGAISGTEG2Mus musculus, Rattus norvegicus
I211LAPGPISGTEG1Homo sapiens
I211IAPGAIDNTEG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I211IAPGPIGGTPG1Arabidopsis thaliana
I211VAPGPISGTEG1Danio rerio
I40GGGSGIGFRIA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
I40GGAGTICRVQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I40GGGSGIGFEIS1Arabidopsis thaliana
K182HAGAAKAAVDA2Mus musculus, Rattus norvegicus
K182HAGSAKAAVDA1Homo sapiens
K182HVGAAKAGIDA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K182HVSAAKAAVDA1Arabidopsis thaliana
K182HAGSAKAANDA1Danio rerio
L167NITATLSMRGQ2Mus musculus, Rattus norvegicus
L167NITATLGNRGQ1Homo sapiens
L167FVSATFHYYGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L167NISATLHYTAS1Arabidopsis thaliana
L167NISATLGYRGQ1Danio rerio
L220EGLRRLGGPQA1Homo sapiens
L220EGLKRLAGKKY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L220PGMSKLVPEEI1Arabidopsis thaliana
L220EGYRRLGGSHA1Danio rerio
L220EGLRRLRGSNA1Mus musculus
L220EGLRRLGGPKA1Rattus norvegicus
M85CLPLSM---DV3Homo sapiens, Mus musculus, Rattus norvegicus
M85DAVLAIANVDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M85AIGLEG---DV1Arabidopsis thaliana
M85CLPIAM---DV1Danio rerio
N117NCAAGNFLCPA3Homo sapiens, Mus musculus, Rattus norvegicus
N117AGAAGNFVCDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N117NAAAGNFLAAA1Arabidopsis thaliana
N117NNAAGNFLCPA1Danio rerio
N128SALSFNAFKTV2Mus musculus, Rattus norvegicus
N128GALSFNAFKTV1Homo sapiens
N128ANLSPNAFKSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N128EDLSPNGFRTV1Arabidopsis thaliana
N128TSLSFNAFKTV1Danio rerio
P208VNSLAPGAISG2Mus musculus, Rattus norvegicus
P208VNSLAPGPISG1Homo sapiens
P208SNCIAPGAIDN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P208VNGIAPGPIGG1Arabidopsis thaliana
P208VNTVAPGPISG1Danio rerio
P210SLAPGAISGTE2Mus musculus, Rattus norvegicus
P210SLAPGPISGTE1Homo sapiens
P210CIAPGAIDNTE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P210GIAPGPIGGTP1Arabidopsis thaliana
P210TVAPGPISGTE1Danio rerio
R219TEGLRRLGGPQ1Homo sapiens
R219TEGLKRLAGKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R219TPGMSKLVPEE1Arabidopsis thaliana
R219TEGYRRLGGSH1Danio rerio
R219TEGLRRLRGSN1Mus musculus
R219TEGLRRLGGPK1Rattus norvegicus
R60TVIASRSLPRV1Homo sapiens
R60AAIVGRDQERT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R60IAIMGRRKQVL1Arabidopsis thaliana
R60TVIASRNLEKI1Danio rerio
R60TVIVGRSLQKV1Mus musculus
R60TVIVSRSLPRV1Rattus norvegicus
R64SRSLPRVLTAA1Homo sapiens
R64GRDQERTEQAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R64GRRKQVLDDAV1Arabidopsis thaliana
R64SRNLEKISQAA1Danio rerio
R64GRSLQKVTTAA1Mus musculus
R64SRSLPRVSEAA1Rattus norvegicus
R88---DVRAPPAV1Homo sapiens
R88ANVDVRNFEQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R88---DVRKQEDA1Arabidopsis thaliana
R88---DVRQPETI1Danio rerio
R88---DVRVPPEV1Mus musculus
R88---DVRVPPAV1Rattus norvegicus
S126PASALSFNAFK2Mus musculus, Rattus norvegicus
S126PAGALSFNAFK1Homo sapiens
S126DFANLSPNAFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S126AAEDLSPNGFR1Arabidopsis thaliana
S126PATSLSFNAFK1Danio rerio
S38ITGGGSGIGFR4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
S38VTGGAGTICRV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S38ITGGGSGIGFE1Arabidopsis thaliana
S59HTVIASRSLPR1Homo sapiens
S59KAAIVGRDQER1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S59SIAIMGRRKQV1Arabidopsis thaliana
S59DTVIASRNLEK1Danio rerio
S59HTVIVGRSLQK1Mus musculus
S59HTVIVSRSLPR1Rattus norvegicus
S61VIASRSLPRVL1Homo sapiens
S61AIVGRDQERTE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S61AIMGRRKQVLD1Arabidopsis thaliana
S61VIASRNLEKIS1Danio rerio
S61VIVGRSLQKVT1Mus musculus
S61VIVSRSLPRVS1Rattus norvegicus
T132FNAFKTVVDID2Mus musculus, Rattus norvegicus
T132FNAFKTVMDID1Homo sapiens
T132PNAFKSVVDID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T132PNGFRTVLDID1Arabidopsis thaliana
T132FNAFKTVMEID1Danio rerio
T164VIVNITATLSM2Mus musculus, Rattus norvegicus
T164VIVNITATLGN1Homo sapiens
T164SILFVSATFHY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T164SIINISATLHY1Arabidopsis thaliana
T164SIVNISATLGY1Danio rerio
T214GAISGTEGLRR2Mus musculus, Rattus norvegicus
T214GPISGTEGLRR1Homo sapiens
T214GAIDNTEGLKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T214GPIGGTPGMSK1Arabidopsis thaliana
T214GPISGTEGYRR1Danio rerio
V87M---DVRAPPA1Homo sapiens
V87IANVDVRNFEQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V87G---DVRKQED1Arabidopsis thaliana
V87M---DVRQPET1Danio rerio
V87M---DVRVPPE1Mus musculus
V87M---DVRVPPA1Rattus norvegicus


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