mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for AGO2

Gene summary

Basic gene Info.	Gene symbol	AGO2
	Gene name	argonaute RISC catalytic component 2
	Synonyms	EIF2C2\|Q10
	Cytomap	UCSC genome browser: 8q24
	Type of gene	protein-coding
	RefGenes	NM_001164623.1, NM_012154.3,
	Description	PAZ Piwi domain proteinPPDargonaute 2argonaute2eIF-2C 2eIF2C 2eukaryotic translation initiation factor 2C, 2hAgo2protein argonaute-2protein slicer
	Modification date	20141222
dbXrefs	MIM : 606229
	HGNC : HGNC
	Ensembl : ENSG00000123908
	HPRD : 06943
	Vega : OTTHUMG00000164232
Protein	UniProt: Q9UKV8 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_AGO2
	BioGPS: 27161
Pathway	NCI Pathway Interaction Database: AGO2
	KEGG: AGO2
	REACTOME: AGO2
	Pathway Commons: AGO2
Context	iHOP: AGO2
	ligand binding site mutation search in PubMed: AGO2
	UCL Cancer Institute: AGO2
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0031054	pre-miRNA processing	17671087
GO:0035278	negative regulation of translation involved in gene silencing by miRNA	17671087
GO:0035279	mRNA cleavage involved in gene silencing by miRNA	17524464
GO:0045947	negative regulation of translational initiation	17524464
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	17524464

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Ligand binding site mutations for AGO2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R277	M275I	BLCA	1
T368	T368S	BRCA	1
R277	M275T	COAD	1
F659	T657M	COAD	1
N551	K550N	HNSC	1
Y529	A530T	KIRC	1
R714	R714L	LUAD	1
R351	R351K	LUAD	1
K39	Q41H	LUAD	1
R438	R438W	LUAD	1
K709	V707M	LUAD	1
R179	F181S	LUAD	1
H753	C751F	LUAD	1
A603	G604R	LUAD	1
K709	V707G	OV	1
A620	P622S	SKCM	1
Y804	P802R	SKCM	1
L339	P340L	SKCM	1
N551	N551S	SKCM	1
T337	T337S	STAD	1
Y804	A806T	STAD	1
T526	T526M	STAD	1
R438	R438L	STAD	1
R375	D374N	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for AGO2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
K709	V707G	-1.3131811
T337	T337S	-1.1174408
N551	N551S	-1.0903071
R277	M275T	-0.89228156
A603	G604R	-0.89029523
T368	T368S	-0.86437501
R179	F181S	-0.79932131
R438	R438W	-0.74722762
Y804	P802R	-0.73234163
N551	K550N	-0.70803684
K709	V707M	-0.69570724
L339	P340L	-0.6884573
K39	Q41H	-0.63413533
R714	R714L	-0.5924017
Y529	A530T	-0.57086189
H753	C751F	-0.54005299
R277	M275I	-0.52865682
Y804	A806T	-0.49725441
T526	T526M	-0.45456175
A620	P622S	-0.43972913
R438	R438L	-0.43751192
F659	T657M	-0.40113052
R351	R351K	-0.38721939
R375	D374N	-0.35517006

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for AGO2 from PDB

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Differential gene expression and gene-gene network for AGO2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of AGO2 and the right PPI network was created from samples without mutations in the LBS of AGO2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for AGO2

