mutLBSgeneDB |
Gene summary for NSMCE2 |
![]() |
Basic gene Info. | Gene symbol | NSMCE2 |
Gene name | non-SMC element 2, MMS21 homolog (S. cerevisiae) | |
Synonyms | C8orf36|MMS21|NSE2|ZMIZ7 | |
Cytomap | UCSC genome browser: 8q24.13 | |
Type of gene | protein-coding | |
RefGenes | NM_173685.2, | |
Description | E3 SUMO-protein ligase NSE2MMS21 homologhMMS21methyl methanesulfonate sensitivity gene 21non-SMC element 2 homolognon-structural maintenance of chromosomes element 2 homologzinc finger, MIZ-type containing 7 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000156831 | ||
HPRD : 08131 | ||
Vega : OTTHUMG00000164993 | ||
Protein | UniProt: Q96MF7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NSMCE2 | |
BioGPS: 286053 | ||
Pathway | NCI Pathway Interaction Database: NSMCE2 | |
KEGG: NSMCE2 | ||
REACTOME: NSMCE2 | ||
Pathway Commons: NSMCE2 | ||
Context | iHOP: NSMCE2 | |
ligand binding site mutation search in PubMed: NSMCE2 | ||
UCL Cancer Institute: NSMCE2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for NSMCE2 |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | H187 | T188S | OV | 1 | C185,H187 | G186C | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for NSMCE2 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H187 | T188S | -0.78132545 | H187 | G186C | -0.68852798 | C185 | G186C | -0.68852798 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for NSMCE2 |
![]() |
![]() |
Top |
Top |
Phenotype information for NSMCE2 |
![]() |
Disease ID | Disease name | # PubMed | Association type |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for NSMCE2 |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of NSMCE2 |
![]() |
LBS | AA sequence | # species | Species | C185 | VKNKVCGHTYE | 2 | Homo sapiens, Bos taurus | C185 | VKNKMCGHTYE | 2 | Mus musculus, Rattus norvegicus | C210 | KKKACCPKIGC | 3 | Bos taurus, Mus musculus, Rattus norvegicus | C210 | KKKAYCPQIGC | 1 | Homo sapiens | C215 | CPKIGCSHTDM | 2 | Mus musculus, Rattus norvegicus | C215 | CPQIGCSHTDI | 1 | Homo sapiens | C215 | CPKIGCSHVDM | 1 | Bos taurus | H187 | NKMCGHTYEEE | 2 | Mus musculus, Rattus norvegicus | H187 | NKVCGHTYEED | 1 | Homo sapiens | H187 | NKVCGHTYEEE | 1 | Bos taurus |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |