mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for GLUL

Gene summary

Basic gene Info.	Gene symbol	GLUL
	Gene name	glutamate-ammonia ligase
	Synonyms	GLNS\|GS\|PIG43\|PIG59
	Cytomap	UCSC genome browser: 1q31
	Type of gene	protein-coding
	RefGenes	NM_001033044.2, NM_001033056.2,NM_002065.5,
	Description	cell proliferation-inducing protein 59glutamate decarboxylaseglutamate--ammonia ligaseglutamine synthaseglutamine synthetaseproliferation-inducing protein 43
	Modification date	20141207
dbXrefs	MIM : 138290
	HGNC : HGNC
	Ensembl : ENSG00000135821
	HPRD : 00701
	Vega : OTTHUMG00000037407
Protein	UniProt: P15104 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GLUL
	BioGPS: 2752
Pathway	NCI Pathway Interaction Database: GLUL
	KEGG: GLUL
	REACTOME: GLUL
	Pathway Commons: GLUL
Context	iHOP: GLUL
	ligand binding site mutation search in PubMed: GLUL
	UCL Cancer Institute: GLUL
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0008283	cell proliferation	18662667

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Ligand binding site mutations for GLUL

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R299	R299C	COAD	2
A191	A191V	COAD	1
R324	P326R	LUSC	1
E136	Y137H	STAD	1
A191	A191V	STAD	1
R319	A321T	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for GLUL

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R324	P326R	-1.1716808
R319	A321T	-0.85143703
R299	R299C	-0.83328178
A191	A191V	-0.74216424
E136	Y137H	-0.53673743

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GLUL from PDB

PDB ID	PDB title	PDB structure
2OJW	Crystal structure of human glutamine synthetase in complex with ADP and phosphate

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Differential gene expression and gene-gene network for GLUL

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of GLUL and the right PPI network was created from samples without mutations in the LBS of GLUL. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for GLUL

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C2239176	Carcinoma, Hepatocellular	9	Biomarker
umls:C0028754	Obesity	2	Biomarker
umls:C0023904	Liver Neoplasms, Experimental	2	Biomarker
umls:C1864910	Glutamine deficiency, congenital	1	Biomarker, GeneticVariation
umls:C0752109	Brain Diseases, Metabolic, Inborn	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for GLUL

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|investigational\|nutraceutical	DB00130	L-Glutamine	Small molecule
Nutraceutical	DB00142	L-Glutamic Acid	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GLUL go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
ADP		ADP	2ojw	D	A191 R319 R324
ADP		ADP	2qc8	G	A191 R319 R324
ADP		ADP	2qc8	J	A191 R319 R324
ADP		ADP	2qc8	D	A191 R324
ADP		ADP	2qc8	F	A191 R324
ADP		ADP	2qc8	H	A191 R324
MN		MANGANESE(2+)	2ojw	A	E136
MN		MANGANESE(2+)	2ojw	A	E136
MN		MANGANESE(2+)	2ojw	B	E136
MN		MANGANESE(2+)	2ojw	B	E136
MN		MANGANESE(2+)	2ojw	C	E136
MN		MANGANESE(2+)	2ojw	C	E136
MN		MANGANESE(2+)	2ojw	D	E136
MN		MANGANESE(2+)	2ojw	D	E136
MN		MANGANESE(2+)	2ojw	E	E136
MN		MANGANESE(2+)	2ojw	E	E136
MN		MANGANESE(2+)	2qc8	A	E136
MN		MANGANESE(2+)	2qc8	B	E136
MN		MANGANESE(2+)	2qc8	C	E136
MN		MANGANESE(2+)	2qc8	D	E136
MN		MANGANESE(2+)	2qc8	E	E136
MN		MANGANESE(2+)	2qc8	F	E136
MN		MANGANESE(2+)	2qc8	G	E136
MN		MANGANESE(2+)	2qc8	H	E136
MN		MANGANESE(2+)	2qc8	I	E136
MN		MANGANESE(2+)	2qc8	J	E136
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	A	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	B	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	C	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	D	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	E	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	F	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	G	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	H	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	I	E136 R299 R319
P3S		L-METHIONINE-S-SULFOXIMINE PHOSPHATE	2qc8	J	E136 R299 R319
PO4		PHOSPHATE ION	2ojw	A	E136 R319
PO4		PHOSPHATE ION	2ojw	B	E136 R319
PO4		PHOSPHATE ION	2ojw	C	E136 R319
PO4		PHOSPHATE ION	2ojw	D	E136 R319
PO4		PHOSPHATE ION	2ojw	E	E136 R319
ADP		ADP	2ojw	A	R319 R324
ADP		ADP	2ojw	B	R319 R324
ADP		ADP	2ojw	C	R319 R324
ADP		ADP	2ojw	E	R319 R324
ADP		ADP	2qc8	A	R319 R324
ADP		ADP	2qc8	B	R319 R324
ADP		ADP	2qc8	E	R319 R324
ADP		ADP	2qc8	I	R319 R324
MN		MANGANESE(2+)	2ojw	C	R324
MN		MANGANESE(2+)	2qc8	A	R324
MN		MANGANESE(2+)	2qc8	B	R324
MN		MANGANESE(2+)	2qc8	C	R324
ADP		ADP	2qc8	C	R324
MN		MANGANESE(2+)	2qc8	D	R324
MN		MANGANESE(2+)	2qc8	E	R324
MN		MANGANESE(2+)	2qc8	F	R324
MN		MANGANESE(2+)	2qc8	G	R324
MN		MANGANESE(2+)	2qc8	I	R324
MN		MANGANESE(2+)	2qc8	J	R324

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Conservation information for LBS of GLUL

Multiple alignments for P15104 in multiple species

LBS	AA sequence	# species	Species
A191	AGINISGINGE	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
A191	AGVKIAGTNAE	1	Homo sapiens
A191	AGIDFAGTNAE	1	Drosophila melanogaster
A191	AGVKIGGTNAE	1	Gallus gallus
A191	AGVKITGTNAE	1	Mus musculus
A191	AGIKITGTNAE	1	Rattus norvegicus
A191	AGIKIGGTNAE	1	Bos taurus
A191	AGINVSGTNGE	1	Arabidopsis thaliana
A191	AGINISGINAE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A191	AGVKISGTNAE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A191	AGLRISGINAE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A191	AGVNISGINAE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A191	AGLEISGINAE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E134	PWFGMEQEYTL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E134	PWYGIEQEYTL	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
E134	IWFGLEQEYTL	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E134	PWFGIEQEYTL	1	Drosophila melanogaster
E134	TWYGIEQEYTL	1	Arabidopsis thaliana
E134	TWFGIEQEYTM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E134	PWFGLEQEYTL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E134	MWFGLEQEYTL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E136	FGMEQEYTLMG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E136	YGIEQEYTLLQ	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E136	FGLEQEYTLFD	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E136	FGIEQEYTLLD	1	Drosophila melanogaster
E136	FGMEQEYTLLG	1	Gallus gallus
E136	FGIEQEYTMLD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E136	FGLEQEYTLLD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E196	SGINAEVMPSQ	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (str
E196	AGTNAEVMPAQ	2	Homo sapiens, Drosophila melanogaster
E196	GGTNAEVMPAQ	2	Gallus gallus, Bos taurus
E196	TGTNAEVMPAQ	2	Mus musculus, Rattus norvegicus
E196	SGINGEVMPGQ	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
E196	SGTNGEVMPGQ	1	Arabidopsis thaliana
E196	SGTNAEVMPAQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E203	MPAQWEFQIGP	5	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
E203	MPGQWEFQVGP	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E203	MPSQWEFQVGP	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E203	MPAQWEFQVGP	2	Gallus gallus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E203	MPSQWEYQVGP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E305	LTGFHETSNIN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E305	LTGRHETGSID	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E305	LVGRLETSSID	1	Drosophila melanogaster
E305	LTGFHETSSIH	1	Gallus gallus
E305	LTGRHETADIN	1	Oryza sativa subsp. japonica
E305	LTGHHETADIN	1	Arabidopsis thaliana
E305	LTGKHETADIN	1	Arabidopsis thaliana
E305	LTGRHETASMA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E305	LTGRHETASMS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E305	LTGRHETASMT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E338	KKGYFEDRRPS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E338	GKGYFEDRRPA	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E338	GYGYFEDRRPA	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E338	GKGYLEDRRPS	1	Drosophila melanogaster
E338	KKGYFEDRGPS	1	Gallus gallus
E338	GCGYFEDRRPA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E338	GFGYFEDRRPA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F131	NQHPWFGMEQE	3	Homo sapiens, Gallus gallus, Mus musculus
F131	AEVPWYGIEQE	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
F131	DQEPWFGIEQE	1	Drosophila melanogaster
F131	SQHPWFGMEQE	1	Rattus norvegicus
F131	NQRPWFGMEQE	1	Bos taurus
F131	AEETWYGIEQE	1	Arabidopsis thaliana
F131	DKETWFGIEQE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F131	DQVPWFGLEQE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F131	AADIWFGLEQE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F131	DAEMWFGLEQE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F131	DEEIWFGLEQE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G132	QHPWFGMEQEY	4	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G132	EVPWYGIEQEY	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
G132	QEPWFGIEQEY	1	Drosophila melanogaster
G132	QRPWFGMEQEY	1	Bos taurus
G132	EETWYGIEQEY	1	Arabidopsis thaliana
G132	KETWFGIEQEY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G132	QVPWFGLEQEY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G132	ADIWFGLEQEY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G132	AEMWFGLEQEY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G132	EEIWFGLEQEY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G207	WEFQIGPCEGI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G207	WEFQVGPCEGI	2	Gallus gallus, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G207	WEFQVGPSVGI	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
G207	WEFQVGPCTGI	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G207	WEFQIGPA-GI	1	Drosophila melanogaster
G207	WEFQVGPTVGI	1	Arabidopsis thaliana
G207	WEYQVGPCAGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G207	WEFQVGPCDGI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G249	PGNWNGAGCHT	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G249	PGDWNGAGAHT	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
G249	KGDWNGAGCHT	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G249	EGQWNGAGAHT	1	Drosophila melanogaster
G249	LGDWNGAGCHT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G249	PGDWNGAGLHT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H253	NGAGCHTNFST	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
H253	NGAGCHTNVST	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (str
H253	NGAGAHTNFST	2	Drosophila melanogaster, Oryza sativa subsp. japonica
H253	NGAGAHTNYST	2	Arabidopsis thaliana, Arabidopsis thaliana
H253	NGAGLHTNFST	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N255	AGCHTNFSTKA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N255	AGAHTNYSTKS	2	Arabidopsis thaliana, Arabidopsis thaliana
N255	AGAHTNFSTKE	1	Drosophila melanogaster
N255	AGCHTNFSTKN	1	Gallus gallus
N255	AGAHTNFSTKS	1	Oryza sativa subsp. japonica
N255	AGCHTNVSTKD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N255	AGLHTNFSTEN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N255	AGCHTNVSTRE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N255	AGCHTNVSTKL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N255	AGCHTNVSTKE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P208	EFQIGPCEGIR	2	Mus musculus, Rattus norvegicus
P208	EFQIGPCEGIS	1	Homo sapiens
P208	EFQIGPA-GIK	1	Drosophila melanogaster
P208	EFQVGPCEGIE	1	Gallus gallus
P208	EFQIGPCEGID	1	Bos taurus
P208	EFQVGPSVGIA	1	Oryza sativa subsp. japonica
P208	EFQVGPSVGIS	1	Arabidopsis thaliana
P208	EFQVGPTVGIA	1	Arabidopsis thaliana
P208	EYQVGPCAGIE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P208	EFQVGPCDGIE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P208	EFQVGPCTGIT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P208	EFQVGPCEGIA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P208	EFQVGPCTGID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q205	AQWEFQIGPCE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q205	GQWEFQVGPSV	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
Q205	SQWEFQVGPCT	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q205	AQWEFQIGPA-	1	Drosophila melanogaster
Q205	AQWEFQVGPCE	1	Gallus gallus
Q205	GQWEFQVGPTV	1	Arabidopsis thaliana
Q205	SQWEYQVGPCA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q205	AQWEFQVGPCD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q205	SQWEFQVGPCE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R299	LDNARRLTGFH	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R299	KDNERRLVGRL	1	Drosophila melanogaster
R299	EGNERRLTGRH	1	Oryza sativa subsp. japonica
R299	EGNERRLTGHH	1	Arabidopsis thaliana
R299	EGNERRLTGKH	1	Arabidopsis thaliana
R299	DDNDLRLTGRH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R299	EGNDKRLTGRH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R299	SDNELRLTGRH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R299	ADNEQRLTGRH	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R299	SDNDMRLTGRH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R319	AGVANRGASIR	3	Gallus gallus, Mus musculus, Bos taurus
