mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GRB2
Gene summary
Basic gene Info.Gene symbolGRB2
Gene namegrowth factor receptor-bound protein 2
SynonymsASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2
CytomapUCSC genome browser: 17q24-q25
Type of geneprotein-coding
RefGenesNM_002086.4,
NM_203506.2,
DescriptionHT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ash
Modification date20141222
dbXrefs MIM : 108355
HGNC : HGNC
Ensembl : ENSG00000177885
HPRD : 00150
Vega : OTTHUMG00000134332
ProteinUniProt: P62993
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GRB2
BioGPS: 2885
PathwayNCI Pathway Interaction Database: GRB2
KEGG: GRB2
REACTOME: GRB2
Pathway Commons: GRB2
ContextiHOP: GRB2
ligand binding site mutation search in PubMed: GRB2
UCL Cancer Institute: GRB2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for GRB2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F9F9LCOAD6
H79G81VCOAD1
A115,K117G116RCOAD1
S127S127YCOAD1
E152V154LLUAD1
Y52I53RLUAD1
E152I151MLUAD1
E130E130DOV1
F9F9LOV1
R67P66TSKCM1
W121W121CSTAD1
F9Y7DSTAD1
K117K117RUCEC1
H79D80NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GRB2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E152I151M-1.1049148
Y52I53R-1.095534
F9F9L-1.069003
E130E130D-1.051599
R67P66T-0.94519696
W121W121C-0.82456024
F9Y7D-0.80217414
H79D80N-0.71987968
K117K117R-0.49003067
E152V154L-0.48732416
S127S127Y-0.46107843
H79G81V-0.24435141
K117G116R-0.095163392
A115G116R-0.095163392
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GRB2 from PDB
PDB IDPDB titlePDB structure
1CJ1GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

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Differential gene expression and gene-gene network for GRB2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GRB2 and the right PPI network was created from samples without mutations in the LBS of GRB2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GRB2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GRB2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00061Pegademase bovineBiotech
ExperimentalDB032764-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GRB2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobAA115 K117
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobCA115 K117
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobCA115 K117
IIIPeptide ligand (ARG,HIS,TYR,ARG,PRO,LEU,PRO,PRO,LEU,PRO)1io6AF9
IIIPeptide ligand (ALA,PRO,PRO,PRO,ARG,PRO,PRO,LYS,PRO)2w0zAF9
IIIPeptide ligand (VAL,PRO,PRO,PRO,VAL,PRO,PRO,ARG,ARG,ARG)1azeAF9 Y52
ZNZINC(2+)1zfpEH79 E152
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aoaAK117
IIIPeptide ligand (ACE,TYR,VAL,ASN,VAL)1fyrDR67
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aoaAR67
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobAR67
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobCR67
IIIPeptide ligand (ACE,TYR,VAL,ASN,NH2)2h5kAR67
IIIPeptide ligand (ACE,LYS,TYR,VAL,ASN,VAL,PRO)1bm2AR67 W121
IIIPeptide ligand (LYS,PRO,PHE,TYR,VAL,ASN,VAL,GLU,PHE)1bmbAR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1AR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1BR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1CR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1DR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1ER67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1FR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1GR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1HR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1IR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1JR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1KR67 W121
C78[1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)-ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER1cj1LR67 W121
IIIPeptide ligand (ACE,TYR,VAL,ASN,VAL)1fyrAR67 W121
IIIPeptide ligand (ACE,TYR,VAL,ASN,VAL)1fyrBR67 W121
IIIPeptide ligand (ACE,TYR,VAL,ASN,VAL)1fyrCR67 W121
IIIPeptide ligand (MAZ,TYR,TYR,ASN)1jyqAR67 W121
IIIPeptide ligand (MAZ,TYR,TYR,ASN)1jyqBR67 W121
IIIPeptide ligand (ALA,PRO,SER,TYR,VAL,ASN,VAL,GLN,ASN)1jyrAR67 W121
IIIPeptide ligand (LYS,PRO,PHE,TYR,VAL,ASN,VAL,NH2)1tzeER67 W121
DTF4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONICACID1x0nAR67 W121
IIIPeptide ligand (BE2,GLU,TYR,ILE,ASN,GLN,NH2)1zfpER67 W121
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobBR67 W121
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobDR67 W121
YVNN-({(1R,2R,3S)-2-(METHYLCARBAMOYL)-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE2huwAR67 W121
YVNN-({(1R,2R,3S)-2-(METHYLCARBAMOYL)-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE2huwBR67 W121
TVNN-{(2R)-4-(METHYLAMINO)-4-OXO-2-[4-(PHOSPHONOOXY)BENZYL]BUTANOYL}-L-VALYL-L-ASPARTAMIDE3c7iAR67 W121
FYQN~2~-{(2R)-4-(METHYLAMINO)-4-OXO-2-[4-(PHOSPHONOOXY)BENZYL]BUTANOYL}-L-GLUTAMINYL-L-ASPARTAMIDE3imdAR67 W121
FYQN~2~-{(2R)-4-(METHYLAMINO)-4-OXO-2-[4-(PHOSPHONOOXY)BENZYL]BUTANOYL}-L-GLUTAMINYL-L-ASPARTAMIDE3imdBR67 W121
AYI(1R,2S,3R,1S',1S")PHOSPHORIC ACID MONO(4-{2-[1-(1,2-DICARBAMOYLETHYLCARBAMOYL)-3-CARBAMOYLPROPYLCARBAMOYL]-3-METHYLCARBAMOYLCYCLOPROPYL}PHENYL) ESTER3imjAR67 W121
AYI(1R,2S,3R,1S',1S")PHOSPHORIC ACID MONO(4-{2-[1-(1,2-DICARBAMOYLETHYLCARBAMOYL)-3-CARBAMOYLPROPYLCARBAMOYL]-3-METHYLCARBAMOYLCYCLOPROPYL}PHENYL) ESTER3imjBR67 W121
AYQN~2~-({(1R,2R,3S)-2-(METHYLCARBAMOYL)-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-D-GLUTAMINYL-D-ASPARTAMIDE3in7AR67 W121
AYQN~2~-({(1R,2R,3S)-2-(METHYLCARBAMOYL)-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-D-GLUTAMINYL-D-ASPARTAMIDE3in7CR67 W121
FYIN-{(2S)-4-(METHYLAMINO)-4-OXO-2-[4-(PHOSPHONOOXY)BENZYL]BUTANOYL}-L-ISOLEUCYL-L-ASPARTAMIDE3in8AR67 W121
YENN-{(2S)-4-(METHYLAMINO)-4-OXO-2-[4-(PHOSPHONOOXY)BENZYL]BUTANOYL}-L-ALPHA-GLUTAMYL-L-ASPARTAMIDE3kfjAR67 W121
IIIPeptide ligand (GLY,TYR,GLU,ASN,PRO,THR,TYR)3mxcAR67 W121
IIIPeptide ligand (GLY,TYR,VAL,ASN,PRO,THR,TYR)3mxyAR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,011)3n7yAR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,011)3n7yBR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,011)3n7yCR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,PRO,011)3n84AR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,PRO,011)3n84BR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,PRO,011)3n84CR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,PRO,011)3n84DR67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,PRO,011)3n84ER67 W121
IIIPeptide ligand (TYR,VAL,ASN,VAL,PRO,011)3n84FR67 W121
IIIPeptide ligand (6NA,TYR,VAL,ASN,VAL,9PR)3n8mAR67 W121
IIIPeptide ligand (ACT,TYR,ALA,ASN,NH2)3ov1AR67 W121
IIIPeptide ligand (ACT,TYR,03E,ASN,NH2)3oveAR67 W121
IIIPeptide ligand (ACE,TYR,192,ASN,NH2)3s8lAR67 W121
IIIPeptide ligand (ACE,TYR,AC5,ASN,NH2)3s8nAR67 W121
IIIPeptide ligand (ACE,TYR,ALA,ASN,NH2)3s8oAR67 W121
IIIPeptide ligand (ASP,TYR,MET,ASN,MET,THR)3wa4AR67 W121
IIIPeptide ligand (PHQ,PTR,02K,ASN,NH2)4p9vAR67 W121
IIIPeptide ligand (NMI,PTR,02K,ASN,NH2)4p9zAR67 W121
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobBS127
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobBS127
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobDS127
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobDS127
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aoaBW121
MGMAGNESIUM(2+)3n84CW121
