mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GARS
Gene summary
Basic gene Info.Gene symbolGARS
Gene nameglycyl-tRNA synthetase
SynonymsCMT2D|DSMAV|GlyRS|HMN5|SMAD1
CytomapUCSC genome browser: 7p15
Type of geneprotein-coding
RefGenesNM_002047.2,
DescriptionAP-4-A synthetaseCharcot-Marie-Tooth neuropathy 2DCharcot-Marie-Tooth neuropathy, neuronal type, Ddiadenosine tetraphosphate synthetaseglycine tRNA ligaseglycine--tRNA ligase
Modification date20141222
dbXrefs MIM : 600287
HGNC : HGNC
Ensembl : ENSG00000106105
HPRD : 02617
Vega : OTTHUMG00000152769
ProteinUniProt: P41250
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GARS
BioGPS: 2617
PathwayNCI Pathway Interaction Database: GARS
KEGG: GARS
REACTOME: GARS
Pathway Commons: GARS
ContextiHOP: GARS
ligand binding site mutation search in PubMed: GARS
UCL Cancer Institute: GARS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0015966diadenosine tetraphosphate biosynthetic process19710017


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Ligand binding site mutations for GARS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R213R213CSKCM2
S650D649NSKCM2
Q729E730QBLCA1
R337S338CHNSC1
D126M124ILUAD1
R464S465FSKCM1
E457I456NSTAD1
R331S329YUCEC1
R583M585TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GARS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R331S329Y0.050404134
R583M585T-1.7006784
Q729E730Q-0.82618668
E457I456N-0.79320307
S650D649N-0.58544795
R213R213C-0.52189961
R464S465F-0.50166366
R337S338C-0.15604084
D126M124I-0.079128011
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GARS from PDB
PDB IDPDB titlePDB structure
2PMEThe Apo crystal Structure of the glycyl-tRNA synthetase

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Differential gene expression and gene-gene network for GARS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GARS and the right PPI network was created from samples without mutations in the LBS of GARS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GARS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1833308Neuronopathy, Distal Hereditary Motor, Type V9Biomarker, GeneticVariation
umls:C1832274Charcot-Marie-Tooth disease, Type 2D4Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GARS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceutical|vet_approvedDB00145GlycineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GARS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of GARS
Multiple alignments for P41250 in multiple species
LBSAA sequence# speciesSpecies
A659IGRRYARTDEI3Homo sapiens, Caenorhabditis elegans, Mus musculus
A659IGKRYARTDEL1Arabidopsis thaliana
A659IGKRYARNDEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A659IGRRYARNDEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D126E----DTLKRR2Homo sapiens, Mus musculus
D126RKAVVNTLERR1Arabidopsis thaliana
D126E----SVLRGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D126E----ELMKKR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D126E----DLLKRR1Caenorhabditis elegans
D200VDKFADFMVKD2Homo sapiens, Mus musculus
D200VDKFTDLMVKD1Arabidopsis thaliana
D200VDKFSDWMCRD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D200VDKFADWMCKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D200VDRFADWMVKD1Caenorhabditis elegans
D247VLAQLDNYGQQ2Homo sapiens, Mus musculus
D247VLAVMEDFSPE1Arabidopsis thaliana
D247ILAKIDGYSGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D247ILAQIDNYDGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D247VLARLEGFDNK1Caenorhabditis elegans
D446ACDCWDAESKT2Homo sapiens, Mus musculus
D446AADCWDAEIES1Arabidopsis thaliana
D446AADCWDGELKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D446ACDCWDAEIQC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D446AQDCWDAEILT1Caenorhabditis elegans
D599E---GDEQRTF3Homo sapiens, Caenorhabditis elegans, Mus musculus
D599PSKAGDEQLNL1Arabidopsis thaliana
D599P---EDNARSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D599P---EDVNRGV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D673FGVTIDFDTVN1Homo sapiens
D673FAITVDSDT--1Arabidopsis thaliana
D673FGVTIDFESAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D673FGLTVDFETLQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D673FGITVDFDSLK1Caenorhabditis elegans
D673FGITIDFDTVN1Mus musculus
E299GYLRPETAQGI2Homo sapiens, Mus musculus
E299GYLRPETAQGQ2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E299GYMRPETAQGI1Arabidopsis thaliana
E299AFLRPETAQGI1Caenorhabditis elegans
E333NSFRNEISPRS2Homo sapiens, Mus musculus
E333QAFRNEISPRQ1Arabidopsis thaliana
E333KSFRNEISPRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E333KAFRNEISPRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E333LGFRNEISPRQ1Caenorhabditis elegans
E350EFTMAEIEHFV2Homo sapiens, Mus musculus
E350EFTLAEIEHFV1Arabidopsis thaliana
E350EFLMAEIEHFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E350EFLMAEVEHFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E350EFTMCEIEHFV1Caenorhabditis elegans
E436QHMENEMAHYA2Homo sapiens, Mus musculus
E436QHLANEMAHYA1Arabidopsis thaliana
E436QHMANEMAHYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E436QHMSNEMAHYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E436QHLSNEMAHYA1Caenorhabditis elegans
E457SYGWIEIVGCA2Homo sapiens, Mus musculus
E457SYGWIECVGCA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E457SYGWIECVGIA1Arabidopsis thaliana
E457SYGWIECVGNA1Caenorhabditis elegans
E576VPNVIEPSFGL1Homo sapiens
E576TPSVIEPSFGI1Arabidopsis thaliana
E576VPSVIEPSFGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E576TPNVIEPSFGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E576TPSVIEPSYGI1Caenorhabditis elegans
E576VPSVIEPSFGL1Mus musculus
E663YARTDEIGVAF2Homo sapiens, Mus musculus
E663YARNDELGTPF2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E663YARTDELGVPF1Arabidopsis thaliana
E663YARTDEIGIPF1Caenorhabditis elegans
F198GHVDKFADFMV2Homo sapiens, Mus musculus
F198GHVDKFTDLMV1Arabidopsis thaliana
F198GHVDKFSDWMC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F198GHVDKFADWMC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F198GHVDRFADWMV1Caenorhabditis elegans
F346IRVREFTMAEI2Homo sapiens, Mus musculus
F346LRVREFTLAEI1Arabidopsis thaliana
F346LRVREFLMAEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F346LRVREFLMAEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F346IRVREFTMCEI1Caenorhabditis elegans
F674GVTIDFDTVNK1Homo sapiens
F674AITVDSDT---1Arabidopsis thaliana
F674GVTIDFESAKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F674GLTVDFETLQN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F674GITVDFDSLKT1Caenorhabditis elegans
F674GITIDFDTVNK1Mus musculus
F726ARYPLFEGQET2Homo sapiens, Mus musculus
F726ATFPHHSSAAA1Arabidopsis thaliana
F726KDLTPFIAQAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F726AKFGEFKSTQE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F726AKYPKFEASAT1Caenorhabditis elegans
G142AFAIYGGVSGL2Homo sapiens, Mus musculus
G142SFKIYSGVAGL1Arabidopsis thaliana
G142AFDLYGGVSGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G142SFQIYGGISGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G142SFAIYGGVTGL1Caenorhabditis elegans
G143FAIYGGVSGLY2Homo sapiens, Mus musculus
G143FKIYSGVAGLF1Arabidopsis thaliana
G143FDLYGGVSGLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G143FQIYGGISGLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G143FAIYGGVTGLY1Caenorhabditis elegans
G460WIEIVGCADRS2Homo sapiens, Mus musculus
G460WIECVGCADRS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G460WIECVGIADRS1Arabidopsis thaliana
G460WIECVGNADRA1Caenorhabditis elegans
G580IEPSFGLGRIM2Homo sapiens, Mus musculus
G580IEPSFGIGRII2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G580IEPSFGLGRIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G580IEPSYGIGRIM1Caenorhabditis elegans
G655SSGSIGRRYAR2Homo sapiens, Mus musculus
G655TGTSIGKRYAR1Arabidopsis thaliana
G655SGVSIGKRYAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G655SNANIGRRYAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G655SSGTIGRRYAR1Caenorhabditis elegans
I334SFRNEISPRSG2Homo sapiens, Mus musculus
I334AFRNEISPRQG1Arabidopsis thaliana
I334SFRNEISPRAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I334AFRNEISPRSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I334GFRNEISPRQG1Caenorhabditis elegans
I341PRSGLIRVREF2Homo sapiens, Mus musculus
I341PRQGLLRVREF1Arabidopsis thaliana
I341PRAGLLRVREF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I341PRSGLLRVREF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I341PRQGLIRVREF1Caenorhabditis elegans
I458YGWIEIVGCAD2Homo sapiens, Mus musculus
I458YGWIECVGCAD2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I458YGWIECVGIAD1Arabidopsis thaliana
I458YGWIECVGNAD1Caenorhabditis elegans
I654DSSGSIGRRYA2Homo sapiens, Mus musculus
I654ITGTSIGKRYA1Arabidopsis thaliana
I654DSGVSIGKRYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I654DSNANIGRRYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I654DSSGTIGRRYA1Caenorhabditis elegans
K129--DTLKRRFFY2Homo sapiens, Mus musculus
K129VVNTLERRLFY1Arabidopsis thaliana
K129--SVLRGRFFY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K129--ELMKKRFFF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K129--DLLKRRFFY1Caenorhabditis elegans
K229KLMSDKKCSV-1Homo sapiens
K229KLEKDLTISA-1Arabidopsis thaliana
K229RLKGDQEARGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K229RLKGDKEARG-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K229KLLNDKKTSA-1Caenorhabditis elegans
K229KLMSDKKCSA-1Mus musculus
L280PVSFNLMFKTF1Homo sapiens
L280PYPFNLMFQTS1Arabidopsis thaliana
L280PRAFNLMFETA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L280PRQFNLMFETQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L280PIAFNLMFPTQ1Caenorhabditis elegans
L280PVPFNLMFQTF1Mus musculus
L340SPRSGLIRVRE2Homo sapiens, Mus musculus
L340SPRQGLLRVRE1Arabidopsis thaliana
L340SPRAGLLRVRE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L340SPRSGLLRVRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L340SPRQGLIRVRE1Caenorhabditis elegans
L621CSVLPLSQNQE2Homo sapiens, Mus musculus
L621CTVFPLVQNQQ1Arabidopsis thaliana
L621VLLVPLSNHKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L621ALIVPLSRNAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L621CSVLPISANDT1Caenorhabditis elegans
M348VREFTMAEIEH2Homo sapiens, Mus musculus
M348VREFTLAEIEH1Arabidopsis thaliana
M348VREFLMAEIEH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M348VREFLMAEVEH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M348VREFTMCEIEH1Caenorhabditis elegans
M692RDRDSMRQIRA2Homo sapiens, Mus musculus
M692RERDSTKQVRG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M692RERDSKDQVRV1Arabidopsis thaliana
M692RHAETMSQIRL1Caenorhabditis elegans
N435RQHMENEMAHY2Homo sapiens, Mus musculus
N435RQHLANEMAHY1Arabidopsis thaliana
N435RQHMANEMAHY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N435RQHMSNEMAHY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N435RQHLSNEMAHY1Caenorhabditis elegans
N624LPLSQNQEFMP2Homo sapiens, Mus musculus
N624FPLVQNQQFEE1Arabidopsis thaliana
N624VPLSNHKDLVP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N624VPLSRNAEFAP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N624LPISANDTLIP1Caenorhabditis elegans
Q136RFFYDQAFAIY2Homo sapiens, Mus musculus
Q136RLFYIPSFKIY1Arabidopsis thaliana
Q136RFFYAPAFDLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q136RFFFSPSFQIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q136RFFYDQSFAIY1Caenorhabditis elegans
Q171RQHFIQEEQIL2Homo sapiens, Mus musculus
Q171RQHFILEENML1Arabidopsis thaliana
Q171RKHFILEEDML1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q171RKHFVIEESML1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q171RKHFILEEGML1Caenorhabditis elegans
Q601--GDEQRTFFS2Homo sapiens, Mus musculus
Q601KAGDEQLNLFR1Arabidopsis thaliana
Q601--EDNARSVLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q601--EDVNRGVLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q601--GDEQRTFLA1Caenorhabditis elegans
Q623VLPLSQNQEFM2Homo sapiens, Mus musculus
Q623VFPLVQNQQFE1Arabidopsis thaliana
Q623LVPLSNHKDLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q623IVPLSRNAEFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q623VLPISANDTLI1Caenorhabditis elegans
Q694RDSMRQIRAEI1Homo sapiens
Q694RDSKDQVRVTL1Arabidopsis thaliana
Q694RDSTKQVRGSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q694RDSTKQVRGSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q694AETMSQIRLEV1Caenorhabditis elegans
Q694RDSMRQIRAEV1Mus musculus
Q729PLFEGQETGKK2Homo sapiens, Mus musculus
Q729PHHSSAAADE-1Arabidopsis thaliana
Q729TPFIAQAEAEA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q729GEFKSTQE---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q729PKFEASATE--1Caenorhabditis elegans
R121DDIVDRAKME-2Homo sapiens, Mus musculus
R121NGSLNREAFRK1Arabidopsis thaliana
R121AVPFNREQLE-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R121AAAFDRTQFE-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R121EASFDRLKLE-1Caenorhabditis elegans
R130-DTLKRRFFYD2Homo sapiens, Mus musculus
R130VNTLERRLFYI1Arabidopsis thaliana
R130-SVLRGRFFYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R130-ELMKKRFFFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R130-DLLKRRFFYD1Caenorhabditis elegans
R213NGECFRADHLL2Homo sapiens, Mus musculus
R213TGEIFRADHLV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R213TGTCYRADHLL1Arabidopsis thaliana
R213NGECFRADHLI1Caenorhabditis elegans
R331IGNSFRNEISP2Homo sapiens, Mus musculus
R331IGQAFRNEISP1Arabidopsis thaliana
R331IGKSFRNEISP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R331VGKAFRNEISP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R331IGLGFRNEISP1Caenorhabditis elegans
R337NEISPRSGLIR2Homo sapiens, Mus musculus
R337NEISPRQGLLR1Arabidopsis thaliana
R337NEISPRAGLLR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R337NEISPRSGLLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R337NEISPRQGLIR1Caenorhabditis elegans
R342RSGLIRVREFT2Homo sapiens, Mus musculus
R342RQGLLRVREFT1Arabidopsis thaliana
R342RAGLLRVREFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R342RSGLLRVREFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R342RQGLIRVREFT1Caenorhabditis elegans
R344GLIRVREFTMA2Homo sapiens, Mus musculus
R344GLLRVREFLMA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R344GLLRVREFTLA1Arabidopsis thaliana
R344GLIRVREFTMC1Caenorhabditis elegans
R464VGCADRSCYDL2Homo sapiens, Mus musculus
R464VGCADRSAYDL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R464VGIADRSAYDL1Arabidopsis thaliana
R464VGNADRACYDL1Caenorhabditis elegans
R583SFGLGRIMYTV1Homo sapiens
R583SFGIGRIIYCL1Arabidopsis thaliana
R583SFGIGRIIYSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R583SFGLGRILYVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R583SYGIGRIMYAL1Caenorhabditis elegans
R583SFGLGRIMYTI1Mus musculus
R602-GDEQRTFFSF2Homo sapiens, Mus musculus
R602AGDEQLNLFRF1Arabidopsis thaliana
R602-EDNARSVLSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R602-EDVNRGVLSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R602-GDEQRTFLAF1Caenorhabditis elegans
R656SGSIGRRYART2Homo sapiens, Mus musculus
R656GTSIGKRYART1Arabidopsis thaliana
R656GVSIGKRYARN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R656NANIGRRYARN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R656SGTIGRRYART1Caenorhabditis elegans
R660GRRYARTDEIG3Homo sapiens, Caenorhabditis elegans, Mus musculus
R660GKRYARTDELG1Arabidopsis thaliana
R660GKRYARNDELG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R660GRRYARNDELG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R687HTATLRDRDSM2Homo sapiens, Mus musculus
R687-SVTIRERDSK1Arabidopsis thaliana
R687HSVTLRERDST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R687ETITLRERDST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R687FTVTIRHAETM1Caenorhabditis elegans
S145IYGGVSGLYDF2Homo sapiens, Mus musculus
S145IYSGVAGLFDY1Arabidopsis thaliana
S145LYGGVSGLYDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S145IYGGISGLYDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S145IYGGVTGLYDF1Caenorhabditis elegans
S335FRNEISPRSGL3Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus
S335FRNEISPRQGL2Arabidopsis thaliana, Caenorhabditis elegans
S335FRNEISPRAGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S578NVIEPSFGLGR2Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S578SVIEPSFGIGR2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S578SVIEPSYGIGR1Caenorhabditis elegans
S578SVIEPSFGLGR1Mus musculus
S622SVLPLSQNQEF2Homo sapiens, Mus musculus
S622TVFPLVQNQQF1Arabidopsis thaliana
S622LLVPLSNHKDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S622LIVPLSRNAEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S622SVLPISANDTL1Caenorhabditis elegans
S650HKVDDSSGSIG2Homo sapiens, Mus musculus
S650HKIDITGTSIG1Arabidopsis thaliana
S650FKIDDSGVSIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S650NKIDDSNANIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S650YKVDDSSGTIG1Caenorhabditis elegans
S651KVDDSSGSIGR2Homo sapiens, Mus musculus
S651KIDITGTSIGK1Arabidopsis thaliana
S651KIDDSGVSIGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S651KIDDSNANIGR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S651KVDDSSGTIGR1Caenorhabditis elegans
S653DDSSGSIGRRY2Homo sapiens, Mus musculus
S653DITGTSIGKRY1Arabidopsis thaliana
S653DDSGVSIGKRY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S653DDSNANIGRRY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S653DDSSGTIGRRY1Caenorhabditis elegans
T671VAFGVTIDFDT1Homo sapiens
T671VPFAITVDSDT1Arabidopsis thaliana
T671TPFGVTIDFES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T671TPFGLTVDFET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T671IPFGITVDFDS1Caenorhabditis elegans
T671VAFGITIDFDT1Mus musculus
T685TPHTATLRDRD2Homo sapiens, Mus musculus
T685---SVTIRERD1Arabidopsis thaliana
T685--HSVTLRERD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T685--ETITLRERD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T685TPFTVTIRHAE1Caenorhabditis elegans
V144AIYGGVSGLYD2Homo sapiens, Mus musculus
V144KIYSGVAGLFD1Arabidopsis thaliana
V144DLYGGVSGLYD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V144QIYGGISGLYD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V144AIYGGVTGLYD1Caenorhabditis elegans
V343SGLIRVREFTM2Homo sapiens, Mus musculus
V343QGLLRVREFTL1Arabidopsis thaliana
V343AGLLRVREFLM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V343SGLLRVREFLM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V343QGLIRVREFTM1Caenorhabditis elegans
V459GWIEIVGCADR2Homo sapiens, Mus musculus
V459GWIECVGCADR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V459GWIECVGIADR1Arabidopsis thaliana
V459GWIECVGNADR1Caenorhabditis elegans
Y440NEMAHYACDCW3Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus
Y440NEMAHYAADCW2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y440NEMAHYAQDCW1Caenorhabditis elegans
Y658SIGRRYARTDE2Homo sapiens, Mus musculus
Y658SIGKRYARTDE1Arabidopsis thaliana
Y658SIGKRYARNDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y658NIGRRYARNDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y658TIGRRYARTDE1Caenorhabditis elegans


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