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0023470	Leukemia, Myeloid	1	Biomarker
umls:C0236736	Cocaine-Related Disorders	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for AGO2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of AGO2 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
TRP		L-TRYPTOPHAN	4ei3	A	A620 F659
NUC		Nucleic Acids	4z4d	A	R179 R277 T337 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4w5q	A	R179 R375 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4w5o	A	R179 T337 L339 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4z4c	A	R179 T337 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4z4e	A	R179 T337 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4z4f	A	R179 T337 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4z4g	A	R179 T337 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4z4i	A	R179 T337 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4w5t	A	R179 T337 T526 Y529 N551 A603 K709 R714 H753 Y804
NUC		Nucleic Acids	4z4h	A	R179 T526 Y529 N551 A603 K709 H753 Y804
NUC		Nucleic Acids	4f3t	A	R277 T337 L339 R351 T368 T526 Y529 N551 K709 R714 H753 Y804
NUC		Nucleic Acids	4w5n	A	R277 T337 R351 Y529 N551 K709 R714 H753 Y804
NUC		Nucleic Acids	4w5o	A	R438
NUC		Nucleic Acids	4w5q	A	R438
NUC		Nucleic Acids	4w5r	A	R438
NUC		Nucleic Acids	4w5t	A	R438
NUC		Nucleic Acids	4z4f	A	R438
NUC		Nucleic Acids	4ei1	A	T337 L339 R351 T368 T526 Y529 N551 K709 R714 H753 Y804
NUC		Nucleic Acids	4ei3	A	T337 L339 R351 T368 T526 Y529 N551 K709 R714 H753 Y804
NUC		Nucleic Acids	4w5r	A	T337 L339 T368 T526 Y529 N551 K709 R714 H753 Y804
AMP		AMP	3lud	A	T526 Y529
AMP		AMP	3lud	B	T526 Y529
AMP		AMP	3lud	C	T526 Y529
U5P		UMP	3luj	A	T526 Y529
U5P		UMP	3luj	B	T526 Y529
U5P		UMP	3luj	C	T526 Y529
GTG		7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE	3qx8	A	T526 Y529
GTG		7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE	3qx8	B	T526 Y529
GTG		7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE	3qx8	C	T526 Y529
ATP		ATP	3qx9	A	T526 Y529
ATP		ATP	3qx9	B	T526 Y529
C5P		CMP	3lug	A	Y529
C5P		CMP	3lug	B	Y529
C5P		CMP	3lug	C	Y529
5GP		GMP RESIDUE	3luh	A	Y529
5GP		GMP RESIDUE	3luh	B	Y529
ATP		ATP	3qx9	C	Y529

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Conservation information for LBS of AGO2

Multiple alignments for Q9UKV8 in multiple species

LBS	AA sequence	# species	Species
A221	NIDVSATAFYK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
A221	NIDVSARSFYE	1	Arabidopsis thaliana
A603	VTHPPAGDGKK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
A603	VTHPQPGEDSS	1	Arabidopsis thaliana
A620	GSMD-AHPNRY	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
A620	ASMDWPEINKY	1	Arabidopsis thaliana
C546	GMATQCVQMKN	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
C546	GIVSQCCQPRQ	1	Arabidopsis thaliana
C66	IKPEKCPRRVN	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
C66	INPEVISKTVN	1	Arabidopsis thaliana
C793	HTYVRCTRSVS	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
C793	YTYARCTKSVS	1	Arabidopsis thaliana
D358	IKKLTDNQTST	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D358	TKRLNEKQVTA	1	Arabidopsis thaliana
D597	IFLGADVTHPP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D597	IIMGADVTHPQ	1	Arabidopsis thaliana
D669	IIFYRDGVSEG	6	Homo sapiens, Arabidopsis thaliana, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
E122	VTLPGE-----	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
E122	VNLAEKRADGS	1	Arabidopsis thaliana
E637	QQHRQEIIQDL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
E637	QAHREEIIQDL	1	Arabidopsis thaliana
E695	ACIKLEKDYQP	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
E695	ACNSLQENYVP	1	Arabidopsis thaliana
E695	ACIKLEKEYQP	1	Rattus norvegicus
F294	ASHQTFPLQQE	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F294	IRELRFTLEDK	1	Arabidopsis thaliana
F312	TVAQYFKDRHK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F312	TVVQYFAEKYN	1	Arabidopsis thaliana
F587	GRPPVFQQPVI	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F587	NIPLITDRPTI	1	Arabidopsis thaliana
F653	ELLIQFYKSTR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F653	EHFIAFRRATG	1	Arabidopsis thaliana
F659	YKSTRFKPTRI	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F659	RRATGQIPQRI	1	Arabidopsis thaliana
F811	AHLVAFRARYH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F811	AHLAAFRARYY	1	Arabidopsis thaliana
G123	-----GKDRIF	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G123	ADGSSGKDRPF	1	Arabidopsis thaliana
G178	RYTPVGRSFFT	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G178	DYVSVGRSFFH	1	Arabidopsis thaliana
G524	VVILPGKTPVY	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G524	IVILPDVTGSY	1	Arabidopsis thaliana
G670	IFYRDGVSEGQ	6	Homo sapiens, Arabidopsis thaliana, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
H316	YFKDRHKLVLR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
H316	YFAEKYNYRVK	1	Arabidopsis thaliana
H336	GQEQKHTYLPL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
H336	GSDTRPVYLPM	1	Arabidopsis thaliana
H600	GADVTHPPAGD	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
H600	GADVTHPQPGE	1	Arabidopsis thaliana
H753	FYLCSHAGIQG	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
H753	FYLNSHAGIQG	1	Arabidopsis thaliana
I353	AGQRCIKKLTD	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
I353	EGQRYTKRLNE	1	Arabidopsis thaliana
I365	QTSTMIRATAR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
I365	QVTALLKATCQ	1	Arabidopsis thaliana
I756	CSHAGIQGTSR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
I756	NSHAGIQGTSR	1	Arabidopsis thaliana
K124	----GKDRIFK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K124	DGSSGKDRPFK	1	Arabidopsis thaliana
K266	EIKGLKVEITH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K266	VLRTLKVKLLH	1	Arabidopsis thaliana
K278	GQMKRKYRVCN	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K278	NGTKSA-KISG	1	Arabidopsis thaliana
K335	VGQEQKHTYLP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K335	TGSDTRPVYLP	1	Arabidopsis thaliana
K39	SGRTIKLQANF	3	Homo sapiens, Xenopus tropicalis, Bos taurus
K39	TGRTIKLQANF	2	Mus musculus, Rattus norvegicus
K39	LGKKVMVRANH	1	Arabidopsis thaliana
K525	VILPGKTPVYA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K525	VILPDVTGSYG	1	Arabidopsis thaliana
K533	VYAEVKRVGDT	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K533	SYGKIKRICET	1	Arabidopsis thaliana
K566	SNLCLKINVKL	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
K566	ENVALKINVKT	1	Arabidopsis thaliana
K566	SNLWLKINVKL	1	Bos taurus
K570	LKINVKLGGVN	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K570	LKINVKTGGRN	1	Arabidopsis thaliana
K65	DIKPEKCPRRV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K65	SINPEVISKTV	1	Arabidopsis thaliana
K660	KSTRFKPTRII	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K660	RATGQIPQRII	1	Arabidopsis thaliana
K709	FIVVQKRHHTR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K709	FVIVQKRHHTR	1	Arabidopsis thaliana
K726	R--VGKSGNIP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K726	RDMTDKSGNIQ	1	Arabidopsis thaliana
L296	HQTFPLQQESG	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L296	ELRFTLEDKS-	1	Arabidopsis thaliana
L339	QKHTYLPLEVC	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L339	TRPVYLPMELC	1	Arabidopsis thaliana
L356	RCIKKLTDNQT	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L356	RYTKRLNEKQV	1	Arabidopsis thaliana
L522	LVVVILPGKTP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L522	LLIVILPDVTG	1	Arabidopsis thaliana
L563	QTLSNLCLKIN	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
L563	QYMENVALKIN	1	Arabidopsis thaliana
L563	QTLSNLWLKIN	1	Bos taurus
L650	MVRELLIQFYK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L650	LIREHFIAFRR	1	Arabidopsis thaliana
L694	EACIKLEKDYQ	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
L694	KACNSLQENYV	1	Arabidopsis thaliana
L694	EACIKLEKEYQ	1	Rattus norvegicus
M364	NQTSTMIRATA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
M364	KQVTALLKATC	1	Arabidopsis thaliana
N551	CVQMKNVQRTT	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
N551	CCQPRQVNKLN	1	Arabidopsis thaliana
N562	PQTLSNLCLKI	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
N562	KQYMENVALKI	1	Arabidopsis thaliana
N562	PQTLSNLWLKI	1	Bos taurus
P557	VQRTTPQTLSN	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P557	VNKLNKQYMEN	1	Arabidopsis thaliana
P590	PVFQQPVIFLG	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P590	LITDRPTIIMG	1	Arabidopsis thaliana
P601	ADVTHPPAGDG	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P601	ADVTHPQPGED	1	Arabidopsis thaliana
P602	DVTHPPAGDGK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P602	DVTHPQPGEDS	1	Arabidopsis thaliana
P67	KPEKCPRRVNR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P67	NPEVISKTVNR	1	Arabidopsis thaliana
Q545	LGMATQCVQMK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Q545	LGIVSQCCQPR	1	Arabidopsis thaliana
Q548	ATQCVQMKNVQ	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Q548	VSQCCQPRQVN	1	Arabidopsis thaliana
Q558	QRTTPQTLSNL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Q558	NKLNKQYMENV	1	Arabidopsis thaliana
Q588	RPPVFQQPVIF	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Q588	IPLITDRPTII	1	Arabidopsis thaliana
Q589	PPVFQQPVIFL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Q589	PLITDRPTIIM	1	Arabidopsis thaliana
Q675	GVSEGQFQQVL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Q675	GVSEGQFSQVL	1	Arabidopsis thaliana
Q757	SHAGIQGTSRP	6	Homo sapiens, Arabidopsis thaliana, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R179	YTPVGRSFFTA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R179	YVSVGRSFFHT	1	Arabidopsis thaliana
R277	CGQMKRKYRVC	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R277	WNGTKSA-KIS	1	Arabidopsis thaliana
R280	MKRKYRVCNVT	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R280	TKSA-KISGIS	1	Arabidopsis thaliana
R315	QYFKDRHKLVL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R315	QYFAEKYNYRV	1	Arabidopsis thaliana
R351	IVAGQRCIKKL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R351	IDEGQRYTKRL	1	Arabidopsis thaliana
R375	RSAPDRQEEIS	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R375	QRPPDRENSIK	1	Arabidopsis thaliana
R438	GVWDMRNKQFH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R438	GQWNMIDKKMV	1	Arabidopsis thaliana
R475	FTEQLRKISRD	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R475	FCKQLIGMCVS	1	Arabidopsis thaliana
R479	LRKISRDAGMP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R479	LIGMCVSKGME	1	Arabidopsis thaliana
R635	RVQQHRQEIIQ	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R635	SAQAHREEIIQ	1	Arabidopsis thaliana
R68	PEKCPRRVNRE	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R68	PEVISKTVNRN	1	Arabidopsis thaliana
R69	EKCPRRVNREI	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R69	EVISKTVNRNV	1	Arabidopsis thaliana
