|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for MAT2B |
 Gene summary |
| Basic gene Info. | Gene symbol | MAT2B |
| Gene name | methionine adenosyltransferase II, beta | |
| Synonyms | MAT-II|MATIIbeta|Nbla02999|SDR23E1|TGR | |
| Cytomap | UCSC genome browser: 5q34-q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_013283.4, NM_182796.2, | |
| Description | MAT II betabeta regulatory subunit of methionine adenosyltransferasedTDP-4-keto-6-deoxy-D-glucose 4-reductasemethionine adenosyltransferase 2 subunit betaputative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseputative protein product of Nbla02999short ch | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605527 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000038274 | ||
| HPRD : 05701 | ||
| Vega : OTTHUMG00000130379 | ||
| Protein | UniProt: Q9NZL9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAT2B | |
| BioGPS: 27430 | ||
| Pathway | NCI Pathway Interaction Database: MAT2B | |
| KEGG: MAT2B | ||
| REACTOME: MAT2B | ||
| Pathway Commons: MAT2B | ||
| Context | iHOP: MAT2B | |
| ligand binding site mutation search in PubMed: MAT2B | ||
| UCL Cancer Institute: MAT2B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006556 | S-adenosylmethionine biosynthetic process | 10644686 | GO:0050790 | regulation of catalytic activity | 10644686 |
| Top |
| Ligand binding site mutations for MAT2B |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A196 | A196V | COAD | 1 | A293 | R291I | COAD | 1 | R61 | R61I | LUAD | 1 | F220 | P221R | SKCM | 1 | R329 | T331M | UCEC | 1 | D84 | H83N | UCEC | 1 | A293 | R291I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for MAT2B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D84 | H83N | -1.2162395 | F220 | P221R | -1.1275457 | A293 | R291I | -0.66595251 | A196 | A196V | -0.60152564 | R329 | T331M | -0.53447228 | R61 | R61I | -0.51189085 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MAT2B from PDB |
| Top |
| Differential gene expression and gene-gene network for MAT2B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for MAT2B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for MAT2B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of MAT2B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | STL | RESVERATROL | 2ydx | A | A196 | STL | RESVERATROL | 2ydx | B | A196 | STL | RESVERATROL | 2ydx | C | A196 | STL | RESVERATROL | 2ydx | D | A196 | STL | RESVERATROL | 2ydx | E | A196 | STL | RESVERATROL | 2ydx | A | D84 | STL | RESVERATROL | 2ydx | C | D84 | STL | RESVERATROL | 2ydx | D | D84 | STL | RESVERATROL | 2ydx | E | D84 | CA | CALCIUM(2+) | 2ydx | A | F220 A293 | STL | RESVERATROL | 2ydx | A | R329 | STL | RESVERATROL | 2ydx | B | R329 | STL | RESVERATROL | 2ydx | C | R329 | STL | RESVERATROL | 2ydx | D | R329 | STL | RESVERATROL | 2ydx | E | R329 | NAP | NADP ZWITTERION | 2ydx | A | R61 | NAP | NADP ZWITTERION | 2ydx | B | R61 | NAP | NADP ZWITTERION | 2ydx | C | R61 | NAP | NADP ZWITTERION | 2ydx | D | R61 | TXP | 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE | 2ydx | E | R61 |
| Top |
| Conservation information for LBS of MAT2B |
| Multiple alignments for Q9NZL9 in multiple species |
| LBS | AA sequence | # species | Species | A196 | KLEESAVTVMF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A196 | KLSESAVTILF | 1 | Xenopus tropicalis | A196 | RLEESAVTIMF | 1 | Bos taurus | A293 | QRPRNAQLDCS | 2 | Homo sapiens, Bos taurus | A293 | QRPKNAQLDCS | 2 | Mus musculus, Rattus norvegicus | A293 | PRPWNPQLDCS | 1 | Xenopus tropicalis | A77 | LLDSNAVHHII | 2 | Homo sapiens, Bos taurus | A77 | LLDSEAVHHLI | 2 | Mus musculus, Rattus norvegicus | A77 | LLDAAAVKALI | 1 | Xenopus tropicalis | A94 | VIVHCAAERRP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A94 | VIIHCAAERRP | 1 | Xenopus tropicalis | A95 | IVHCAAERRPD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A95 | IIHCAAERRPD | 1 | Xenopus tropicalis | C93 | HVIVHCAAERR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | C93 | HVIIHCAAERR | 1 | Xenopus tropicalis | D137 | IYISSDYVFDG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D137 | IYVSSDYVFDG | 1 | Xenopus tropicalis | D74 | QVNLLDSNAVH | 2 | Homo sapiens, Bos taurus | D74 | QVNLLDSEAVH | 2 | Mus musculus, Rattus norvegicus | D74 | YLNLLDAAAVK | 1 | Xenopus tropicalis | D84 | HHLIHDFQPHV | 2 | Mus musculus, Rattus norvegicus | D84 | HHIIHDFQPHV | 1 | Homo sapiens | D84 | KALIQDFKPHV | 1 | Xenopus tropicalis | D84 | HHIIYDFQPHV | 1 | Bos taurus | E193 | EVEKLEESAVT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E193 | DVEKLSESAVT | 1 | Xenopus tropicalis | E193 | EVERLEESAVT | 1 | Bos taurus | E68 | ARPKFEQVNLL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E68 | ARPRFEYLNLL | 1 | Xenopus tropicalis | F220 | HWQQRFPTHVK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F220 | HWQQRFPTYVK | 1 | Xenopus tropicalis | F60 | AVGCGFRRARP | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F60 | VLGCGYSRARP | 1 | Xenopus tropicalis | F60 | TVGCGFRRARP | 1 | Mus musculus | G35 | RVLITGATGLL | 3 | Mus musculus, Rattus norvegicus, Bos taurus | G35 | RVLVTGATGLL | 1 | Homo sapiens | G35 | RALITGATGLL | 1 | Xenopus tropicalis | G38 | ITGATGLLGRA | 4 | Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | G38 | VTGATGLLGRA | 1 | Homo sapiens | H80 | SEAVHHLIHDF | 2 | Mus musculus, Rattus norvegicus | H80 | SNAVHHIIHDF | 1 | Homo sapiens | H80 | AAAVKALIQDF | 1 | Xenopus tropicalis | H80 | SNAVHHIIYDF | 1 | Bos taurus | I134 | AFLIYISSDYV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I134 | AFLIYVSSDYV | 1 | Xenopus tropicalis | I182 | AAVLRIPVLYG | 3 | Mus musculus, Rattus norvegicus, Bos taurus | I182 | AAVLRIPILYG | 1 | Homo sapiens | I182 | AAVLRVPVLYG | 1 | Xenopus tropicalis | I184 | VLRIPVLYGEV | 3 | Mus musculus, Rattus norvegicus, Bos taurus | I184 | VLRIPILYGEV | 1 | Homo sapiens | I184 | VLRVPVLYGDV | 1 | Xenopus tropicalis | K163 | LYGKTKLDGEK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K163 | LYGKTKLEGER | 1 | Xenopus tropicalis | K163 | LYGKTKLEGEK | 1 | Bos taurus | L112 | DAASQLNVDAS | 2 | Homo sapiens, Bos taurus | L112 | DAASQLNVGAS | 2 | Mus musculus, Rattus norvegicus | L112 | EFASLLNVVAS | 1 | Xenopus tropicalis | L185 | LRIPVLYGEVE | 3 | Mus musculus, Rattus norvegicus, Bos taurus | L185 | LRIPILYGEVE | 1 | Homo sapiens | L185 | LRVPVLYGDVE | 1 | Xenopus tropicalis | L39 | TGATGLLGRAV | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | L40 | GATGLLGRAVY | 4 | Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | L40 | GATGLLGRAVH | 1 | Homo sapiens | L72 | FEQVNLLDSNA | 2 | Homo sapiens, Bos taurus | L72 | FEQVNLLDSEA | 2 | Mus musculus, Rattus norvegicus | L72 | FEYLNLLDAAA | 1 | Xenopus tropicalis | N71 | KFEQVNLLDSN | 2 | Homo sapiens, Bos taurus | N71 | KFEQVNLLDSE | 2 | Mus musculus, Rattus norvegicus | N71 | RFEYLNLLDAA | 1 | Xenopus tropicalis | N76 | NLLDSNAVHHI | 2 | Homo sapiens, Bos taurus | N76 | NLLDSEAVHHL | 2 | Mus musculus, Rattus norvegicus | N76 | NLLDAAAVKAL | 1 | Xenopus tropicalis | P183 | AVLRIPVLYGE | 3 | Mus musculus, Rattus norvegicus, Bos taurus | P183 | AVLRIPILYGE | 1 | Homo sapiens | P183 | AVLRVPVLYGD | 1 | Xenopus tropicalis | P99 | AAERRPDVVEN | 2 | Homo sapiens, Bos taurus | P99 | AAERRPDVVES | 2 | Mus musculus, Rattus norvegicus | P99 | AAERRPDIVES | 1 | Xenopus tropicalis | R219 | DHWQQRFPTHV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R219 | DHWQQRFPTYV | 1 | Xenopus tropicalis | R329 | IDKRWRQTVFH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R329 | VDKRWRQTVFH | 1 | Xenopus tropicalis | R61 | VGCGFRRARPK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R61 | LGCGYSRARPR | 1 | Xenopus tropicalis | R62 | GCGFRRARPKF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R62 | GCGYSRARPRF | 1 | Xenopus tropicalis | R97 | HCAAERRPDVV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R97 | HCAAERRPDIV | 1 | Xenopus tropicalis | R98 | CAAERRPDVVE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R98 | CAAERRPDIVE | 1 | Xenopus tropicalis | S135 | FLIYISSDYVF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S135 | FLIYVSSDYVF | 1 | Xenopus tropicalis | S136 | LIYISSDYVFD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S136 | LIYVSSDYVFD | 1 | Xenopus tropicalis | S195 | EKLEESAVTVM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S195 | EKLSESAVTIL | 1 | Xenopus tropicalis | S195 | ERLEESAVTIM | 1 | Bos taurus | T37 | LITGATGLLGR | 4 | Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | T37 | LVTGATGLLGR | 1 | Homo sapiens | V70 | PKFEQVNLLDS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V70 | PRFEYLNLLDA | 1 | Xenopus tropicalis | W328 | LIDKRWRQTVF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | W328 | LVDKRWRQTVF | 1 | Xenopus tropicalis | Y138 | YISSDYVFDGT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | Y138 | YVSSDYVFDGT | 1 | Xenopus tropicalis | Y159 | NPLNLYGKTKL | 2 | Xenopus tropicalis, Bos taurus | Y159 | SPLNLYGKTKL | 2 | Mus musculus, Rattus norvegicus | Y159 | APLNLYGKTKL | 1 | Homo sapiens |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |