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mutLBSgeneDB |
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| Gene summary for MKNK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | MKNK2 |
| Gene name | MAP kinase interacting serine/threonine kinase 2 | |
| Synonyms | GPRK7|MNK2 | |
| Cytomap | UCSC genome browser: 19p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017572.3, NM_199054.2, | |
| Description | G protein-coupled receptor kinase 7MAP kinase signal-integrating kinase 2MAP kinase-interacting serine/threonine-protein kinase 2MAPK signal-integrating kinase 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605069 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000099875 | ||
| HPRD : 05459 | ||
| Vega : OTTHUMG00000180020 | ||
| Protein | UniProt: Q9HBH9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MKNK2 | |
| BioGPS: 2872 | ||
| Pathway | NCI Pathway Interaction Database: MKNK2 | |
| KEGG: MKNK2 | ||
| REACTOME: MKNK2 | ||
| Pathway Commons: MKNK2 | ||
| Context | iHOP: MKNK2 | |
| ligand binding site mutation search in PubMed: MKNK2 | ||
| UCL Cancer Institute: MKNK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 11463832 | GO:0030097 | hemopoiesis | 21149447 | GO:0035556 | intracellular signal transduction | 11463832 | GO:0071243 | cellular response to arsenic-containing substance | 18299328 |
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| Ligand binding site mutations for MKNK2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F159 | L157Q | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MKNK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F159 | L157Q | -1.323166 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MKNK2 from PDB |
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| Differential gene expression and gene-gene network for MKNK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MKNK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MKNK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MKNK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | STU | STAUROSPORINE | 2hw7 | A | F159 |
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| Conservation information for LBS of MKNK2 |
| Multiple alignments for Q9HBH9 in multiple species |
| LBS | AA sequence | # species | Species | A111 | TSQEYAVKIIE | 1 | Homo sapiens | A111 | TNKEYAVKIIE | 1 | Xenopus tropicalis | A111 | TNQEYAVKIIE | 1 | Rattus norvegicus | C299 | PFVGHCGSDCG | 2 | Xenopus tropicalis, Rattus norvegicus | C299 | PFVGRCGSDCG | 1 | Homo sapiens | C311 | DRGEACPACQN | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | C314 | EACPACQNMLF | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | E160 | FYLVFEKMRGG | 2 | Homo sapiens, Rattus norvegicus | E160 | FYLVFEKMCGG | 1 | Xenopus tropicalis | E209 | RDLKPENILCE | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | E92 | EDVLGEGAHAR | 2 | Homo sapiens, Rattus norvegicus | E92 | QEILGEGAYAK | 1 | Xenopus tropicalis | F159 | RFYLVFEKMRG | 2 | Homo sapiens, Rattus norvegicus | F159 | KFYLVFEKMCG | 1 | Xenopus tropicalis | G165 | EKMRGGSILSH | 2 | Homo sapiens, Rattus norvegicus | G165 | EKMCGGSILNH | 1 | Xenopus tropicalis | G91 | QEDVLGEGAHA | 2 | Homo sapiens, Rattus norvegicus | G91 | QQEILGEGAYA | 1 | Xenopus tropicalis | K113 | QEYAVKIIEKQ | 2 | Homo sapiens, Rattus norvegicus | K113 | KEYAVKIIEKR | 1 | Xenopus tropicalis | K161 | YLVFEKMRGGS | 2 | Homo sapiens, Rattus norvegicus | K161 | YLVFEKMCGGS | 1 | Xenopus tropicalis | L143 | GHRNVLELIEF | 2 | Homo sapiens, Rattus norvegicus | L143 | GHSNVLELIEF | 1 | Xenopus tropicalis | L212 | KPENILCEHPN | 2 | Homo sapiens, Rattus norvegicus | L212 | KPENILCESPH | 1 | Xenopus tropicalis | L90 | LQEDVLGEGAH | 2 | Homo sapiens, Rattus norvegicus | L90 | LQQEILGEGAY | 1 | Xenopus tropicalis | M162 | LVFEKMRGGSI | 2 | Homo sapiens, Rattus norvegicus | M162 | LVFEKMCGGSI | 1 | Xenopus tropicalis |
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