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mutLBSgeneDB |
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| Gene summary for ANG |
 Gene summary |
| Basic gene Info. | Gene symbol | ANG |
| Gene name | angiogenin, ribonuclease, RNase A family, 5 | |
| Synonyms | ALS9|HEL168|RAA1|RNASE4|RNASE5 | |
| Cytomap | UCSC genome browser: 14q11.1-q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001097577.2, NM_001145.4, | |
| Description | RNase 5angiogeninepididymis luminal protein 168ribonuclease 5ribonuclease A A1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 105850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000214274 | ||
| HPRD : 00105 | ||
| Vega : OTTHUMG00000029576 | ||
| Protein | UniProt: P03950 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANG | |
| BioGPS: 283 | ||
| Pathway | NCI Pathway Interaction Database: ANG | |
| KEGG: ANG | ||
| REACTOME: ANG | ||
| Pathway Commons: ANG | ||
| Context | iHOP: ANG | |
| ligand binding site mutation search in PubMed: ANG | ||
| UCL Cancer Institute: ANG | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001525 | angiogenesis | 8448182 | GO:0001666 | response to hypoxia | 10999833 | GO:0001938 | positive regulation of endothelial cell proliferation | 9122172 | GO:0006651 | diacylglycerol biosynthetic process | 2457905 | GO:0009725 | response to hormone | 10999833 | GO:0042327 | positive regulation of phosphorylation | 17125737 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10103013 | GO:0050714 | positive regulation of protein secretion | 2646638 | GO:0090501 | RNA phosphodiester bond hydrolysis | 2424496 |
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| Ligand binding site mutations for ANG |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H138 | H138Y | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ANG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H138 | H138Y | -0.27999939 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ANG from PDB |
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| Differential gene expression and gene-gene network for ANG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ANG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2678468 | Amyotrophic Lateral Sclerosis 9 | 3 | Biomarker, GeneticVariation |
| umls:C0001349 | Acute-Phase Reaction | 1 | Biomarker |
| umls:C0029927 | Ovarian Cysts | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ANG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB03088 | Pyroglutamic Acid | Small molecule |  |
| Nutraceutical|vet_approved | DB04272 | Citric Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ANG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ANG |
| Multiple alignments for P03950 in multiple species |
| LBS | AA sequence | # species | Species | H138 | NGLPVHLDQSI | 2 | Homo sapiens, Pan troglodytes | H138 | NGLPVHFDESF | 1 | Mus musculus | H37 | HFLTQHYDAKP | 2 | Homo sapiens, Pan troglodytes | H37 | KFLTQHHDAKP | 1 | Mus musculus | K64 | LTSPCKDINTF | 2 | Homo sapiens, Pan troglodytes | K64 | LTSPCKDVNTF | 1 | Mus musculus | L139 | GLPVHLDQSIF | 2 | Homo sapiens, Pan troglodytes | L139 | GLPVHFDESFF | 1 | Mus musculus | Q141 | PVHLDQSIFRR | 2 | Homo sapiens, Pan troglodytes | Q141 | PVHFDESFFSL | 1 | Mus musculus | Q36 | THFLTQHYDAK | 2 | Homo sapiens, Pan troglodytes | Q36 | TKFLTQHHDAK | 1 | Mus musculus |
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