mutLBSgeneDB |
Gene summary for GBP1 |
![]() |
Basic gene Info. | Gene symbol | GBP1 |
Gene name | guanylate binding protein 1, interferon-inducible | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1p22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_002053.2, | |
Description | GBP-1GTP-binding protein 1guanine nucleotide-binding protein 1guanylate binding protein 1, interferon-inducible, 67kDahuGBP-1interferon-induced guanylate-binding protein 1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 600411 | |
HGNC : HGNC | ||
Ensembl : ENSG00000117228 | ||
HPRD : 02681 | ||
Vega : OTTHUMG00000010614 | ||
Protein | UniProt: P32455 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GBP1 | |
BioGPS: 2633 | ||
Pathway | NCI Pathway Interaction Database: GBP1 | |
KEGG: GBP1 | ||
REACTOME: GBP1 | ||
Pathway Commons: GBP1 | ||
Context | iHOP: GBP1 | |
ligand binding site mutation search in PubMed: GBP1 | ||
UCL Cancer Institute: GBP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for GBP1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | L67 | L67M | BLCA | 1 | S52 | S52Y | COAD | 1 | L247 | K246T | LUAD | 1 | F65 | K63R | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for GBP1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S52 | S52Y | 0.012999939 | L247 | K246T | -0.5207194 | F65 | K63R | -0.47576438 | L67 | L67M | -0.36799491 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for GBP1 |
![]() |
![]() |
Top |
Top |
Phenotype information for GBP1 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0021400 | Influenza, Human | 1 | Biomarker |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for GBP1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 1f5n | A | S52 | MG | MAGNESIUM(2+) | 2b8w | A | S52 | MG | MAGNESIUM(2+) | 2b8w | B | S52 | MG | MAGNESIUM(2+) | 2b92 | A | S52 | MG | MAGNESIUM(2+) | 2b92 | B | S52 | MG | MAGNESIUM(2+) | 2bc9 | A | S52 | 5GP | GMP RESIDUE | 2d4h | A | S52 F65 | 5GP | GMP RESIDUE | 2d4h | B | S52 F65 | 5GP | GMP RESIDUE | 2b8w | A | S52 L247 | 5GP | GMP RESIDUE | 2b8w | B | S52 L247 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1f5n | A | S52 L67 L247 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2b92 | A | S52 L67 L247 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2b92 | B | S52 L67 L247 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2bc9 | A | S52 L67 L247 |
Top |
Conservation information for LBS of GBP1 |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |