mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DIMT1
Gene summary
Basic gene Info.Gene symbolDIMT1
Gene nameDIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
SynonymsDIM1|DIMT1L|HSA9761|HUSSY5
CytomapUCSC genome browser: 5q12.1
Type of geneprotein-coding
RefGenesNM_014473.2,
Description18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase18S rRNA dimethylaseS-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferasedimethyladenosine transferaseprobable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltrans
Modification date20141207
dbXrefs MIM : 612499
HGNC : HGNC
HPRD : 13676
ProteinUniProt: Q9UNQ2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DIMT1
BioGPS: 27292
PathwayNCI Pathway Interaction Database: DIMT1
KEGG: DIMT1
REACTOME: DIMT1
Pathway Commons: DIMT1
ContextiHOP: DIMT1
ligand binding site mutation search in PubMed: DIMT1
UCL Cancer Institute: DIMT1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for DIMT1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E85E85GCOAD3
G64G64RCOAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DIMT1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E85E85G-0.98772693
G64G64R-0.69356239
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DIMT1 from PDB
PDB IDPDB titlePDB structure
1ZQ9Crystal structure of human Dimethyladenosine transferase

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Differential gene expression and gene-gene network for DIMT1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DIMT1 and the right PPI network was created from samples without mutations in the LBS of DIMT1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DIMT1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DIMT1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DIMT1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SAMS-ADENOSYL-L-METHIONINE1zq9AG64 E85
SAMS-ADENOSYL-L-METHIONINE1zq9BG64 E85


