mutLBSgeneDB |
Gene summary for GLS |
Gene summary |
Basic gene Info. | Gene symbol | GLS |
Gene name | glutaminase | |
Synonyms | AAD20|GAC|GAM|GLS1|KGA | |
Cytomap | UCSC genome browser: 2q32-q34 | |
Type of gene | protein-coding | |
RefGenes | NM_001256310.1, NM_014905.4, | |
Description | K-glutaminaseL-glutamine amidohydrolaseglutaminase Cglutaminase kidney isoform, mitochondrialglutaminase, phosphate-activated | |
Modification date | 20141222 | |
dbXrefs | MIM : 138280 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115419 | ||
HPRD : 00700 | ||
Vega : OTTHUMG00000132701 | ||
Protein | UniProt: O94925 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GLS | |
BioGPS: 2744 | ||
Pathway | NCI Pathway Interaction Database: GLS | |
KEGG: GLS | ||
REACTOME: GLS | ||
Pathway Commons: GLS | ||
Context | iHOP: GLS | |
ligand binding site mutation search in PubMed: GLS | ||
UCL Cancer Institute: GLS | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006537 | glutamate biosynthetic process | 16899818 | GO:0006543 | glutamine catabolic process | 22049910 | GO:0051289 | protein homotetramerization | 22049910 |
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Ligand binding site mutations for GLS |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Y466 | M465L | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GLS |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y466 | M465L | -0.92829792 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for GLS from PDB |
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Differential gene expression and gene-gene network for GLS |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for GLS |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0000786 | Abortion, Spontaneous | 1 | Biomarker |
umls:C0029408 | Osteoarthritis | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GLS |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Nutraceutical | DB00142 | L-Glutamic Acid | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of GLS go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GLU | L-GLUTAMIC ACID | 3czd | A | Y466 | GLU | L-GLUTAMIC ACID | 3unw | A | Y466 | GLU | L-GLUTAMIC ACID | 3unw | B | Y466 | GLU | L-GLUTAMIC ACID | 3unw | C | Y466 | GLU | L-GLUTAMIC ACID | 3unw | D | Y466 | GLN | L-GLUTAMINE | 3vp0 | A | Y466 | GLU | L-GLUTAMIC ACID | 3vp1 | A | Y466 | ONL | 5-OXO-L-NORLEUCINE | 4o7d | A | Y466 |
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Conservation information for LBS of GLS |
Multiple alignments for O94925 in multiple species |
LBS | AA sequence | # species | Species | C418 | FYFQLCSIEVT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C418 | LYFQICSIETN | 1 | Caenorhabditis elegans | C418 | FYFQLCSVEVT | 1 | Caenorhabditis elegans | D327 | FLNEDDKPHNP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D327 | SLDHNKKPHNP | 1 | Caenorhabditis elegans | D327 | CLDSTNKPHNP | 1 | Caenorhabditis elegans | E325 | KLFLNEDDKPH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E325 | DISLDHNKKPH | 1 | Caenorhabditis elegans | E325 | EICLDSTNKPH | 1 | Caenorhabditis elegans | E381 | ATFQSERESGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E381 | SVFLSERETAD | 1 | Caenorhabditis elegans | E381 | ATFLSERATAD | 1 | Caenorhabditis elegans | F318 | PSGLRFNKLFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F318 | PSGRLFNDISL | 1 | Caenorhabditis elegans | F318 | PSGRLFNEICL | 1 | Caenorhabditis elegans | F322 | RFNKLFLNEDD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F322 | LFNDISLDHNK | 1 | Caenorhabditis elegans | F322 | LFNEICLDSTN | 1 | Caenorhabditis elegans | G483 | LPAKSGVAGGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G483 | LPAKSGVSGDM | 1 | Caenorhabditis elegans | G483 | LPAKSGVSGAM | 1 | Caenorhabditis elegans | K320 | GLRFNKLFLNE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K320 | GRLFNDISLDH | 1 | Caenorhabditis elegans | K320 | GRLFNEICLDS | 1 | Caenorhabditis elegans | L321 | LRFNKLFLNED | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L321 | RLFNDISLDHN | 1 | Caenorhabditis elegans | L321 | RLFNEICLDST | 1 | Caenorhabditis elegans | L323 | FNKLFLNEDDK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L323 | FNDISLDHNKK | 1 | Caenorhabditis elegans | L323 | FNEICLDSTNK | 1 | Caenorhabditis elegans | N324 | NKLFLNEDDKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N324 | NDISLDHNKKP | 1 | Caenorhabditis elegans | N324 | NEICLDSTNKP | 1 | Caenorhabditis elegans | N335 | HNPMVNAGAIV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N335 | HNPLINAGAIV | 1 | Caenorhabditis elegans | N335 | HNPMVNSGAIV | 1 | Caenorhabditis elegans | N388 | ESGDRNFAIGY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N388 | ETADRNYALSY | 1 | Caenorhabditis elegans | N388 | ATADRNYALSY | 1 | Caenorhabditis elegans | Q285 | VPFCLQSCVKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q285 | KPFCLQSVSKP | 1 | Caenorhabditis elegans | Q285 | HPFCVQSVSKA | 1 | Caenorhabditis elegans | R317 | EPSGLRFNKLF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R317 | EPSGRLFNDIS | 1 | Caenorhabditis elegans | R317 | EPSGRLFNEIC | 1 | Caenorhabditis elegans | S286 | PFCLQSCVKPL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S286 | PFCLQSVSKPF | 1 | Caenorhabditis elegans | S286 | PFCVQSVSKAF | 1 | Caenorhabditis elegans | V484 | PAKSGVAGGIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V484 | PAKSGVSGDMI | 1 | Caenorhabditis elegans | V484 | PAKSGVSGAMI | 1 | Caenorhabditis elegans | Y249 | GKVADYIPQLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y249 | GDLATYIPQLS | 1 | Caenorhabditis elegans | Y249 | GQVATYIPQLA | 1 | Caenorhabditis elegans | Y394 | FAIGYYLKEKK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y394 | YALSYYMREHK | 1 | Caenorhabditis elegans | Y394 | YALSYFMKENR | 1 | Caenorhabditis elegans | Y414 | GILDFYFQLCS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y414 | DTLDLYFQICS | 1 | Caenorhabditis elegans | Y414 | DALDFYFQLCS | 1 | Caenorhabditis elegans | Y466 | HSCGMYDFSGQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y466 | YSCGMYDWSGQ | 1 | Caenorhabditis elegans | Y466 | YSCGMYDASGQ | 1 | Caenorhabditis elegans |
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