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aoaBW121 E130
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobBW121 E130
S1S2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2aobDW121 E130


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Conservation information for LBS of GRB2
Multiple alignments for P62993 in multiple species
LBSAA sequence# speciesSpecies
A115VLRDGAGKYFL4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
A115VLRDQNGKYYL1Caenorhabditis elegans
A115VLRDAQSKFFL1Drosophila melanogaster
A115VLRDGAGKYLL1Gallus gallus
D113FKVLRDGAGKY5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
D113FKVLRDQNGKY1Caenorhabditis elegans
D113FKVLRDAQSKF1Drosophila melanogaster
D133LNELVDYHRST5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
D133LNELVAYHRTA1Caenorhabditis elegans
D133LNELVEYHRTA1Drosophila melanogaster
D15KATADDELSFK5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
D15QAGSPDELSFK1Caenorhabditis elegans
D15SATADDELSFR1Drosophila melanogaster
D190VMDNSDPNWWK3Homo sapiens, Rattus norvegicus, Mus musculus
D190LINKDDPNWWE1Caenorhabditis elegans
D190VTDRSDENWWN1Drosophila melanogaster
D190VLDNSDPNWWK1Gallus gallus
D190VVDNSDPNWWK1Xenopus tropicalis
D33LNEECDQNWYK5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
D33LNKDEDPHWYK1Caenorhabditis elegans
D33LNMEDDSNWYR1Drosophila melanogaster
E130FNSLNELVDYH5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
E130FNSLNELVAYH1Caenorhabditis elegans
E130FNSLNELVEYH1Drosophila melanogaster
E152FLRDIEQVP--3Homo sapiens, Gallus gallus, Rattus norvegicus
E152LLSDMN-----1Caenorhabditis elegans
E152KLRDM--IP--1Drosophila melanogaster
E152FLRDIEQVPQV1Xenopus tropicalis
E152FLRDIEQMP--1Mus musculus
E16ATADDELSFKR5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
E16AGSPDELSFKR1Caenorhabditis elegans
E16ATADDELSFRK1Drosophila melanogaster
E171DFDPQEDGELG4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
E171DFNPQESGELA1Caenorhabditis elegans
E171DFVPQESGELD1Drosophila melanogaster
E171DFDPQEEGELG1Gallus gallus
E174PQEDGELGFRR4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
E174PQESGELAFKR1Caenorhabditis elegans
E174PQESGELDFRR1Drosophila melanogaster
E174PQEEGELGFRR1Gallus gallus
E87AFLIRESESAP5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
E87HFLVRQCESSP1Caenorhabditis elegans
E87AFLIRISESSP1Drosophila melanogaster
E89LIRESESAPGD5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
E89LVRQCESSPGE1Caenorhabditis elegans
E89LIRISESSPGD1Drosophila melanogaster
F101SLSVKFGNDVQ5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F101SISVRFQDSVQ1Caenorhabditis elegans
F101SLSVKCPDGVQ1Drosophila melanogaster
F108NDVQHFKVLRD4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F108DSVQHFKVLRD1Caenorhabditis elegans
F108DGVQHFKVLRD1Drosophila melanogaster
F108NDVQQFKVLRD1Gallus gallus
F125LWVVKFNSLNE6Homo sapiens, Drosophila melanogaster, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F125LWAVKFNSLNE1Caenorhabditis elegans
F147RNQQIFLRDIE5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F147RTHTILLSDMN1Caenorhabditis elegans
F147RSQDVKLRDM-1Drosophila melanogaster
F165YVQALFDFDPQ5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F165FVQALFDFNPQ1Caenorhabditis elegans
F165LVQALYDFVPQ1Drosophila melanogaster
F167QALFDFDPQED4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F167QALFDFNPQES1Caenorhabditis elegans
F167QALYDFVPQES1Drosophila melanogaster
F167QALFDFDPQEE1Gallus gallus
F61KPHPWFFGKIP5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F61TECNWYLGKIT1Caenorhabditis elegans
F61KNHDWYYGRIT1Drosophila melanogaster
F9IAKYDFKATAD4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