R319	WGVANRGASIR	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
R319	AGVANRSASIR	2	Homo sapiens, Rattus norvegicus
R319	SGVANRGASIR	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R319	WGVANRAVSVR	1	Drosophila melanogaster
R319	YGVADRGASVR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R319	YGVANRGASIR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R319	SGVANRGSSIR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R324	RGASIRVGRDT	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
R324	RGASIRIPRTV	2	Mus musculus, Bos taurus
R324	RGASIRIPRSV	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R324	RSASIRIPRTV	1	Homo sapiens
R324	RAVSVRVPRGV	1	Drosophila melanogaster
R324	RGASIRIPRNV	1	Gallus gallus
R324	RSASIRIPRIV	1	Rattus norvegicus
R324	RGASVRIPRSV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R324	RGASIRIPREC	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R324	RGSSIRIPRSV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R340	GYFEDRRPASN	7	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lact
R340	GYFEDRRPSAN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R340	GYLEDRRPSSN	1	Drosophila melanogaster
R340	GYFEDRGPSAN	1	Gallus gallus
R340	GYFEDRRPASS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S257	CHTNFSTKAMR	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S257	AHTNYSTKSMR	2	Arabidopsis thaliana, Arabidopsis thaliana
S257	AHTNFSTKEMR	1	Drosophila melanogaster
S257	CHTNFSTKNMR	1	Gallus gallus
S257	AHTNFSTKSMR	1	Oryza sativa subsp. japonica
S257	CHTNVSTKDTR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S257	LHTNFSTENMR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S257	CHTNVSTREMR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S257	CHTNVSTKLMR	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S257	CHTNVSTKEMR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T306	TGFHETSNIND	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T306	VGRLETSSIDK	1	Drosophila melanogaster
T306	TGFHETSSIHE	1	Gallus gallus
T306	TGRHETADINT	1	Oryza sativa subsp. japonica
T306	TGHHETADINT	1	Arabidopsis thaliana
T306	TGKHETADINT	1	Arabidopsis thaliana
T306	TGRHETGSIDK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T306	TGRHETGSIDS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T306	TGRHETASMAT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T306	TGRHETASMST	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T306	TGRHETASMTA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W130	SNQHPWFGMEQ	3	Homo sapiens, Gallus gallus, Mus musculus
W130	SDQEPWFGIEQ	1	Drosophila melanogaster
W130	SSQHPWFGMEQ	1	Rattus norvegicus
W130	SNQRPWFGMEQ	1	Bos taurus
W130	VAEVPWYGIEQ	1	Oryza sativa subsp. japonica
W130	IAEVPWYGIEQ	1	Arabidopsis thaliana
W130	VAEETWYGIEQ	1	Arabidopsis thaliana
W130	ADKETWFGIEQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W130	ADQVPWFGLEQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W130	RAADIWFGLEQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W130	KDAEMWFGLEQ	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W130	KDEEIWFGLEQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y162	PQGPYYCGVGA	10	Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70
Y162	PQGPYYCAAGA	1	Oryza sativa subsp. japonica
Y162	PQGPYYCSIGA	1	Arabidopsis thaliana
Y162	PQGPFYCGVGT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y162	PQGPYYCGVGT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y336	QEKKGYFEDRR	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y336	KEGKGYFEDRR	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
Y336	KEGYGYFEDRR	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y336	TAGKGYLEDRR	1	Drosophila melanogaster
Y336	HEKKGYFEDRG	1	Gallus gallus
Y336	QAGKGYFEDRR	1	Arabidopsis thaliana
Y336	MNGCGYFEDRR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y336	AKGYGYFEDRR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y336	KEGFGYFEDRR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)