mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CLEC4E
Gene summary
Basic gene Info.Gene symbolCLEC4E
Gene nameC-type lectin domain family 4, member E
CytomapUCSC genome browser: 12p13.31
Type of geneprotein-coding
DescriptionC-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9C-type lectin domain family 4 member EC-type lectin superfamily member 9macrophage-inducible C-type lectin
Modification date20141207
dbXrefs MIM : 609962
Ensembl : ENSG00000166523
HPRD : 13075
Vega : OTTHUMG00000168675
ProteinUniProt: Q9ULY5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CLEC4E
BioGPS: 26253
PathwayNCI Pathway Interaction Database: CLEC4E
Pathway Commons: CLEC4E
ContextiHOP: CLEC4E
ligand binding site mutation search in PubMed: CLEC4E
UCL Cancer Institute: CLEC4E
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CLEC4E

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CLEC4E
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CLEC4E from PDB

Differential gene expression and gene-gene network for CLEC4E
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CLEC4E and the right PPI network was created from samples without mutations in the LBS of CLEC4E. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CLEC4E
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0270611Brain Injuries1Biomarker
umls:C0024115Lung Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CLEC4E
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CLEC4E go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
FLCCITRATE(3-)3wh2AR183 T196
CACALCIUM(2+)3wh2AV117 E123
CACALCIUM(2+)3wh3AV117 E123

Conservation information for LBS of CLEC4E
Multiple alignments for Q9ULY5 in multiple species
LBSAA sequence# speciesSpecies
D194RQNWNDVTCFL1Homo sapiens
D194RKNWNDIPCFY1Mus musculus
D194RKNWNDVSCFF1Rattus norvegicus
E123INSQEEQEFLS1Homo sapiens
E123IDTQEEQEFLF1Mus musculus
E123INTWEEQEFLF1Rattus norvegicus
E169FWDAGEPNNIV2Mus musculus, Rattus norvegicus
E169FWDVGEPNNIA1Homo sapiens
E206MPWICEMPEIS2Mus musculus, Rattus norvegicus
E206YFRICEMVGIN1Homo sapiens
L199DVTCFLNYFRI1Homo sapiens
L199DIPCFYSMPWI1Mus musculus
L199DVSCFFSMPWI1Rattus norvegicus
N119HLVVINSQEEQ1Homo sapiens
N119HLVVIDTQEEQ1Mus musculus
N119HLVVINTWEEQ1Rattus norvegicus
N171DVGEPNNIATL1Homo sapiens
N171DAGEPNNIVLV1Mus musculus
N171DAGEPNNIVFV1Rattus norvegicus
N172VGEPNNIATLE1Homo sapiens
N172AGEPNNIVLVE1Mus musculus
N172AGEPNNIVFVE1Rattus norvegicus
N193PRQNWNDVTCF1Homo sapiens
N193SRKNWNDIPCF1Mus musculus
N193PRKNWNDVSCF1Rattus norvegicus
R183DCATMRDSSNP2Homo sapiens, Rattus norvegicus
R183DCATIRDSSNS1Mus musculus
T196NWNDVTCFLNY1Homo sapiens
T196NWNDIPCFYSM1Mus musculus
T196NWNDVSCFFSM1Rattus norvegicus
V117GAHLVVINSQE1Homo sapiens
V117GAHLVVIDTQE1Mus musculus
V117GAHLVVINTWE1Rattus norvegicus
V195QNWNDVTCFLN1Homo sapiens
V195KNWNDIPCFYS1Mus musculus
V195KNWNDVSCFFS1Rattus norvegicus

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