F9VAEHDFQAGSP1Caenorhabditis elegans
F9IAKHDFSATAD1Drosophila melanogaster
F9VAKYDFKATAD1Xenopus tropicalis
F95SAPGDFSLSVK5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
F95SSPGEFSISVR1Caenorhabditis elegans
F95SSPGDFSLSVK1Drosophila melanogaster
G93SESAPGDFSLS5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
G93CESSPGEFSIS1Caenorhabditis elegans
G93SESSPGDFSLS1Drosophila melanogaster
H107GNDVQHFKVLR4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
H107QDSVQHFKVLR1Caenorhabditis elegans
H107PDGVQHFKVLR1Drosophila melanogaster
H107GNDVQQFKVLR1Gallus gallus
H58IEMKPHPWFFG5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
H58IRMTECNWYLG1Caenorhabditis elegans
H58IEMKNHDWYYG1Drosophila melanogaster
H79SKQR-HDGAFL3Homo sapiens, Rattus norvegicus, Mus musculus
H79GKQR-HDGAFL2Gallus gallus, Xenopus tropicalis
H79KKPTVRDGHFL1Caenorhabditis elegans
H79SN-K-HEGAFL1Drosophila melanogaster
K109DVQHFKVLRDG4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
K109SVQHFKVLRDQ1Caenorhabditis elegans
K109GVQHFKVLRDA1Drosophila melanogaster
K109DVQQFKVLRDG1Gallus gallus
K117RDGAGKYFLWV4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
K117RDQNGKYYLWA1Caenorhabditis elegans
K117RDAQSKFFLWV1Drosophila melanogaster
K117RDGAGKYLLWV1Gallus gallus
K124FLWVVKFNSLN5Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Rattus norvegicus, Mus musculus
K124YLWAVKFNSLN1Caenorhabditis elegans
K124LLWVVKFNSLN1Gallus gallus
L111QHFKVLRDGAG4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
L111QHFKVLRDQNG1Caenorhabditis elegans
L111QHFKVLRDAQS1Drosophila melanogaster
L111QQFKVLRDGAG1Gallus gallus
L120AGKYFLWVVKF4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
L120NGKYYLWAVKF1Caenorhabditis elegans
L120QSKFFLWVVKF1Drosophila melanogaster
L120AGKYLLWVVKF1Gallus gallus
L128VKFNSLNELVD5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
L128VKFNSLNELVA1Caenorhabditis elegans
L128VKFNSLNELVE1Drosophila melanogaster
M204HGQTGMFPRNY4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
M204NNRRGIFPSNY1Caenorhabditis elegans
M204GNRKGIFPATY1Drosophila melanogaster
M204LGQTGMFPRNY1Xenopus tropicalis
N126WVVKFNSLNEL6Homo sapiens, Drosophila melanogaster, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
N126WAVKFNSLNEL1Caenorhabditis elegans
N129KFNSLNELVDY5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
N129KFNSLNELVAY1Caenorhabditis elegans
N129KFNSLNELVEY1Drosophila melanogaster
N143TSVSRNQQIFL5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
N143ASVSRTHTILL1Caenorhabditis elegans
N143ASVSRSQDVKL1Drosophila melanogaster
N192DNSDPNWWKGA4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
N192NKDDPNWWEGQ1Caenorhabditis elegans
N192DRSDENWWNGE1Drosophila melanogaster
N192DNSDPNWWKGT1Xenopus tropicalis
N208GMFPRNYVTPV5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
N208GIFPSNYVCPY1Caenorhabditis elegans
N208GIFPATYVTPY1Drosophila melanogaster
N35EECDQNWYKAE5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
N35KDEDPHWYKAE1Caenorhabditis elegans
N35MEDDSNWYRAE1Drosophila melanogaster
N51GFIPKNYIEMK5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
N51GFIPSNYIRMT1Caenorhabditis elegans
N51GLIPSNYIEMK1Drosophila melanogaster
P206QTGMFPRNYVT5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
P206RRGIFPSNYVC1Caenorhabditis elegans
P206RKGIFPATYVT1Drosophila melanogaster
P49KDGFIPKNYIE4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
P49NEGFIPSNYIR1Caenorhabditis elegans
P49KEGLIPSNYIE1Drosophila melanogaster
P49KGGFIPKNYIE1Gallus gallus
Q106FGNDVQHFKVL4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Q106FQDSVQHFKVL1Caenorhabditis elegans
Q106CPDGVQHFKVL1Drosophila melanogaster
Q106FGNDVQQFKVL1Gallus gallus
