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mutLBSgeneDB |
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| Gene summary for SULT1B1 |
 Gene summary |
| Basic gene Info. | Gene symbol | SULT1B1 |
| Gene name | sulfotransferase family, cytosolic, 1B, member 1 | |
| Synonyms | ST1B1|ST1B2|SULT1B2 | |
| Cytomap | UCSC genome browser: 4q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014465.3, | |
| Description | sulfotransferase 1B1sulfotransferase 1B2sulfotransferase family cytosolic 1B member 1thyroid hormone sulfotransferase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608436 | |
| HGNC : HGNC | ||
| HPRD : 07088 | ||
| Protein | UniProt: O43704 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SULT1B1 | |
| BioGPS: 27284 | ||
| Pathway | NCI Pathway Interaction Database: SULT1B1 | |
| KEGG: SULT1B1 | ||
| REACTOME: SULT1B1 | ||
| Pathway Commons: SULT1B1 | ||
| Context | iHOP: SULT1B1 | |
| ligand binding site mutation search in PubMed: SULT1B1 | ||
| UCL Cancer Institute: SULT1B1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006805 | xenobiotic metabolic process | 20056724 | GO:0009812 | flavonoid metabolic process | 20056724 | GO:0018958 | phenol-containing compound metabolic process | 9463486 | GO:0042403 | thyroid hormone metabolic process | 9443824 | GO:0051923 | sulfation | 20056724 |
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| Ligand binding site mutations for SULT1B1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R131 | A133V | BRCA | 1 | G260 | G260W | COAD | 1 | T228 | H227Y | GBM | 1 | S139 | Y140F | KIRC | 1 | L244 | P245T | LUAD | 1 | K48 | P47T | LUSC | 1 | Y170 | S172F | SKCM | 1 | R131 | R131H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SULT1B1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L244 | P245T | -1.2727236 | R131 | R131H | -1.2491028 | K48 | P47T | -0.94646549 | S139 | Y140F | -0.78565065 | Y170 | S172F | -0.77955506 | R131 | A133V | -0.50855297 | G260 | G260W | -0.17799295 | T228 | H227Y | -0.077130897 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SULT1B1 from PDB |
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| Differential gene expression and gene-gene network for SULT1B1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SULT1B1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SULT1B1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01812 | Adenosine-3'-5'-Diphosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SULT1B1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 2z5f | A | K48 R131 S139 T228 G260 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 2z5f | B | K48 R131 S139 T228 G260 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3ckl | A | K48 R131 S139 T228 G260 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3ckl | B | K48 R131 S139 T228 G260 | STL | RESVERATROL | 3ckl | A | Y170 L244 | STL | RESVERATROL | 3ckl | B | Y170 L244 |
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| Conservation information for LBS of SULT1B1 |
| Multiple alignments for O43704 in multiple species |
| LBS | AA sequence | # species | Species | F143 | VSYYHFDLMNN | 3 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris | F143 | VSYYHFDLMNK | 1 | Gallus gallus | F143 | VSYYHFDLMNS | 1 | Mus musculus | F143 | VSFYHFDLMNN | 1 | Bos taurus | F230 | IHHTSFEVMKD | 1 | Homo sapiens | F230 | AHHTSFEAMRD | 1 | Gallus gallus | F230 | VHHTSFEMMKE | 1 | Mus musculus | F230 | VHHTSFEVMKD | 1 | Rattus norvegicus | F230 | IYHTSFEMMKD | 1 | Bos taurus | F230 | IHHTSFEMMKD | 1 | Canis lupus familiaris | F24 | PMTCAFASNWE | 1 | Homo sapiens | F24 | PMVSAFAQNWE | 1 | Gallus gallus | F24 | PMIYAFALNWE | 1 | Mus musculus | F24 | PMVYAFALGWE | 1 | Rattus norvegicus | F24 | PITYAFANNWE | 1 | Bos taurus | F24 | PIIYTFANNWE | 1 | Canis lupus familiaris | F256 | HSKSSFMRKGI | 2 | Bos taurus, Canis lupus familiaris | F256 | HSKSPFMRKGT | 1 | Homo sapiens | F256 | HGISPFMRKGI | 1 | Gallus gallus | F256 | HSKSPFMRKGI | 1 | Mus musculus | F256 | HSKSPFMRKGV | 1 | Rattus norvegicus | G260 | SFMRKGIAGDW | 2 | Bos taurus, Canis lupus familiaris | G260 | PFMRKGTAGDW | 1 | Homo sapiens | G260 | PFMRKGITGDW | 1 | Gallus gallus | G260 | PFMRKGIVGDW | 1 | Mus musculus | G260 | PFMRKGVVGDW | 1 | Rattus norvegicus | G50 | TYPKSGTTWVS | 2 | Homo sapiens, Canis lupus familiaris | G50 | TYPKSGTTWLS | 2 | Mus musculus, Rattus norvegicus | G50 | TFPKSGTTWIS | 1 | Gallus gallus | G50 | TYPKSGTTWIS | 1 | Bos taurus | H109 | RIIKTHLPIDL | 2 | Mus musculus, Rattus norvegicus | H109 | RIVKTHLPTDL | 1 | Homo sapiens | H109 | RIIKTHIPADI | 1 | Gallus gallus | H109 | RVVKTHLPIDL | 1 | Bos taurus | H109 | RLVKTHLPIAL | 1 | Canis lupus familiaris | K259 | SSFMRKGIAGD | 2 | Bos taurus, Canis lupus familiaris | K259 | SPFMRKGTAGD | 1 | Homo sapiens | K259 | SPFMRKGITGD | 1 | Gallus gallus | K259 | SPFMRKGIVGD | 1 | Mus musculus | K259 | SPFMRKGVVGD | 1 | Rattus norvegicus | K48 | IATYPKSGTTW | 2 | Homo sapiens, Canis lupus familiaris | K48 | VATFPKSGTTW | 1 | Gallus gallus | K48 | ITTYPKSGTTW | 1 | Mus musculus | K48 | IPTYPKSGTTW | 1 | Rattus norvegicus | K48 | IVTYPKSGTTW | 1 | Bos taurus | L149 | DLMNNLQPFPG | 1 | Homo sapiens | L149 | DLMNKLHPHPG | 1 | Gallus gallus | L149 | DLMNSINPLPG | 1 | Mus musculus | L149 | DLMNNIQPLPG | 1 | Rattus norvegicus | L149 | DLMNNLQPLPG | 1 | Bos taurus | L149 | DLMNNLEPAPG | 1 | Canis lupus familiaris | L244 | VNYTHLPTTVM | 1 | Homo sapiens | L244 | TNYSVVPSQLM | 1 | Gallus gallus | L244 | VNYTHLPTAMM | 1 | Mus musculus | L244 | VNYTHLPTEIM | 1 | Rattus norvegicus | L244 | VNYTHLPSEVM | 1 | Bos taurus | L244 | VNYTHLPSTVM | 1 | Canis lupus familiaris | M233 | TSFEVMKDNPL | 2 | Homo sapiens, Rattus norvegicus | M233 | TSFEMMKDNPL | 2 | Bos taurus, Canis lupus familiaris | M233 | TSFEAMRDNPS | 1 | Gallus gallus | M233 | TSFEMMKENPL | 1 | Mus musculus | M257 | SKSSFMRKGIA | 2 | Bos taurus, Canis lupus familiaris | M257 | SKSPFMRKGTA | 1 | Homo sapiens | M257 | GISPFMRKGIT | 1 | Gallus gallus | M257 | SKSPFMRKGIV | 1 | Mus musculus | M257 | SKSPFMRKGVV | 1 | Rattus norvegicus | M81 | TEKVPMLEMTL | 1 | Homo sapiens | M81 | VNRVPMLEFAA | 1 | Gallus gallus | M81 | TSKVPMLELSV | 1 | Mus musculus | M81 | TSKVPMLEQNV | 1 | Rattus norvegicus | M81 | TAKVPMLELAL | 1 | Bos taurus | M81 | TVKVPMLEMAV | 1 | Canis lupus familiaris | N147 | HFDLMNNLQPF | 1 | Homo sapiens | N147 | HFDLMNKLHPH | 1 | Gallus gallus | N147 | HFDLMNSINPL | 1 | Mus musculus | N147 | HFDLMNNIQPL | 1 | Rattus norvegicus | N147 | HFDLMNNLQPL | 1 | Bos taurus | N147 | HFDLMNNLEPA | 1 | Canis lupus familiaris | Q150 | LMNNLQPFPGT | 1 | Homo sapiens | Q150 | LMNKLHPHPGT | 1 | Gallus gallus | Q150 | LMNSINPLPGT | 1 | Mus musculus | Q150 | LMNNIQPLPGT | 1 | Rattus norvegicus | Q150 | LMNNLQPLPGT | 1 | Bos taurus | Q150 | LMNNLEPAPGP | 1 | Canis lupus familiaris | R131 | MIYLARNAKDV | 2 | Homo sapiens, Canis lupus familiaris | R131 | MIYLARNGKDV | 2 | Mus musculus, Rattus norvegicus | R131 | MIYVGRNAKDV | 1 | Gallus gallus | R131 | IIYLARNAKDV | 1 | Bos taurus | R258 | KSSFMRKGIAG | 2 | Bos taurus, Canis lupus familiaris | R258 | KSPFMRKGTAG | 1 | Homo sapiens | R258 | ISPFMRKGITG | 1 | Gallus gallus | R258 | KSPFMRKGIVG | 1 | Mus musculus | R258 | KSPFMRKGVVG | 1 | Rattus norvegicus | S139 | KDVAVSYYHFD | 4 | Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris | S139 | KDVSVSYYHFD | 1 | Homo sapiens | S139 | KDVAVSFYHFD | 1 | Bos taurus | S229 | IIHHTSFEVMK | 1 | Homo sapiens | S229 | IAHHTSFEAMR | 1 | Gallus gallus | S229 | IVHHTSFEMMK | 1 | Mus musculus | S229 | IVHHTSFEVMK | 1 | Rattus norvegicus | S229 | IIYHTSFEMMK | 1 | Bos taurus | S229 | IIHHTSFEMMK | 1 | Canis lupus familiaris | S49 | ATYPKSGTTWV | 2 | Homo sapiens, Canis lupus familiaris | S49 | ATFPKSGTTWI | 1 | Gallus gallus | S49 | TTYPKSGTTWL | 1 | Mus musculus | S49 | PTYPKSGTTWL | 1 | Rattus norvegicus | S49 | VTYPKSGTTWI | 1 | Bos taurus | T21 | HGYPMTCAFAS | 1 | Homo sapiens | T21 | HAIPMVSAFAQ | 1 | Gallus gallus | T21 | HGYPMIYAFAL | 1 | Mus musculus | T21 | HGYPMVYAFAL | 1 | Rattus norvegicus | T21 | HGCPITYAFAN | 1 | Bos taurus | T21 | HGYPIIYTFAN | 1 | Canis lupus familiaris | T228 | RIIHHTSFEVM | 1 | Homo sapiens | T228 | AIAHHTSFEAM | 1 | Gallus gallus | T228 | RIVHHTSFEMM | 1 | Mus musculus | T228 | RIVHHTSFEVM | 1 | Rattus norvegicus | T228 | KIIYHTSFEMM | 1 | Bos taurus | T228 | KIIHHTSFEMM | 1 | Canis lupus familiaris | T51 | YPKSGTTWVSE | 2 | Homo sapiens, Canis lupus familiaris | T51 | YPKSGTTWLSE | 2 | Mus musculus, Rattus norvegicus | T51 | FPKSGTTWISE | 1 | Gallus gallus | T51 | YPKSGTTWISE | 1 | Bos taurus | T52 | PKSGTTWVSEI | 2 | Homo sapiens, Canis lupus familiaris | T52 | PKSGTTWISEI | 2 | Gallus gallus, Bos taurus | T52 | PKSGTTWLSEI | 2 | Mus musculus, Rattus norvegicus | V248 | HLPTTVMDHSK | 1 | Homo sapiens | V248 | VVPSQLMDHGI | 1 | Gallus gallus | V248 | HLPTAMMDHSK | 1 | Mus musculus | V248 | HLPTEIMDHSK | 1 | Rattus norvegicus | V248 | HLPSEVMDHSK | 1 | Bos taurus | V248 | HLPSTVMDHSK | 1 | Canis lupus familiaris | W53 | KSGTTWISEIV | 2 | Gallus gallus, Bos taurus | W53 | KSGTTWLSEIV | 2 | Mus musculus, Rattus norvegicus | W53 | KSGTTWVSEII | 1 | Homo sapiens | W53 | KSGTTWVSEIV | 1 | Canis lupus familiaris | Y170 | AGNVAYGSWFD | 2 | Mus musculus, Rattus norvegicus | Y170 | TGNVAYGSWFN | 2 | Bos taurus, Canis lupus familiaris | Y170 | TGKVAYGSWFT | 1 | Homo sapiens | Y170 | AGKVAYGSWFD | 1 | Gallus gallus | Y194 | ILFLYYEDMKE | 2 | Homo sapiens, Canis lupus familiaris | Y194 | ILYLFYEDMKE | 1 | Gallus gallus | Y194 | LLYLYYEELKQ | 1 | Mus musculus | Y194 | ILFLYYEDLKK | 1 | Rattus norvegicus | Y194 | ILFLFYEDMKE | 1 | Bos taurus |
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