mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GNAI1
Gene summary
Basic gene Info.Gene symbolGNAI1
Gene nameguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
SynonymsGi
CytomapUCSC genome browser: 7q21
Type of geneprotein-coding
RefGenesNM_001256414.1,
NM_002069.5,
DescriptionGi1 protein alpha subunitadenylate cyclase-inhibiting G alpha proteinguanine nucleotide-binding protein G(i) subunit alpha-1
Modification date20141207
dbXrefs MIM : 139310
HGNC : HGNC
Ensembl : ENSG00000127955
HPRD : 00756
Vega : OTTHUMG00000023523
ProteinUniProt: P63096
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GNAI1
BioGPS: 2770
PathwayNCI Pathway Interaction Database: GNAI1
KEGG: GNAI1
REACTOME: GNAI1
Pathway Commons: GNAI1
ContextiHOP: GNAI1
ligand binding site mutation search in PubMed: GNAI1
UCL Cancer Institute: GNAI1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for GNAI1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S44S44FBRCA1
R105R105HCOAD1
R208R208QCOAD1
R208R208LCOAD1
G89M88IKIRC1
K248M247ILUAD1
A104D102HLUAD1
I212H213NUCEC1
A326A326VUCEC1
R86A87TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GNAI1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R208R208Q-1.8937707
R208R208L-1.322279
R86A87T-1.1273997
I212H213N-1.0972841
A104D102H-0.98955502
R105R105H-0.82284741
G89M88I-0.38799836
A326A326V-0.36490165
K248M247I-0.32869201
S44S44F-0.088198386
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GNAI1 from PDB

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Differential gene expression and gene-gene network for GNAI1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GNAI1 and the right PPI network was created from samples without mutations in the LBS of GNAI1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GNAI1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0002622Amnesia1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GNAI1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB04315Guanosine-5'-DiphosphateSmall molecule
ExperimentalDB04444Tetrafluoroaluminate IonSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GNAI1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GLU,ASP,PHE,PHE,SER,LEU,ILE,LEU,ARG,SER,GLN,ALA,LYS,ARG,MET,ASP,GLU,GLN,ARG,VAL,LEU,LEU,GLN,ARG)4g5qCI212
IIIPeptide ligand (THR,TRP,TYR,ASP,PHE,LEU)3qe0AI212 K248
IIIPeptide ligand (ASP,PHE,PHE,SER,LEU,ILE,LEU,ARG,SER,GLN,ALA,LYS,ARG,MET,ASP,GLU,GLN,ARG,VAL,LEU,LEU)4g5qAK248
IIIPeptide ligand (SER,ARG,VAL,THR,TRP,TYR,ASP,PHE,LEU,MET,GLU,ASP)1y3aAR208 I212 K248
IIIPeptide ligand (SER,ARG,VAL,THR,TRP,TYR,ASP,PHE,LEU,MET,GLU)3qe0BR208 I212 K248
IIIPeptide ligand (ARG,GLY,TYR,TYR,HIS,GLY,ILE,TRP,VAL,GLY,GLU)2g83AR208 K248
IIIPeptide ligand (ARG,GLY,TYR,TYR,HIS,GLY,ILE,TRP,VAL,GLY,GLU)2g83BR208 K248
IIIPeptide ligand (ASP,ILE,GLU,GLY,LEU,VAL,GLU,LEU,LEU,ASN,ARG,VAL,GLN,SER,SER)3qi2AR208 K248
IIIPeptide ligand (HIS,ASP,GLN,ARG,GLY,LEU,LEU,ARG,LYS,GLU,ASP,LEU,VAL,LEU,PRO,GLU,PHE,LEU)3qi2AR86 G89 A104 R105
IIIPeptide ligand (ASP,GLN,ARG,GLY,LEU,LEU,ARG,LYS,GLU,ASP,LEU,VAL,LEU,PRO,GLU,PHE,LEU,GLN)3qi2BR86 G89 A104 R105
GDPGUANOSINE-5'-DIPHOSPHATE1kjyAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE1y3aAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE1y3aBS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE1y3aCS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE1y3aDS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2g83AS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2g83BS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2gtpAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2gtpBS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2ik8AS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2ik8CS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2om2AS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2xnsAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE2xnsBS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3onwAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3onwBS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3qe0AS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3qe0BS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3qe0CS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3qi2AS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3qi2BS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3umrAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE3umsAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE4g5qAS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE4g5qBS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE4g5qCS44 A326
GDPGUANOSINE-5'-DIPHOSPHATE4g5qDS44 A326


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Conservation information for LBS of GNAI1
Multiple alignments for P63096 in multiple species
LBSAA sequence# speciesSpecies
A104ARADDARQLFV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A104DHESDARKLLM1Caenorhabditis elegans
A104SRTDIARQFFT1Drosophila melanogaster
A104TRADDARQLFV1Gallus gallus
A111QLFVLAGAAEE5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
A111KLLMFSTTGEE1Caenorhabditis elegans
A111QFFTHASAADE1Drosophila melanogaster
A326THFTCATDTKN5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
A326TQFTCATDTNN1Caenorhabditis elegans
A326THLTCATDTNN1Drosophila melanogaster
A41LLLLGAGESGK7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
A71CKQYKAVVYSN5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
A71RKVFRGVVYGN1Caenorhabditis elegans
A71CEEYRRVVFSN1Drosophila melanogaster
A83IQSIIAIIRAM5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
A83ILSLNAIIHAM1Caenorhabditis elegans
A83VQSLMVIIRAM1Drosophila melanogaster
C325YTHFTCATDTK5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
C325YTQFTCATDTN1Caenorhabditis elegans
C325YTHLTCATDTN1Drosophila melanogaster
D150EYQLNDSAAYY5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
D150EYQLNDSAGYY2Caenorhabditis elegans, Drosophila melanogaster
D200HFKMFDVGGQR5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
D200LFLVFDVGGQR1Caenorhabditis elegans
D200HFKLFDVGGQR1Drosophila melanogaster
D237LVLAEDEEMNR6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
D237MVLVEDCQTNR1Caenorhabditis elegans
D272FLNKKDLFEEK7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
E116AGAAEEGFMTA5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
E116STTGEEDELPE1Caenorhabditis elegans
E116ASAADEGILLP1Drosophila melanogaster
E207GGQRSERKKWI7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
E238VLAEDEEMNRM6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
E238VLVEDCQTNRM1Caenorhabditis elegans
E245MNRMHESMKLF5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
E245TNRMRESLKLF1Caenorhabditis elegans
E245MNRMIESLKLF1Drosophila melanogaster
E43LLGAGESGKST7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
F108DARQLFVLAGA5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
F108DARKLLMFSTT1Caenorhabditis elegans
F108IARQFFTHASA1Drosophila melanogaster
F215KWIHCFEGVTA6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
F215KWIHCFEDVTA1Caenorhabditis elegans
F259CNNKWFTDTSI5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
F259CNNKWFVETSI1Caenorhabditis elegans
F259CNSKWFVETSI1Drosophila melanogaster
G112LFVLAGAAEEG5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G112LLMFSTTGEED1Caenorhabditis elegans
G112FFTHASAADEG1Drosophila melanogaster
G202KMFDVGGQRSE5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G202LVFDVGGQRSE1Caenorhabditis elegans
G202KLFDVGGQRSE1Drosophila melanogaster
G203MFDVGGQRSER5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G203VFDVGGQRSER1Caenorhabditis elegans
G203LFDVGGQRSER1Drosophila melanogaster
G40KLLLLGAGESG7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G42LLLGAGESGKS7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G45GAGESGKSTIV6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G45GAGESGKSTIL1Caenorhabditis elegans
G89IIRAMGRLKID5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
G89IIHAMEQLKIS1Caenorhabditis elegans
G89IIRAMGRLKIE1Drosophila melanogaster
I212ERKKWIHCFEG6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
I212ERKKWIHCFED1Caenorhabditis elegans
I253KLFDSICNNKW6Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
I253KLFDSICNSKW1Drosophila melanogaster
I78VYSNTIQSIIA5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
I78VYGNIILSLNA1Caenorhabditis elegans
I78VFSNTVQSLMV1Drosophila melanogaster
I85SIIAIIRAMGR5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
I85SLNAIIHAMEQ1Caenorhabditis elegans
I85SLMVIIRAMGR1Drosophila melanogaster
K180LRTRVKTTGIV5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
K180LRTRIKTTGIV1Caenorhabditis elegans
K180LRTRVKTTGII1Drosophila melanogaster
K209QRSERKKWIHC7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
K248MHESMKLFDSI5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
K248MRESLKLFDSI1Caenorhabditis elegans
K248MIESLKLFDSI1Drosophila melanogaster
K257SICNNKWFTDT5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
K257SICNNKWFVET1Caenorhabditis elegans
K257SICNSKWFVET1Drosophila melanogaster
K270ILFLNKKDLFE7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
K46AGESGKSTIVK6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
K46AGESGKSTILK1Caenorhabditis elegans
L148SREYQLNDSAA5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
L148SREYQLNDSAG2Caenorhabditis elegans, Drosophila melanogaster
L175TQQDVLRTRVK6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
L175TQDDILRTRIK1Caenorhabditis elegans
L249HESMKLFDSIC5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
L249RESLKLFDSIC1Caenorhabditis elegans
L249IESLKLFDSIC1Drosophila melanogaster
L273LNKKDLFEEKI7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
L39VKLLLLGAGES6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
L39IKLLLLGAGES1Caenorhabditis elegans
N149REYQLNDSAAY5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
N149REYQLNDSAGY2Caenorhabditis elegans, Drosophila melanogaster
N256DSICNNKWFTD5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
N256DSICNNKWFVE1Caenorhabditis elegans
N256DSICNSKWFVE1Drosophila melanogaster
N269IILFLNKKDLF7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
N76AVVYSNTIQSI5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
N76GVVYGNIILSL1Caenorhabditis elegans
N76RVVFSNTVQSL1Drosophila melanogaster
Q147RSREYQLNDSA7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
Q204FDVGGQRSERK7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
Q68EEECKQYKAVV5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
Q68TEERKVFRGVV1Caenorhabditis elegans
Q68QEECEEYRRVV1Drosophila melanogaster
Q79YSNTIQSIIAI5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
Q79YGNIILSLNAI1Caenorhabditis elegans
Q79FSNTVQSLMVI1Drosophila melanogaster
R105RADDARQLFVL5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R105HESDARKLLMF1Caenorhabditis elegans
R105RTDIARQFFTH1Drosophila melanogaster
R176QQDVLRTRVKT6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R176QDDILRTRIKT1Caenorhabditis elegans
R178DVLRTRVKTTG6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R178DILRTRIKTTG1Caenorhabditis elegans
R205DVGGQRSERKK7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R208GQRSERKKWIH7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R242DEEMNRMHESM5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R242DCQTNRMRESL1Caenorhabditis elegans
R242DEEMNRMIESL1Drosophila melanogaster
R86IIAIIRAMGRL5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
R86LNAIIHAMEQL1Caenorhabditis elegans
R86LMVIIRAMGRL1Drosophila melanogaster
S151YQLNDSAAYYL5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
S151YQLNDSAGYYL2Caenorhabditis elegans, Drosophila melanogaster
S206VGGQRSERKKW7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
S252MKLFDSICNNK5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
S252LKLFDSICNNK1Caenorhabditis elegans
S252LKLFDSICNSK1Drosophila melanogaster
S44LGAGESGKSTI7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
S47GESGKSTIVKQ6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
S47GESGKSTILKQ1Caenorhabditis elegans
S75KAVVYSNTIQS5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
S75RGVVYGNIILS1Caenorhabditis elegans
S75RRVVFSNTVQS1Drosophila melanogaster
T177QDVLRTRVKTT6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
T177DDILRTRIKTT1Caenorhabditis elegans
T181RTRVKTTGIVE5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
T181RTRIKTTGIVE1Caenorhabditis elegans
T181RTRVKTTGIIE1Drosophila melanogaster
T327HFTCATDTKNV5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
T327QFTCATDTNNI1Caenorhabditis elegans
T327HLTCATDTNNV1Drosophila melanogaster
T48ESGKSTIVKQM6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
T48ESGKSTILKQM1Caenorhabditis elegans
V179VLRTRVKTTGI6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
V179ILRTRIKTTGI1Caenorhabditis elegans
V201FKMFDVGGQRS5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
V201FLVFDVGGQRS1Caenorhabditis elegans
V201FKLFDVGGQRS1Drosophila melanogaster
V72KQYKAVVYSNT5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
V72KVFRGVVYGNI1Caenorhabditis elegans
V72EEYRRVVFSNT1Drosophila melanogaster
W211SERKKWIHCFE7Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
W258ICNNKWFTDTS5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus
W258ICNNKWFVETS1Caenorhabditis elegans
W258ICNSKWFVETS1Drosophila melanogaster


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