mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ANPEP
Gene summary
Basic gene Info.Gene symbolANPEP
Gene namealanyl (membrane) aminopeptidase
CytomapUCSC genome browser: 15q25-q26
Type of geneprotein-coding
DescriptionAP-MAP-Nalanyl aminopeptidaseaminopeptidase Maminopeptidase NhAPNmicrosomal aminopeptidasemyeloid plasma membrane glycoprotein CD13
Modification date20141211
dbXrefs MIM : 151530
Ensembl : ENSG00000166825
HPRD : 01055
Vega : OTTHUMG00000149814
ProteinUniProt: P15144
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ANPEP
BioGPS: 290
PathwayNCI Pathway Interaction Database: ANPEP
Pathway Commons: ANPEP
ContextiHOP: ANPEP
ligand binding site mutation search in PubMed: ANPEP
UCL Cancer Institute: ANPEP
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ANPEP

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ANPEP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ANPEP from PDB

Differential gene expression and gene-gene network for ANPEP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ANPEP and the right PPI network was created from samples without mutations in the LBS of ANPEP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ANPEP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ANPEP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00973EzetimibeSmall molecule
ApprovedDB06196IcatibantSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ANPEP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4fyqAH388 H392 E411
ZNZINC(2+)4fyrAH388 H392 E411
ZNZINC(2+)4fytAH388 H392 E411
IIIPeptide ligand (VAL,TYR,ILE,HIS,PRO,PHE)4fysAQ211 Q213 M354 H388 E411
IIIPeptide ligand (L2O,VAL,VAL,ASP)4fytAQ211 Q213 M354 R363 H388 H392 E411

Conservation information for LBS of ANPEP
Multiple alignments for P15144 in multiple species
LBSAA sequence# speciesSpecies
A214TTQMQAADARK3Homo sapiens, Mus musculus, Rattus norvegicus
A214TTQMQAPDARK1Gallus gallus
A214TTQMQSTDARK1Bos taurus
A351LPDFNAGAMEN5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
A353DFNAGAMENWG5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E355NAGAMENWGLV5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E389TVIAHELAHQW5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E411DLWLNEGFASY5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F472QISELFDAISY1Homo sapiens
F472QISEVFDSIAY1Gallus gallus
F472QISEMFDTISY1Bos taurus
F472QIMELFDSITY1Mus musculus
F472QISELFDSITY1Rattus norvegicus
F896YGGGSFSFSNL2Homo sapiens, Bos taurus
F896YGGGSFSFANL2Mus musculus, Rattus norvegicus
F896YGGGSFSFSRL1Gallus gallus
G352PDFNAGAMENW5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G894NDYGGGSFSFS1Homo sapiens
G894GQYGGGSFSFS1Gallus gallus
G894EDYGGGSFSFS1Bos taurus
G894ENYGGGSFSFA1Mus musculus
G894EDYGGGSFSFA1Rattus norvegicus
H388VTVIAHELAHQ5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
H392AHELAHQWFGN5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
M354FNAGAMENWGL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
N900SFSFANLIQGV2Mus musculus, Rattus norvegicus
N900SFSFSNLIQAV1Homo sapiens
N900SFSFSRLISAV1Gallus gallus
N900SFSFSNLIQGV1Bos taurus
Q211VVATTQMQAAD3Homo sapiens, Mus musculus, Rattus norvegicus
Q211VVATTQMQAPD1Gallus gallus
Q211VLATTQMQSTD1Bos taurus
Q213ATTQMQAADAR3Homo sapiens, Mus musculus, Rattus norvegicus
Q213ATTQMQAPDAR1Gallus gallus
Q213ATTQMQSTDAR1Bos taurus
Q903FANLIQGVTRR2Mus musculus, Rattus norvegicus
Q903FSNLIQAVTRR1Homo sapiens
Q903FSRLISAVTQR1Gallus gallus
Q903FSNLIQGVTRR1Bos taurus
R363GLVTYRENSLL2Homo sapiens, Gallus gallus
R363GLVTYRENALL1Bos taurus
R363GLVTYRESSLV1Mus musculus
R363GLVTYRESALV1Rattus norvegicus
R381SSNKERVVTVI2Homo sapiens, Bos taurus
R381ISNKERVVTVI2Mus musculus, Rattus norvegicus
R381IGNKERVVTVI1Gallus gallus
R442LNDVYRVMAVD3Homo sapiens, Mus musculus, Rattus norvegicus
R442LNELYTVMATD1Gallus gallus
R442PNDVYSVMAVD1Bos taurus
R907IQGVTRRFSSE2Mus musculus, Rattus norvegicus
R907IQAVTRRFSTE1Homo sapiens
R907ISAVTQRFNTE1Gallus gallus
R907IQGVTRRFSTE1Bos taurus
S469TPAQISELFDA1Homo sapiens
S469TPAQISEVFDS1Gallus gallus
S469TPAQISEMFDT1Bos taurus
S469TPDQIMELFDS1Mus musculus
S469TPAQISELFDS1Rattus norvegicus
S895DYGGGSFSFSN2Homo sapiens, Bos taurus
S895QYGGGSFSFSR1Gallus gallus
S895NYGGGSFSFAN1Mus musculus
S895DYGGGSFSFAN1Rattus norvegicus
S897GGGSFSFSNLI2Homo sapiens, Bos taurus
S897GGGSFSFANLI2Mus musculus, Rattus norvegicus
S897GGGSFSFSRLI1Gallus gallus
V385ERVVTVIAHEL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y477FDSITYSKGAS2Mus musculus, Rattus norvegicus
Y477FDAISYSKGAS1Homo sapiens
Y477FDSIAYSKGAS1Gallus gallus
Y477FDTISYSKGAS1Bos taurus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas