mutLBSgeneDB |
Gene summary for GEM |
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Basic gene Info. | Gene symbol | GEM |
Gene name | GTP binding protein overexpressed in skeletal muscle | |
Synonyms | KIR | |
Cytomap | UCSC genome browser: 8q13-q21 | |
Type of gene | protein-coding | |
RefGenes | NM_005261.3, NM_181702.2, | |
Description | GTP-binding mitogen-induced T-cell proteinGTP-binding protein GEMGTP-binding protein overexpressed in skeletal muscleRAS-like protein KIRkinase-inducible Ras-like protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 600164 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164949 | ||
HPRD : 11553 | ||
Vega : OTTHUMG00000164392 | ||
Protein | UniProt: P55040 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GEM | |
BioGPS: 2669 | ||
Pathway | NCI Pathway Interaction Database: GEM | |
KEGG: GEM | ||
REACTOME: GEM | ||
Pathway Commons: GEM | ||
Context | iHOP: GEM | |
ligand binding site mutation search in PubMed: GEM | ||
UCL Cancer Institute: GEM | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for GEM |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | L195 | V196L | KIRC | 1 | T90 | A92T | SKCM | 1 | G85 | G85E | SKCM | 1 | S221 | T220N | UCEC | 1 | L195 | R197W | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GEM |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S221 | T220N | -1.2279149 | L195 | V196L | -1.1051582 | T90 | A92T | -0.84478264 | L195 | R197W | -0.52950581 | G85 | G85E | -0.26464291 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for GEM |
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Phenotype information for GEM |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GEM |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 2cjw | A | G85 T90 L195 S221 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2cjw | B | G85 T90 L195 S221 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2g3y | A | G85 T90 L195 S221 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2ht6 | A | G85 T90 L195 S221 | GDP | GUANOSINE-5'-DIPHOSPHATE | 2ht6 | B | G85 T90 L195 S221 |
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Conservation information for LBS of GEM |
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LBS | AA sequence | # species | Species |
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