mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPP2R3B
Gene summary
Basic gene Info.Gene symbolPPP2R3B
Gene nameprotein phosphatase 2, regulatory subunit B'', beta
CytomapUCSC genome browser: Xp22.33; Yp11.3
Type of geneprotein-coding
DescriptionNY-REN-8 antigenPP2A, subunit B, PR48 isoformprotein phosphatase 2 (formerly 2A), regulatory subunit B'', betaserine/threonine protein phosphatase 2A, 48kDa regulatory subunit Bserine/threonine-protein phosphatase 2A regulatory subunit B'' subunit bet
Modification date20141207
dbXrefs MIM : 300339
Ensembl : ENSG00000167393
HPRD : 02276
Vega : OTTHUMG00000021052
ProteinUniProt: Q9Y5P8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPP2R3B
BioGPS: 28227
PathwayNCI Pathway Interaction Database: PPP2R3B
Pathway Commons: PPP2R3B
ContextiHOP: PPP2R3B
ligand binding site mutation search in PubMed: PPP2R3B
UCL Cancer Institute: PPP2R3B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PPP2R3B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PPP2R3B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPP2R3B from PDB

Differential gene expression and gene-gene network for PPP2R3B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPP2R3B and the right PPI network was created from samples without mutations in the LBS of PPP2R3B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PPP2R3B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PPP2R3B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPP2R3B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)4i5lBD327 D329
CACALCIUM(2+)4i5lED327 D329
CACALCIUM(2+)4i5nED327 D329
CACALCIUM(2+)4mewAD327 D329

Conservation information for LBS of PPP2R3B
Multiple alignments for Q9Y5P8 in multiple species
LBSAA sequence# speciesSpecies
A407LDGDGALSMFE1Homo sapiens
A407LDGNGVITSNE1Arabidopsis thaliana
A407LDGDGVITPNE1Arabidopsis thaliana
D327KFWELDTDHDL1Homo sapiens
D327KFWELDGDHDC1Arabidopsis thaliana
D327RFWELDGDHDF1Arabidopsis thaliana
D329WELDTDHDLLI1Homo sapiens
D329WELDGDHDCFI1Arabidopsis thaliana
D329WELDGDHDFLI1Arabidopsis thaliana
D331LDTDHDLLIDA1Homo sapiens
D331LDGDHDCFIDK1Arabidopsis thaliana
D331LDGDHDFLIDK1Arabidopsis thaliana
D401WFRCMDLDGDG1Homo sapiens
D401WFKCVDLDGNG1Arabidopsis thaliana
D401WFKCIDLDGDG1Arabidopsis thaliana
D403RCMDLDGDGAL1Homo sapiens
D403KCVDLDGNGVI1Arabidopsis thaliana
D403KCIDLDGDGVI1Arabidopsis thaliana
D405MDLDGDGALSM1Homo sapiens
D405VDLDGNGVITS1Arabidopsis thaliana
D405IDLDGDGVITP1Arabidopsis thaliana
E412ALSMFELEYFY1Homo sapiens
E412VITSNEMQFFF1Arabidopsis thaliana
E412VITPNEMQFFY1Arabidopsis thaliana
L333TDHDLLIDADD1Homo sapiens
L333GDHDCFIDKDN1Arabidopsis thaliana
L333GDHDFLIDKEN1Arabidopsis thaliana

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