R710	IVVQKRHHTRL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R710	VIVQKRHHTRL	1	Arabidopsis thaliana
R714	KRHHTRLFCTD	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R714	KRHHTRLFPEQ	1	Arabidopsis thaliana
R761	IQGTSRPSHYH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R761	IQGTSRPAHYH	1	Arabidopsis thaliana
R792	CHTYVRCTRSV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R792	CYTYARCTKSV	1	Arabidopsis thaliana
R795	YVRCTRSVSIP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R795	YARCTKSVSIV	1	Arabidopsis thaliana
R812	HLVAFRARYHL	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R812	HLAAFRARYYM	1	Arabidopsis thaliana
R97	PVFDGRKNLYT	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R97	PAYDGRKSLYT	1	Arabidopsis thaliana
S220	LNIDVSATAFY	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S220	LNIDVSARSFY	1	Arabidopsis thaliana
S362	TDNQTSTMIRA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S362	NEKQVTALLKA	1	Arabidopsis thaliana
S561	TPQTLSNLCLK	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
S561	NKQYMENVALK	1	Arabidopsis thaliana
S561	TPQTLSNLWLK	1	Bos taurus
S672	YRDGVSEGQFQ	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S672	YRDGVSEGQFS	1	Arabidopsis thaliana
S760	GIQGTSRPSHY	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S760	GIQGTSRPAHY	1	Arabidopsis thaliana
S798	CTRSVSIPAPA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S798	CTKSVSIVPPA	1	Arabidopsis thaliana
T222	IDVSATAFYKA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T222	IDVSARSFYEP	1	Arabidopsis thaliana
T337	QEQKHTYLPLE	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T337	SDTRPVYLPME	1	Arabidopsis thaliana
T361	LTDNQTSTMIR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T361	LNEKQVTALLK	1	Arabidopsis thaliana
T368	TMIRATARSAP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T368	ALLKATCQRPP	1	Arabidopsis thaliana
T526	ILPGKTPVYAE	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T526	ILPDVTGSYGK	1	Arabidopsis thaliana
T544	VLGMATQCVQM	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T544	ELGIVSQCCQP	1	Arabidopsis thaliana
T556	NVQRTTPQTLS	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T556	QVNKLNKQYME	1	Arabidopsis thaliana
T559	RTTPQTLSNLC	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
T559	KLNKQYMENVA	1	Arabidopsis thaliana
T559	RTTPQTLSNLW	1	Bos taurus
T599	LGADVTHPPAG	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T599	MGADVTHPQPG	1	Arabidopsis thaliana
T759	AGIQGTSRPSH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T759	AGIQGTSRPAH	1	Arabidopsis thaliana
V177	MRYTPVGRSFF	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V177	NDYVSVGRSFF	1	Arabidopsis thaliana
V308	TVECTVAQYFK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V308	--EKTVVQYFA	1	Arabidopsis thaliana
V547	MATQCVQMKNV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V547	IVSQCCQPRQV	1	Arabidopsis thaliana
V591	VFQQPVIFLGA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V591	ITDRPTIIMGA	1	Arabidopsis thaliana
V598	FLGADVTHPPA	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V598	IMGADVTHPQP	1	Arabidopsis thaliana
V70	KCPRRVNREIV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V70	VISKTVNRNVM	1	Arabidopsis thaliana
Y279	QMKRKYRVCNV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y279	GTKSA-KISGI	1	Arabidopsis thaliana
Y311	CTVAQYFKDRH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y311	KTVVQYFAEKY	1	Arabidopsis thaliana
Y338	EQKHTYLPLEV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y338	DTRPVYLPMEL	1	Arabidopsis thaliana
Y529	GKTPVYAEVKR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y529	DVTGSYGKIKR	1	Arabidopsis thaliana
Y654	LLIQFYKSTRF	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y654	HFIAFRRATGQ	1	Arabidopsis thaliana
Y698	KLEKDYQPGIT	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
Y698	SLQENYVPRVT	1	Arabidopsis thaliana
Y698	KLEKEYQPGIT	1	Rattus norvegicus
Y790	QLCHTYVRCTR	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y790	NLCYTYARCTK	1	Arabidopsis thaliana
Y804	IPAPAYYAHLV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y804	IVPPAYYAHLA	1	Arabidopsis thaliana
Y815	AFRARYHLVDK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y815	AFRARYYMESE	1	Arabidopsis thaliana