Q145VSRNQQIFLRD5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Q145VSRTHTILLSD1Caenorhabditis elegans
Q145VSRSQDVKLRD1Drosophila melanogaster
Q170FDFDPQEDGEL4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Q170FDFNPQESGEL1Caenorhabditis elegans
Q170YDFVPQESGEL1Drosophila melanogaster
Q170FDFDPQEEGEL1Gallus gallus
R142STSVSRNQQIF5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
R142TASVSRTHTIL1Caenorhabditis elegans
R142TASVSRSQDVK1Drosophila melanogaster
R207TGMFPRNYVTP5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
R207RGIFPSNYVCP1Caenorhabditis elegans
R207KGIFPATYVTP1Drosophila melanogaster
R67FGKIPRAKAEE5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
R67LGKITRNDAEV1Caenorhabditis elegans
R67YGRITRADAEK1Drosophila melanogaster
R86GAFLIRESESA5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
R86GHFLVRQCESS1Caenorhabditis elegans
R86GAFLIRISESS1Drosophila melanogaster
S127VVKFNSLNELV6Homo sapiens, Drosophila melanogaster, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
S127AVKFNSLNELV1Caenorhabditis elegans
S139YHRSTSVSRNQ5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
S139YHRTASVSRTH1Caenorhabditis elegans
S139YHRTASVSRSQ1Drosophila melanogaster
S141RSTSVSRNQQI5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
S141RTASVSRTHTI1Caenorhabditis elegans
S141RTASVSRSQDV1Drosophila melanogaster
S88FLIRESESAPG5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
S88FLVRQCESSPG1Caenorhabditis elegans
S88FLIRISESSPG1Drosophila melanogaster
S90IRESESAPGDF5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
S90VRQCESSPGEF1Caenorhabditis elegans
S90IRISESSPGDF1Drosophila melanogaster
S96APGDFSLSVKF5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
S96SPGEFSISVRF1Caenorhabditis elegans
S96SPGDFSLSVKC1Drosophila melanogaster
T138DYHRSTSVSRN5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
T138AYHRTASVSRT1Caenorhabditis elegans
T138EYHRTASVSRS1Drosophila melanogaster
V122KYFLWVVKFNS4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
V122KYYLWAVKFNS1Caenorhabditis elegans
V122KFFLWVVKFNS1Drosophila melanogaster
V122KYLLWVVKFNS1Gallus gallus
V123YFLWVVKFNSL4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
V123YYLWAVKFNSL1Caenorhabditis elegans
V123FFLWVVKFNSL1Drosophila melanogaster
V123YLLWVVKFNSL1Gallus gallus
W121GKYFLWVVKFN4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
W121GKYYLWAVKFN1Caenorhabditis elegans
W121SKFFLWVVKFN1Drosophila melanogaster
W121GKYLLWVVKFN1Gallus gallus
W193NSDPNWWKGAC4Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
W193KDDPNWWEGQL1Caenorhabditis elegans
W193RSDENWWNGEI1Drosophila melanogaster
W193NSDPNWWKGTC1Xenopus tropicalis
W36ECDQNWYKAEL5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
W36DEDPHWYKAEL1Caenorhabditis elegans
W36EDDSNWYRAEL1Drosophila melanogaster
W60MKPHPWFFGKI5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
W60MTECNWYLGKI1Caenorhabditis elegans
W60MKNHDWYYGRI1Drosophila melanogaster
Y118DGAGKYFLWVV4Homo sapiens, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Y118DQNGKYYLWAV1Caenorhabditis elegans
Y118DAQSKFFLWVV1Drosophila melanogaster
Y118DGAGKYLLWVV1Gallus gallus
Y134NELVDYHRSTS5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Y134NELVAYHRTAS1Caenorhabditis elegans
Y134NELVEYHRTAS1Drosophila melanogaster
Y209MFPRNYVTPVN5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Y209IFPSNYVCPYN1Caenorhabditis elegans
Y209IFPATYVTPYH1Drosophila melanogaster
Y52FIPKNYIEMKP5Homo sapiens, Gallus gallus, Xenopus tropicalis, Rattus norvegicus, Mus musculus
Y52FIPSNYIRMTE1Caenorhabditis elegans
Y52LIPSNYIEMKN1Drosophila melanogaster


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