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Conservation information for LBS of DIMT1
Multiple alignments for Q9UNQ2 in multiple species
LBSAA sequence# speciesSpecies
C84KKVVACELDPR2Homo sapiens, Mus musculus
C84RKVVAVEFDPR2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C84KEVIAVELDSR1Arabidopsis thaliana
C84RKVIAVEMDPR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C84KNVVAVEMDPR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C84KTVIACEIDPR1Caenorhabditis elegans
C84KKVIACEIDTR1Drosophila melanogaster
C84KKVIACELDPR1Bos taurus
D113EIMLGDFMKTE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D113QVLVGDVLKTD1Homo sapiens
D113KVIQGDVLKTE1Arabidopsis thaliana
D113QVVLGDVIKTD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D113EILLGDFMKTE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D113QVNGGDVMKME1Caenorhabditis elegans
D113QVLIGDFLKAE1Drosophila melanogaster
D113QVLVGDVLKSD1Mus musculus
D113QVMVGDVLKAD1Bos taurus
E85KVVACELDPRL2Homo sapiens, Mus musculus
E85KVVAVEFDPRM2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E85EVIAVELDSRM1Arabidopsis thaliana
E85KVIAVEMDPRM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E85NVVAVEMDPRM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E85TVIACEIDPRM1Caenorhabditis elegans
E85KVIACEIDTRL1Drosophila melanogaster
E85KVIACELDPRL1Bos taurus
F196VGKNNFRPPPK6Homo sapiens, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Drosophila melanogaster, Mus musculus, Bos taurus
F196VGKNNFRPPPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F196VGKNNFRPPPQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F196VGRNNFRPPPQ1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F196VKRTEFRPPPK1Caenorhabditis elegans
G112LEIMLGDFMKT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G112LQVLVGDVLKT1Homo sapiens
G112LKVIQGDVLKT1Arabidopsis thaliana
G112LQVVLGDVIKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G112LEILLGDFMKT1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G112LQVNGGDVMKM1Caenorhabditis elegans
G112LQVLIGDFLKA1Drosophila melanogaster
G112LQVLVGDVLKS1Mus musculus
G112LQVMVGDVLKA1Bos taurus
G64VVLEVGPGTGN4Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Bos taurus
G64TVLEVGPGTGN2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
G64VILEIGPGTGN1Arabidopsis thaliana
G64IVLEIGPGTGN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G64IVLEVGPGTGN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G64VVLEIGPGTGN1Drosophila melanogaster
G66LEVGPGTGNLT4Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Caenorhabditis elegans
G66LEVGPGTGNMT3Homo sapiens, Mus musculus, Bos taurus
G66LEIGPGTGNLT2Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G66LEIGPGTGNMT1Drosophila melanogaster
H37TGIGQHILKNP3Homo sapiens, Mus musculus, Bos taurus
H37TDLGQHILKNP3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H37KDFGQHILKNP2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
H37KSKGQHILKNP1Arabidopsis thaliana
H37TDKGQHILKNP1Caenorhabditis elegans
I133NLPYQISSPFV4Homo sapiens, Caenorhabditis elegans, Mus musculus, Bos taurus
I133NTPYQISSPLV4Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 /
I133NIPYQISSPLT1Arabidopsis thaliana
I133NVPYQISSPLI1Drosophila melanogaster
I38GIGQHILKNPL3Homo sapiens, Mus musculus, Bos taurus
I38DLGQHILKNPL3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I38DFGQHILKNPL2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
I38SKGQHILKNPL1Arabidopsis thaliana
I38DKGQHILKNPG1Caenorhabditis elegans
L129ICISNTPYQIS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L129ACVANLPYQIS2Mus musculus, Bos taurus
L129TCVANLPYQIS1Homo sapiens
L129ICVANIPYQIS1Arabidopsis thaliana
L129VCVSNTPYQIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L129VCISNTPYQIS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L129VCVANLPYQIS1Caenorhabditis elegans
L129LCIANVPYQIS1Drosophila melanogaster
L86VVACELDPRLV2Homo sapiens, Mus musculus
L86VVAVEFDPRMA2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L86VIAVELDSRMV1Arabidopsis thaliana
L86VIAVEMDPRMA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L86VVAVEMDPRMA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L86VIACEIDPRMI1Caenorhabditis elegans
L86VIACEIDTRLA1Drosophila melanogaster
L86VIACELDPRLV1Bos taurus
L90ELDPRLVAELH3Homo sapiens, Mus musculus, Bos taurus
L90EFDPRMAAELT2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L90ELDSRMVLELQ1Arabidopsis thaliana
L90EMDPRMAAEIT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L90EMDPRMAAELT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L90EIDPRMIAEVK1Caenorhabditis elegans
L90EIDTRLAAELQ1Drosophila melanogaster
N128DICISNTPYQI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N128DACVANLPYQI2Mus musculus, Bos taurus
N128DTCVANLPYQI1Homo sapiens
N128DICVANIPYQI1Arabidopsis thaliana
N128DVCVSNTPYQI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N128DVCISNTPYQI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N128DVCVANLPYQI1Caenorhabditis elegans
N128DLCIANVPYQI1Drosophila melanogaster
P130CVANLPYQISS4Homo sapiens, Caenorhabditis elegans, Mus musculus, Bos taurus
P130CISNTPYQISS3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P130CVANIPYQISS1Arabidopsis thaliana
P130CVSNTPYQISS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P130CIANVPYQISS1Drosophila melanogaster
Q36NTGIGQHILKN3Homo sapiens, Mus musculus, Bos taurus
Q36NTDLGQHILKN3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q36NKDFGQHILKN2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
Q36HKSKGQHILKN1Arabidopsis thaliana
Q36NTDKGQHILKN1Caenorhabditis elegans
S204PPKVESSVVRI4Homo sapiens, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Mus musculus, Bos taurus
S204PPKVDSSVVRI1Arabidopsis thaliana
S204PPLVESSVVRI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S204PPQVESSVVRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S204PPQVESSVVRI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S204PPKVDSAVVRI1Caenorhabditis elegans
S204PPKVESSVVRL1Drosophila melanogaster
V114IMLGDFMKTEL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V114VLVGDVLKTDL1Homo sapiens
V114VIQGDVLKTEL1Arabidopsis thaliana
V114VVLGDVIKTDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V114ILLGDFMKTEL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V114VNGGDVMKMEW1Caenorhabditis elegans
V114VLIGDFLKAEL1Drosophila melanogaster
V114VLVGDVLKSDL1Mus musculus
V114VMVGDVLKADL1Bos taurus


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