mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for 26787
Gene summary
Basic gene Info.Gene symbol26787
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt: P38159
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_26787
BioGPS: 26787
PathwayNCI Pathway Interaction Database: 26787
KEGG: 26787
REACTOME: 26787
Pathway Commons: 26787
ContextiHOP: 26787
ligand binding site mutation search in PubMed: 26787
UCL Cancer Institute: 26787
Assigned class in mutLBSgeneDB

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for 26787

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for 26787
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M40M40I-1.1601826
D5E3G-0.801607
D5D5Y-0.66713807
F51A52D-0.57797673
F53A52D-0.57797673
D5D5E-0.5742258
K9G8V-0.024664764
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for 26787 from PDB

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Differential gene expression and gene-gene network for 26787
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of 26787 and the right PPI network was created from samples without mutations in the LBS of 26787. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for 26787
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for 26787
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of 26787 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids2mb0BD5 K9 M40 F51 F53


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Conservation information for LBS of 26787
Multiple alignments for P38159 in multiple species
LBSAA sequence# speciesSpecies
A78SLDGKAIKVEQ4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
A78PLDGKPIKVEQ1Danio rerio
D55Homo sapiens, Danio rerio, Rattus norvegicus, Pan troglodytes, Mus musculus
E82KAIKVEQATKP4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
E82KPIKVEQATKP1Danio rerio
F11RPGKLFIGGLN5Homo sapiens, Danio rerio, Rattus norvegicus, Pan troglodytes, Mus musculus
F51NKSRGFAFVTF4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
F51NKSRGFAFVTY1Danio rerio
F53SRGFAFVTFES4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
F53SRGFAFVTYEN1Danio rerio
F89ATKPSFE-SGR4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
F89ATKPQFETSGR1Danio rerio
G14KLFIGGLNTET5Homo sapiens, Danio rerio, Rattus norvegicus, Pan troglodytes, Mus musculus
I79LDGKAIKVEQA4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
I79LDGKPIKVEQA1Danio rerio
K80DGKAIKVEQAT4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
K80DGKPIKVEQAT1Danio rerio
K86VEQATKPSFE-4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
K86VEQATKPQFET1Danio rerio
K9ADRPGKLFIGG5Homo sapiens, Danio rerio, Rattus norvegicus, Pan troglodytes, Mus musculus
L38RIVEVLLMKDR4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
L38RISEVLLMKDR1Danio rerio
M40VEVLLMKDRET4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
M40SEVLLMKDRET1Danio rerio
P87EQATKPSFE-S4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
P87EQATKPQFETS1Danio rerio
Q83AIKVEQATKPS4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
Q83PIKVEQATKPQ1Danio rerio
R49ETNKSRGFAFV5Homo sapiens, Danio rerio, Rattus norvegicus, Pan troglodytes, Mus musculus
S88QATKPSFE-SG4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
S88QATKPQFETSG1Danio rerio
T85KVEQATKPSFE4Homo sapiens, Rattus norvegicus, Pan troglodytes, Mus musculus
T85KVEQATKPQFE1Danio rerio


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