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mutLBSgeneDB |
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| Gene summary for ZADH2 |
 Gene summary |
| Basic gene Info. | Gene symbol | ZADH2 |
| Gene name | zinc binding alcohol dehydrogenase domain containing 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 18q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_175907.4, | |
| Description | zinc-binding alcohol dehydrogenase domain-containing protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 15685 | ||
| Protein | UniProt: Q8N4Q0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZADH2 | |
| BioGPS: 284273 | ||
| Pathway | NCI Pathway Interaction Database: ZADH2 | |
| KEGG: ZADH2 | ||
| REACTOME: ZADH2 | ||
| Pathway Commons: ZADH2 | ||
| Context | iHOP: ZADH2 | |
| ligand binding site mutation search in PubMed: ZADH2 | ||
| UCL Cancer Institute: ZADH2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for ZADH2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C204 | C204F | BLCA | 1 | M356 | N354K | COAD | 1 | Q313 | A315S | LUAD | 1 | L281 | S282L | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ZADH2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Q313 | A315S | -0.78655164 | M356 | N354K | -0.3513378 | C204 | C204F | -0.16179801 | L281 | S282L | -0.045519573 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ZADH2 from PDB |
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| Differential gene expression and gene-gene network for ZADH2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ZADH2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ZADH2 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ZADH2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAP | NADP ZWITTERION | 2wek | A | C204 M356 | NAP | NADP ZWITTERION | 2wek | B | C204 M356 | NAP | NADP ZWITTERION | 2x7h | A | C204 M356 | NAP | NADP ZWITTERION | 2x7h | B | C204 M356 | PFN | FENOPROFEN | 2x7h | A | L281 | DIF | DICLOFENAC | 2wek | A | Q313 |
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| Conservation information for LBS of ZADH2 |
| Multiple alignments for Q8N4Q0 in multiple species |
| LBS | AA sequence | # species | Species | A125 | AVAYMAPGSFA | 3 | Homo sapiens, Bos taurus, Mus musculus | A180 | KVLVTAAAGGT | 3 | Homo sapiens, Bos taurus, Mus musculus | A196 | QLSKKAKCHVI | 1 | Homo sapiens | A196 | QLAKKAKCHVI | 1 | Bos taurus | A196 | QLSKIAKCHVI | 1 | Mus musculus | A251 | ESVGGAMFDLA | 3 | Homo sapiens, Bos taurus, Mus musculus | A76 | FVGVNASDINY | 2 | Homo sapiens, Bos taurus | A76 | FVGINASDINY | 1 | Mus musculus | C204 | HVIGTCSSDEK | 2 | Homo sapiens, Mus musculus | C204 | HVIGTCSSAEK | 1 | Bos taurus | C323 | HLLEMCVSGDL | 1 | Homo