mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL15
Gene summary
Basic gene Info.Gene symbolMRPL15
Gene namemitochondrial ribosomal protein L15
SynonymsL15mt|MRP-L15|MRP-L7|RPML7
CytomapUCSC genome browser: 8q11.2-q13
Type of geneprotein-coding
RefGenesNM_014175.3,
Description39S ribosomal protein L15, mitochondrial
Modification date20141207
dbXrefs MIM : 611828
HGNC : HGNC
HPRD : 14742
ProteinUniProt: Q9P015
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL15
BioGPS: 29088
PathwayNCI Pathway Interaction Database: MRPL15
KEGG: MRPL15
REACTOME: MRPL15
Pathway Commons: MRPL15
ContextiHOP: MRPL15
ligand binding site mutation search in PubMed: MRPL15
UCL Cancer Institute: MRPL15
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL15

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C49C49YBRCA1
K34K34NCOAD1
H87E85VLUAD1
K48K48NSTAD1
R134R134MSTAD1
R77R77QUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL15
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H87E85V0.012736666
R77R77Q-1.0493196
R134R134M-0.87553058
K48K48N-0.48855453
K34K34N-0.29621894
C49C49Y-0.25695269
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL15 from PDB

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Differential gene expression and gene-gene network for MRPL15
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL15 and the right PPI network was created from samples without mutations in the LBS of MRPL15. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL15
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL15
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL15 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yMK34 K48 C49 R77 H87 R134


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Conservation information for LBS of MRPL15
Multiple alignments for Q9P015 in multiple species
LBSAA sequence# speciesSpecies
A25PRVSLANLKPN1Homo sapiens
A25PRITLANLRPN1Danio rerio
A25PKVSLANLRPN1Gallus gallus
A25PRVSLANLRPN1Bos taurus
A25PRVSLANLKPS1Mus musculus
C49RRGRKCGRGHK3Homo sapiens, Bos taurus, Mus musculus
C49HGGNRSGWGHK1Danio rerio
C49YRGRKCGRGHK1Gallus gallus
E37GSKKPERRP-R1Homo sapiens
E37GAKTLEKRRGR1Danio rerio
E37GSKKPERRRGR1Gallus gallus
E37GSRKPERRR-R1Bos taurus
E37NSRKRERRP-R1Mus musculus
E56RGHKGERQRGT3Homo sapiens, Bos taurus, Mus musculus
E56WGHKGERQRCN1Danio rerio
E56RGHKGERQRGN1Gallus gallus
E68PRLGFEGGQTP5Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus
F67RPRLGFEGGQT5Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus
F89NEGHSFRRQYK1Homo sapiens
F89NANHSRQPQYP1Danio rerio
F89NEGHSCRRKYH1Gallus gallus
F89NEGHSFRRQYQ1Bos taurus
F89NEGHSFRHQYQ1Mus musculus
G32LKPNPGSKKPE1Homo sapiens
G32LRPNPGAKTLE1Danio rerio
G32LRPNPGSKKPE1Gallus gallus
G32LRPNPGSRKPE1Bos taurus
G32LKPSPNSRKRE1Mus musculus
G42RRP-RGRRRGR1Homo sapiens
G42KRRGRGMHGGN1Danio rerio
G42RRRGRGRYRGR1Gallus gallus
G42RRR-RGQRRGR1Bos taurus
G42RRP-RDRRRGR1Mus musculus
G50RGRKCGRGHKG4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
G50GGNRSGWGHKG1Danio rerio
G52RKCGRGHKGER4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
G52NRSGWGHKGER1Danio rerio
G55GRGHKGERQRG4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
G55GWGHKGERQRC1Danio rerio
G69RLGFEGGQTPF5Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus
G70LGFEGGQTPFY5Homo sapiens, Danio rerio, Gallus gallus, Bos taurus, Mus musculus
H53KCGRGHKGERQ4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
H53RSGWGHKGERQ1Danio rerio
H87GFNEGHSFRRQ2Homo sapiens, Bos taurus
H87GYNANHSRQPQ1Danio rerio
H87GFNEGHSCRRK1Gallus gallus
H87GFNEGHSFRHQ1Mus musculus
I76QTPFYIRIPKY2Homo sapiens, Mus musculus
I76QTPFYLVIPKY1Danio rerio
I76QTPFYLSIPKY1Gallus gallus
I76QTPFYLRIPKY1Bos taurus
I78PFYIRIPKYGF2Homo sapiens, Mus musculus
I78PFYLVIPKYGY1Danio rerio
I78PFYLSIPKYGF1Gallus gallus
I78PFYLRIPKYGF1Bos taurus
K133TIQPLKRDYGV2Homo sapiens, Mus musculus
K133EIQPQKRDYGV1Danio rerio
K133TVQPLKRDYGV1Gallus gallus
K133TIQPSKRDYGV1Bos taurus
K28SLANLRPNPGS2Gallus gallus, Bos taurus
K28SLANLKPNPGS1Homo sapiens
K28TLANLRPNPGA1Danio rerio
K28SLANLKPSPNS1Mus musculus
K34PNPGSKKPERR2Homo sapiens, Gallus gallus
K34PNPGAKTLEKR1Danio rerio
K34PNPGSRKPERR1Bos taurus
K34PSPNSRKRERR1Mus musculus
K35NPGSKKPERRP1Homo sapiens
K35NPGAKTLEKRR1Danio rerio
K35NPGSKKPERRR1Gallus gallus
K35NPGSRKPERRR1Bos taurus
K35SPNSRKRERRP1Mus musculus
K48RRRGRKCGRGH2Homo sapiens, Mus musculus
K48MHGGNRSGWGH1Danio rerio
K48RYRGRKCGRGH1Gallus gallus
K48QRRGRKCGRGH1Bos taurus
K54CGRGHKGERQR4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
K54SGWGHKGERQR1Danio rerio
K80YIRIPKYGFNE2Homo sapiens, Mus musculus
K80YLVIPKYGYNA1Danio rerio
K80YLSIPKYGFNE1Gallus gallus
K80YLRIPKYGFNE1Bos taurus
L132VTIQPLKRDYG2Homo sapiens, Mus musculus
L132VEIQPQKRDYG1Danio rerio
L132VTVQPLKRDYG1Gallus gallus
L132VTIQPSKRDYG1Bos taurus
L24LPRVSLANLKP2Homo sapiens, Mus musculus
L24LPRITLANLRP1Danio rerio
L24LPKVSLANLRP1Gallus gallus
L24LPRVSLANLRP1Bos taurus
L27VSLANLRPNPG2Gallus gallus, Bos taurus
L27VSLANLKPNPG1Homo sapiens
L27ITLANLRPNPG1Danio rerio
L27VSLANLKPSPN1Mus musculus
N26RVSLANLKPNP1Homo sapiens
N26RITLANLRPNP1Danio rerio
N26KVSLANLRPNP1Gallus gallus
N26RVSLANLRPNP1Bos taurus
N26RVSLANLKPSP1Mus musculus
N30ANLKPNPGSKK1Homo sapiens
N30ANLRPNPGAKT1Danio rerio
N30ANLRPNPGSKK1Gallus gallus
N30ANLRPNPGSRK1Bos taurus
N30ANLKPSPNSRK1Mus musculus
P192LCKPIPFFLRG2Bos taurus, Mus musculus
P192VCKPVPFFLRG1Homo sapiens
P192LIKPVPFFMPG1Danio rerio
P192LIRPVPFFLRG1Gallus gallus
P29LANLKPNPGSK1Homo sapiens
P29LANLRPNPGAK1Danio rerio
P29LANLRPNPGSK1Gallus gallus
P29LANLRPNPGSR1Bos taurus
P29LANLKPSPNSR1Mus musculus
P36PGSKKPERRP-1Homo sapiens
P36PGAKTLEKRRG1Danio rerio
P36PGSKKPERRRG1Gallus gallus
P36PGSRKPERRR-1Bos taurus
P36PNSRKRERRP-1Mus musculus
P79FYIRIPKYGFN2Homo sapiens, Mus musculus
P79FYLVIPKYGYN1Danio rerio
P79FYLSIPKYGFN1Gallus gallus
P79FYLRIPKYGFN1Bos taurus
Q130RGVTIQPLKRD2Homo sapiens, Mus musculus
Q130RGVEIQPQKRD1Danio rerio
Q130RGVTVQPLKRD1Gallus gallus
Q130RGVTIQPSKRD1Bos taurus
Q198FFLRGQPIPKR4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
Q198FFMPGEPIPKR1Danio rerio
Q58HKGERQRGTRP3Homo sapiens, Bos taurus, Mus musculus
Q58HKGERQRCNRP1Danio rerio
Q58HKGERQRGNRP1Gallus gallus
Q71GFEGGQTPFYL3Danio rerio, Gallus gallus, Bos taurus
Q71GFEGGQTPFYI2Homo sapiens, Mus musculus
R100PLSLNRLQYLI2Homo sapiens, Bos taurus
R100PLSLRRLQYLI2Danio rerio, Mus musculus
R100PLSLQKLQYLI1Gallus gallus
R109LIDLGRVDPTQ3Gallus gallus, Bos taurus, Mus musculus
R109LIDLGRVDPSQ1Homo sapiens
R109LIDLGRIDPSQ1Danio rerio
R134IQPLKRDYGVQ2Homo sapiens, Mus musculus
R134IQPQKRDYGVQ1Danio rerio
R134VQPLKRDYGVQ1Gallus gallus
R134IQPSKRDYGVQ1Bos taurus
R196VPFFLRGQPIP2Homo sapiens, Gallus gallus
R196IPFFLRGQPIP2Bos taurus, Mus musculus
R196VPFFMPGEPIP1Danio rerio
R38SKKPERRP-RG1Homo sapiens
R38AKTLEKRRGRG1Danio rerio
R38SKKPERRRGRG1Gallus gallus
R38SRKPERRR-RG1Bos taurus
R38SRKRERRP-RD1Mus musculus
R39KKPERRP-RGR1Homo sapiens
R39KTLEKRRGRGM1Danio rerio
R39KKPERRRGRGR1Gallus gallus
R39RKPERRR-RGQ1Bos taurus
R39RKRERRP-RDR1Mus musculus
R41ERRP-RGRRRG1Homo sapiens
R41EKRRGRGMHGG1Danio rerio
R41ERRRGRGRYRG1Gallus gallus
R41ERRR-RGQRRG1Bos taurus
R41ERRP-RDRRRG1Mus musculus
R43RP-RGRRRGRK1Homo sapiens
R43RRGRGMHGGNR1Danio rerio
R43RRGRGRYRGRK1Gallus gallus
R43RR-RGQRRGRK1Bos taurus
R43RP-RDRRRGRK1Mus musculus
R44P-RGRRRGRKC1Homo sapiens
R44RGRGMHGGNRS1Danio rerio
R44RGRGRYRGRKC1Gallus gallus
R44R-RGQRRGRKC1Bos taurus
R44P-RDRRRGRKC1Mus musculus
R45-RGRRRGRKCG1Homo sapiens
R45GRGMHGGNRSG1Danio rerio
R45GRGRYRGRKCG1Gallus gallus
R45-RGQRRGRKCG1Bos taurus
R45-RDRRRGRKCG1Mus musculus
R47GRRRGRKCGRG1Homo sapiens
R47GMHGGNRSGWG1Danio rerio
R47GRYRGRKCGRG1Gallus gallus
R47GQRRGRKCGRG1Bos taurus
R47DRRRGRKCGRG1Mus musculus
R51GRKCGRGHKGE4Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
R51GNRSGWGHKGE1Danio rerio
R57GHKGERQRGTR3Homo sapiens, Bos taurus, Mus musculus
R57GHKGERQRCNR1Danio rerio
R57GHKGERQRGNR1Gallus gallus
R59KGERQRGTRPR3Homo sapiens, Bos taurus, Mus musculus
R59KGERQRCNRPR1Danio rerio
R59KGERQRGNRPR1Gallus gallus
R62RQRGTRPRLGF3Homo sapiens, Bos taurus, Mus musculus
R62RQRCNRPRLGF1Danio rerio
R62RQRGNRPRLGF1Gallus gallus
R64RGTRPRLGFEG3Homo sapiens, Bos taurus, Mus musculus
R64RCNRPRLGFEG1Danio rerio
R64RGNRPRLGFEG1Gallus gallus
R77TPFYIRIPKYG2Homo sapiens, Mus musculus
R77TPFYLVIPKYG1Danio rerio
R77TPFYLSIPKYG1Gallus gallus
R77TPFYLRIPKYG1Bos taurus
S33KPNPGSKKPER1Homo sapiens
S33RPNPGAKTLEK1Danio rerio
S33RPNPGSKKPER1Gallus gallus
S33RPNPGSRKPER1Bos taurus
S33KPSPNSRKRER1Mus musculus
S88FNEGHSFRRQY2Homo sapiens, Bos taurus
S88YNANHSRQPQY1Danio rerio
S88FNEGHSCRRKY1Gallus gallus
S88FNEGHSFRHQY1Mus musculus
T128NGRGVTIQPLK2Homo sapiens, Mus musculus
T128NGRGVEIQPQK1Danio rerio
T128NARGVTVQPLK1Gallus gallus
T128NGRGVTIQPSK1Bos taurus
T61ERQRGTRPRLG3Homo sapiens, Bos taurus, Mus musculus
T61ERQRCNRPRLG1Danio rerio
T61ERQRGNRPRLG1Gallus gallus
T72FEGGQTPFYIR2Homo sapiens, Mus musculus
T72FEGGQTPFYLV1Danio rerio
T72FEGGQTPFYLS1Gallus gallus
T72FEGGQTPFYLR1Bos taurus
Y103LNRLQYLIDLG2Homo sapiens, Bos taurus
Y103LRRLQYLIDLG2Danio rerio, Mus musculus
Y103LQKLQYLIDLG1Gallus gallus
Y75GQTPFYIRIPK2Homo sapiens, Mus musculus
Y75GQTPFYLVIPK1Danio rerio
Y75GQTPFYLSIPK1Gallus gallus
Y75GQTPFYLRIPK1Bos taurus


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