|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for GOT1 |
 Gene summary |
| Basic gene Info. | Gene symbol | GOT1 |
| Gene name | glutamic-oxaloacetic transaminase 1, soluble | |
| Synonyms | ASTQTL1|GIG18|cAspAT|cCAT | |
| Cytomap | UCSC genome browser: 10q24.1-q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002079.2, | |
| Description | aspartate aminotransferase 1aspartate aminotransferase, cytoplasmicaspartate transaminase 1cysteine aminotransferase, cytoplasmiccysteine transaminase, cytoplasmicglutamate oxaloacetate transaminase 1growth-inhibiting protein 18transaminase A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 138180 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120053 | ||
| HPRD : 00687 | ||
| Vega : OTTHUMG00000018882 | ||
| Protein | UniProt: P17174 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GOT1 | |
| BioGPS: 2805 | ||
| Pathway | NCI Pathway Interaction Database: GOT1 | |
| KEGG: GOT1 | ||
| REACTOME: GOT1 | ||
| Pathway Commons: GOT1 | ||
| Context | iHOP: GOT1 | |
| ligand binding site mutation search in PubMed: GOT1 | ||
| UCL Cancer Institute: GOT1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006533 | aspartate catabolic process | 2241899 |
| Top |
| Ligand binding site mutations for GOT1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R267 | G269W | LUAD | 1 | Y226 | Q227E | LUAD | 1 | R267 | R267K | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for GOT1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R267 | G269W | 0.23666067 | R267 | R267K | -1.6761071 | Y226 | Q227E | -0.030223331 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GOT1 from PDB |
| Top |
| Differential gene expression and gene-gene network for GOT1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for GOT1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for GOT1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Nutraceutical | DB00114 | Pyridoxal Phosphate | Small molecule |  |
| Approved|nutraceutical | DB00128 | L-Aspartic Acid | Small molecule |  |
| Nutraceutical | DB00142 | L-Glutamic Acid | Small molecule |  |
| Approved|nutraceutical | DB00151 | L-Cysteine | Small molecule |  |
| Experimental | DB04299 | Maleic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of GOT1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PLP | PYRIDOXAL 5'-PHOSPHATE | 3ii0 | A | Y226 R267 | PLP | PYRIDOXAL 5'-PHOSPHATE | 3ii0 | B | Y226 R267 | PLP | PYRIDOXAL 5'-PHOSPHATE | 3ii0 | C | Y226 R267 | PLP | PYRIDOXAL 5'-PHOSPHATE | 3ii0 | D | Y226 R267 |
| Top |
| Conservation information for LBS of GOT1 |
| Multiple alignments for P17174 in multiple species |
| LBS | AA sequence | # species | Species | A225 | PFFDSAYQGFA | 8 | Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Gallus gallus, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | A225 | ALFDTAYQGFA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A225 | VVFDIAYQGFA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A225 | TFFDIAYQGFA | 1 | Caenorhabditis elegans | D223 | LFPFFDSAYQG | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | D223 | HIALFDTAYQG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D223 | HLVVFDIAYQG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D223 | LMPFFDSAYQG | 1 | Arabidopsis thaliana | D223 | LLPFFDSAYQG | 1 | Oryza sativa subsp. japonica | D223 | LFTFFDIAYQG | 1 | Caenorhabditis elegans | G108 | GVQSLGGTGAL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | G108 | SVQSLSGTGAL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G108 | SMQSVSGTGAN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G108 | TVECLSGTGSL | 1 | Arabidopsis thaliana | G108 | TVQCLSGTGSL | 1 | Oryza sativa subsp. japonica | G108 | GVQCLSGTGAL | 1 | Caenorhabditis elegans | G108 | SVQGLGGTGAL | 1 | Gallus gallus | G108 | GVQCLGGTGAL | 1 | Bos taurus | G109 | VQSLGGTGALR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | G109 | VQSLSGTGALH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G109 | MQSVSGTGANF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G109 | VECLSGTGSLR | 1 | Arabidopsis thaliana | G109 | VQCLSGTGSLR | 1 | Oryza sativa subsp. japonica | G109 | VQCLSGTGALR | 1 | Caenorhabditis elegans | G109 | VQGLGGTGALR | 1 | Gallus gallus | G109 | VQCLGGTGALR | 1 | Bos taurus | K259 | AQSFSKNFGLY | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | K259 | AQSYAKNMGLY | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | K259 | CQSFAKNAGMY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K259 | CQSFAKNMGLY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K259 | SQSFAKNFGLY | 1 | Caenorhabditis elegans | N195 | HACAHNPTGTD | 4 | Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | N195 | HACAHNPTGID | 3 | Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Pan troglodytes | N195 | HACAHNPTGVD | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | N195 | HSCAHNPTGLD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N195 | HGCAHNPTGMD | 1 | Caenorhabditis elegans | R267 | GLYNERVGNLT | 6 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | R267 | GLYGERVGALS | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | R267 | GMYGERVGCFH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R267 | GLYGERTGCMH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R267 | GLYNERVGNLS | 1 | Gallus gallus | S256 | LFCAQSFSKNF | 4 | Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus | S256 | FFCAQSFSKNF | 2 | Homo sapiens, Pan troglodytes | S256 | VFVCQSFAKNA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S256 | FFVCQSFAKNM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S256 | CLVAQSYAKNM | 1 | Arabidopsis thaliana | S256 | LLMAQSYAKNM | 1 | Oryza sativa subsp. japonica | S256 | MVVSQSFAKNF | 1 | Caenorhabditis elegans | S258 | CAQSFSKNFGL | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | S258 | VCQSFAKNAGM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S258 | VCQSFAKNMGL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S258 | VAQSYAKNMGL | 1 | Arabidopsis thaliana | S258 | MAQSYAKNMGL | 1 | Oryza sativa subsp. japonica | S258 | VSQSFAKNFGL | 1 | Caenorhabditis elegans | T110 | QSLGGTGALRI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | T110 | QSLSGTGALHI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T110 | QSVSGTGANFL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T110 | ECLSGTGSLRV | 1 | Arabidopsis thaliana | T110 | QCLSGTGSLRV | 1 | Oryza sativa subsp. japonica | T110 | QCLSGTGALRA | 1 | Caenorhabditis elegans | T110 | QGLGGTGALRI | 1 | Gallus gallus | T110 | QCLGGTGALRI | 1 | Bos taurus | W141 | VSSPTWENHNA | 3 | Homo sapiens, Mus musculus, Pan troglodytes | W141 | VSSPTWENHNG | 2 | Rattus norvegicus, Bos taurus | W141 | LSKPTWANHMA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W141 | ISNPTWPVHRT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W141 | ITQPTWGNHPK | 1 | Arabidopsis thaliana | W141 | IPQPTWGNHPK | 1 | Oryza sativa subsp. japonica | W141 | VSNPTWGNHKL | 1 | Caenorhabditis elegans | W141 | VSSPTWENHNS | 1 | Gallus gallus | Y226 | FFDSAYQGFAS | 8 | Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Gallus gallus, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos taurus | Y226 | LFDTAYQGFAT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y226 | VFDIAYQGFAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y226 | FFDIAYQGFAS | 1 | Caenorhabditis elegans |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |