mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZC3H7A
Gene summary
Basic gene Info.Gene symbolZC3H7A
Gene namezinc finger CCCH-type containing 7A
SynonymsZC3H7|ZC3HDC7
CytomapUCSC genome browser: 16p13-p12
Type of geneprotein-coding
RefGenesNM_014153.3,
Descriptionzinc finger CCCH domain-containing protein 7Azinc finger CCCH type domain containing 7zinc finger CCCH-type domain containing 7zinc-finger protein AY163807
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000122299
HPRD : 11694
Vega : OTTHUMG00000129825
ProteinUniProt: Q8IWR0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZC3H7A
BioGPS: 29066
PathwayNCI Pathway Interaction Database: ZC3H7A
KEGG: ZC3H7A
REACTOME: ZC3H7A
Pathway Commons: ZC3H7A
ContextiHOP: ZC3H7A
ligand binding site mutation search in PubMed: ZC3H7A
UCL Cancer Institute: ZC3H7A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ZC3H7A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C921K922TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ZC3H7A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C921K922T-0.89720225
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZC3H7A from PDB

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Differential gene expression and gene-gene network for ZC3H7A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZC3H7A and the right PPI network was created from samples without mutations in the LBS of ZC3H7A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ZC3H7A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ZC3H7A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZC3H7A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2d9mAC921


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Conservation information for LBS of ZC3H7A
Multiple alignments for Q8IWR0 in multiple species
LBSAA sequence# speciesSpecies


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