mutLBSgeneDB |
Gene summary for STAP1 |
Gene summary |
Basic gene Info. | Gene symbol | STAP1 |
Gene name | signal transducing adaptor family member 1 | |
Synonyms | BRDG1|STAP-1 | |
Cytomap | UCSC genome browser: 4q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_012108.2, | |
Description | BCR downstream signaling 1BCR downstream-signaling protein 1docking protein BRDG1signal-transducing adaptor protein 1signal-transducing adaptor protein-1stem cell adaptor protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604298 | |
HGNC : HGNC | ||
Ensembl : ENSG00000035720 | ||
HPRD : 16053 | ||
Vega : OTTHUMG00000129304 | ||
Protein | UniProt: Q9ULZ2 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STAP1 | |
BioGPS: 26228 | ||
Pathway | NCI Pathway Interaction Database: STAP1 | |
KEGG: STAP1 | ||
REACTOME: STAP1 | ||
Pathway Commons: STAP1 | ||
Context | iHOP: STAP1 | |
ligand binding site mutation search in PubMed: STAP1 | ||
UCL Cancer Institute: STAP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for STAP1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R261 | G262E | SKCM | 2 | I219 | D220H | BRCA | 1 | R184 | R184Q | COAD | 1 | Q217 | I215T | GBM | 1 | R184 | R184L | LUAD | 1 | R184 | R184G | LUAD | 1 | Y255 | I253V | STAD | 1 | I219,Q217 | E218D | UCEC | 1 | K225 | R223I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for STAP1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R261 | G262E | 0.099734634 | Q217 | E218D | -1.3198117 | I219 | E218D | -1.3198117 | Q217 | I215T | -1.1173415 | R184 | R184G | -1.0437093 | Y255 | I253V | -0.98674001 | R184 | R184Q | -0.95585607 | I219 | D220H | -0.90463703 | K225 | R223I | -0.50386043 | R184 | R184L | -0.30348713 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for STAP1 from PDB |
PDB ID | PDB title | PDB structure | 3MAZ | Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide |
Top |
Differential gene expression and gene-gene network for STAP1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for STAP1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for STAP1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of STAP1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASN,SER,TYR,GLU,ASN,VAL,LEU,ILE,ALA,LYS,NH2) | 3maz | A | R184 Q217 I219 K225 Y255 R261 |
Top |
Conservation information for LBS of STAP1 |
Multiple alignments for Q9ULZ2 in multiple species |
LBS | AA sequence | # species | Species |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |