mutLBSgeneDB |
Gene summary for GCG |
Gene summary |
Basic gene Info. | Gene symbol | GCG |
Gene name | glucagon | |
Synonyms | GLP1|GLP2|GRPP | |
Cytomap | UCSC genome browser: 2q36-q37 | |
Type of gene | protein-coding | |
RefGenes | NM_002054.4, | |
Description | glicentin-related polypeptideglucagon-like peptide 1glucagon-like peptide 2preproglucagon | |
Modification date | 20141207 | |
dbXrefs | MIM : 138030 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115263 | ||
HPRD : 00676 | ||
Vega : OTTHUMG00000153892 | ||
Protein | UniProt: P01275 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GCG | |
BioGPS: 2641 | ||
Pathway | NCI Pathway Interaction Database: GCG | |
KEGG: GCG | ||
REACTOME: GCG | ||
Pathway Commons: GCG | ||
Context | iHOP: GCG | |
ligand binding site mutation search in PubMed: GCG | ||
UCL Cancer Institute: GCG | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for GCG |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | S60 | S60G | KIRC | 1 | S60 | F58V | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GCG |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S60 | S60G | -0.81857148 | S60 | F58V | -0.43951437 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for GCG from PDB |
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Differential gene expression and gene-gene network for GCG |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for GCG |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0011860 | Diabetes Mellitus, Type 2 | 80 | Biomarker, GeneticVariation |
umls:C0020456 | Hyperglycemia | 21 | Biomarker, GeneticVariation, Therapeutic |
umls:C0028754 | Obesity | 19 | Biomarker, GeneticVariation, Therapeutic |
umls:C0020459 | Hyperinsulinism | 7 | Biomarker |
umls:C0428977 | Bradycardia | 5 | Therapeutic |
umls:C0009319 | Colitis | 2 | Biomarker, Therapeutic |
umls:C0020538 | Hypertension | 2 | Biomarker |
umls:C0020649 | Hypotension | 2 | Therapeutic |
umls:C1879526 | Aberrant Crypt Foci | 1 | Biomarker |
umls:C0007370 | Catalepsy | 1 | Biomarker |
umls:C0009375 | Colonic Neoplasms | 1 | Biomarker |
umls:C0009421 | Coma | 1 | Therapeutic |
umls:C0009806 | Constipation | 1 | Biomarker |
umls:C0018799 | Heart Diseases | 1 | Therapeutic |
umls:C0018801 | Heart Failure | 1 | Therapeutic |
umls:C0424295 | Hyperkinesis | 1 | Therapeutic |
umls:C0020473 | Hyperlipidemias | 1 | Therapeutic |
umls:C0020672 | Hypothermia | 1 | Therapeutic |
umls:C0032343 | Poisoning | 1 | Therapeutic |
umls:C0037763 | Spasm | 1 | Biomarker |
umls:C0038354 | Stomach Diseases | 1 | Therapeutic |
umls:C0039231 | Tachycardia | 1 | Biomarker |
umls:C0039239 | Tachycardia, Sinus | 1 | Biomarker |
umls:C0042373 | Vascular Diseases | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GCG |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of GCG go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of GCG |
Multiple alignments for P01275 in multiple species |
LBS | AA sequence | # species | Species |
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