sapiens | C323 | HLLKMYAGGEL | 1 | Bos taurus | C323 | RLLELYARGDL | 1 | Mus musculus | E149 | PSVKPEYLTLL | 1 | Homo sapiens | E149 | PGLKPEYLTLL | 1 | Bos taurus | E149 | PSVKPEYLTML | 1 | Mus musculus | F271 | LIVIGFISGYQ | 2 | Homo sapiens, Mus musculus | F271 | LIVIGFVSGYQ | 1 | Bos taurus | F303 | ASVQGFFLNHY | 2 | Homo sapiens, Bos taurus | F303 | ASLRGFFLNHY | 1 | Mus musculus | F304 | SVQGFFLNHYL | 2 | Homo sapiens, Bos taurus | F304 | SLRGFFLNHYF | 1 | Mus musculus | F98 | PFDIGFEGIGE | 2 | Homo sapiens, Mus musculus | F98 | PFDAGFEGVGE | 1 | Bos taurus | G183 | VTAAAGGTGQF | 3 | Homo sapiens, Bos taurus, Mus musculus | G184 | TAAAGGTGQFA | 3 | Homo sapiens, Bos taurus, Mus musculus | G249 | VYESVGGAMFD | 3 | Homo sapiens, Bos taurus, Mus musculus | G250 | YESVGGAMFDL | 3 | Homo sapiens, Bos taurus, Mus musculus | G270 | RLIVIGFISGY | 2 | Homo sapiens, Mus musculus | G270 | RLIVIGFVSGY | 1 | Bos taurus | G359 | NYMYMGKNTGK | 1 | Homo sapiens | G359 | DYMYMRKNTGK | 1 | Bos taurus | G359 | DYMYTGKNTGK | 1 | Mus musculus | H318 | QAAMSHLLEMC | 1 | Homo sapiens | H318 | RGAMDHLLKMY | 1 | Bos taurus | H318 | QAAMERLLELY | 1 | Mus musculus | I139 | VVPASIATPVP | 1 | Homo sapiens | I139 | VVPARVAIPVP | 1 | Bos taurus | I139 | VVPASIAIPMP | 1 | Mus musculus | I269 | GRLIVIGFISG | 2 | Homo sapiens, Mus musculus | I269 | GRLIVIGFVSG | 1 | Bos taurus | I272 | IVIGFISGYQT | 1 | Homo sapiens | I272 | IVIGFVSGYQT | 1 | Bos taurus | I272 | IVIGFISGYQS | 1 | Mus musculus | K147 | PVPSVKPEYLT | 1 | Homo sapiens | K147 | PVPGLKPEYLT | 1 | Bos taurus | K147 | PMPSVKPEYLT | 1 | Mus musculus | K165 | AYISLKELGGL | 2 | Homo sapiens, Bos taurus | K165 | AYLSLEELGEL | 1 | Mus musculus | K195 | MQLSKKAKCHV | 1 | Homo sapiens | K195 | VQLAKKAKCHV | 1 | Bos taurus | K195 | VQLSKIAKCHV | 1 | Mus musculus | K209 | CSSDEKSAFLK | 1 | Homo sapiens | K209 | CSSAEKSAFLK | 1 | Bos taurus | K209 | CSSDEKAAFLK | 1 | Mus musculus | L164 | TAYISLKELGG | 2 | Homo sapiens, Bos taurus | L164 | TAYLSLEELGE | 1 | Mus musculus | L192 | QFAMQLSKKAK | 1 | Homo sapiens | L192 | QFAVQLAKKAK | 1 | Bos taurus | L192 | QFAVQLSKIAK | 1 | Mus musculus | L255 | GAMFDLAVDAL | 3 | Homo sapiens, Bos taurus, Mus musculus | L281 | QTPTGLSPVKA | 2 | Homo sapiens, Bos taurus | L281 | QSPTGLSPIKA | 1 | Mus musculus | L305 | VQGFFLNHYLS | 1 | Homo sapiens | L305 | VQGFFLNHYLP | 1 | Bos taurus | L305 | LRGFFLNHYFS | 1 | Mus musculus | L309 | FLNHYLSKYQA | 1 | Homo sapiens | L309 | FLNHYLPEFRG | 1 | Bos taurus | L309 | FLNHYFSKYQA | 1 | Mus musculus | M124 | QAVAYMAPGSF | 3 | Homo sapiens, Bos taurus, Mus musculus | M252 | SVGGAMFDLAV | 3 | Homo sapiens, Bos taurus, Mus musculus | M322 | SHLLEMCVSGD | 1 | Homo sapiens | M322 | DHLLKMYAGGE | 1 | Bos taurus | M322 | ERLLELYARGD | 1 | Mus musculus | M356 | RAVNYMYMGKN | 1 | Homo sapiens | M356 | RAVDYMYMRKN | 1 | Bos taurus | M356 | QAVDYMYTGKN | 1 | Mus musculus | N306 | QGFFLNHYLSK | 1 | Homo sapiens | N306 | QGFFLNHYLPE | 1 | Bos taurus | N306 | RGFFLNHYFSK | 1 | Mus musculus | N361 | MYMGKNTGKIV | 1 | Homo sapiens | N361 | MYMRKNTGKIV | 1 | Bos taurus | N361 | MYTGKNTGKLV | 1 | Mus musculus | N75 | RFVGVNASDIN | 2 | Homo sapiens, Bos taurus | N75 | RFVGINASDIN | 1 | Mus musculus | N80 | NASDINYSAGR | 3 | Homo sapiens, Bos taurus, Mus musculus | P126 | VAYMAPGSFAE | 3 | Homo sapiens, Bos taurus, Mus musculus | P88 | AGRYDPSVKPP | 1 | Homo sapiens | P88 | AGRYDPSVKTP | 1 | Bos taurus | P88 | AGRYDPSLKPP | 1 | Mus musculus | Q313 | YLSKYQAAMSH | 1 | Homo sapiens | Q313 | YLPEFRGAMDH | 1 | Bos taurus | Q313 | YFSKYQAAMER | 1 | Mus musculus | R85 | NYSAGRYDPSV | 2 | Homo sapiens, Bos taurus | R85 | NYSAGRYDPSL | 1 | Mus musculus | S138 | TVVPASIATPV | 1 | Homo sapiens | S138 | TVVPARVAIPV | 1 | Bos taurus | S138 | TVVPASIAIPM | 1 | Mus musculus | S145 | ATPVPSVKPEY | 1 | Homo sapiens | S145 | AIPVPGLKPEY | 1 | Bos taurus | S145 | AIPMPSVKPEY | 1 | Mus musculus | S205 | VIGTCSSDEKS | 1 | Homo sapiens | S205 | VIGTCSSAEKS | 1 | Bos taurus | S205 | VIGTCSSDEKA | 1 | Mus musculus | S247 | DVVYESVGGAM | 3 | Homo sapiens, Bos taurus, Mus musculus | S273 | VIGFISGYQTP | 1 | Homo sapiens | S273 | VIGFVSGYQTP | 1 | Bos taurus | S273 | VIGFISGYQSP | 1 | Mus musculus | S77 | VGVNASDINYS | 2 | Homo sapiens, Bos taurus | S77 | VGINASDINYS | 1 | Mus musculus | T159 | LVSGTTAYISL | 2 | Homo sapiens, Bos taurus | T159 | LVSGTTAYLSL | 1 | Mus musculus | T185 | AAAGGTGQFAV | 2 | Bos taurus, Mus musculus | T185 | AAAGGTGQFAM | 1 | Homo sapiens | T279 | GYQTPTGLSPV | 2 | Homo sapiens, Bos taurus | T279 | GYQSPTGLSPI | 1 | Mus musculus | V155 | YLTLLVSGTTA | 2 | Homo sapiens, Bos taurus | V155 | YLTMLVSGTTA | 1 | Mus musculus | V248 | VVYESVGGAMF | 3 | Homo sapiens, Bos taurus, Mus musculus | Y150 | SVKPEYLTLLV | 1 | Homo sapiens | Y150 | GLKPEYLTLLV | 1 | Bos taurus | Y150 | SVKPEYLTMLV | 1 | Mus musculus | Y161 | SGTTAYISLKE | 2 | Homo sapiens, Bos taurus | Y161 | SGTTAYLSLEE | 1 | Mus musculus | Y224 | DRPINYKTEPV | 1 | Homo sapiens | Y224 | DRPINYNTEHV | 1 | Bos taurus | Y224 | DRPINYRTEPV | 1 | Mus musculus | Y275 | GFISGYQTPTG | 1 | Homo sapiens | Y275 | GFVSGYQTPTG | 1 | Bos taurus | Y275 | GFISGYQSPTG | 1 | Mus musculus | Y312 | HYLSKYQAAMS | 1 | Homo sapiens | Y312 | HYLPEFRGAMD | 1 | Bos taurus | Y312 | HYFSKYQAAME | 1 | Mus musculus | Y86 | YSAGRYDPSVK | 2 | Homo sapiens, Bos taurus | Y86 | YSAGRYDPSLK | 1 | Mus musculus |
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