mutLBSgeneDB |
Gene summary for GRM1 |
Gene summary |
Basic gene Info. | Gene symbol | GRM1 |
Gene name | glutamate receptor, metabotropic 1 | |
Synonyms | GPRC1A|MGLU1|MGLUR1|PPP1R85|SCAR13 | |
Cytomap | UCSC genome browser: 6q24 | |
Type of gene | protein-coding | |
RefGenes | NM_001278064.1, NM_001278065.1,NM_001278066.1,NM_001278067.1,NM_000838.3, NM_001114329.1, | |
Description | metabotropic glutamate receptor 1protein phosphatase 1, regulatory subunit 85 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604473 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152822 | ||
HPRD : 05129 | ||
Vega : OTTHUMG00000015752 | ||
Protein | UniProt: Q13255 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GRM1 | |
BioGPS: 2911 | ||
Pathway | NCI Pathway Interaction Database: GRM1 | |
KEGG: GRM1 | ||
REACTOME: GRM1 | ||
Pathway Commons: GRM1 | ||
Context | iHOP: GRM1 | |
ligand binding site mutation search in PubMed: GRM1 | ||
UCL Cancer Institute: GRM1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0007186 | G-protein coupled receptor signaling pathway | 24603153 | GO:0038042 | dimeric G-protein coupled receptor signaling pathway | 24603153 |
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Ligand binding site mutations for GRM1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | F801 | A800D | BLCA | 1 | T655 | T655N | COAD | 1 | T655 | T655I | COAD | 1 | R661 | R661H | COAD | 1 | A818 | V819L | COAD | 1 | W798 | L799I | COAD | 1 | W798 | W798C | COAD | 1 | S189 | D191V | HNSC | 1 | L757 | G758C | LUAD | 1 | I604,L602 | G603R | LUAD | 1 | Y805,F801 | P803S | LUAD | 1 | T748 | T748N | LUAD | 1 | S189 | D191Y | LUAD | 1 | P756 | P756S | LUAD | 1 | G163 | G161C | LUAD | 1 | W798 | L799Q | LUSC | 1 | T653 | T653A | STAD | 1 | Y236 | G234V | STAD | 1 | L757 | G758S | STAD | 1 | S189 | S189N | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for GRM1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | I604 | G603R | 0.02844729 | L602 | G603R | 0.02844729 | P756 | P756S | -1.6043638 | W798 | L799Q | -1.4380604 | W798 | W798C | -1.3026943 | T655 | T655N | -1.1478182 | L757 | G758S | -1.1199929 | W798 | L799I | -1.0873369 | R661 | R661H | -1.0021833 | F801 | A800D | -0.98026925 | L757 | G758C | -0.94749873 | T653 | T653A | -0.91891535 | S189 | D191Y | -0.87442222 | S189 | D191V | -0.8461313 | G163 | G161C | -0.77878147 | T748 | T748N | -0.68436327 | Y236 | G234V | -0.66503349 | T655 | T655I | -0.56590647 | A818 | V819L | -0.48515689 | Y805 | P803S | -0.40443168 | F801 | P803S | -0.40443168 | S189 | S189N | -0.14814995 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for GRM1 from PDB |
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Differential gene expression and gene-gene network for GRM1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for GRM1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0014556 | Epilepsy, Temporal Lobe | 3 | Biomarker |
umls:C0038220 | Status Epilepticus | 2 | Biomarker |
umls:C1263846 | Attention Deficit Disorder with Hyperactivity | 1 | Biomarker |
umls:C0014544 | Epilepsy | 1 | Biomarker |
umls:C0016045 | Fibroma | 1 | Biomarker |
umls:C0206639 | Neoplasms, Bone Tissue | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for GRM1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Nutraceutical | DB00142 | L-Glutamic Acid | Small molecule | |
Experimental | DB04256 | 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of GRM1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | Z99 | (1S,2S)-2-[(2S)-2-AMINO-1-HYDROXY-1-OXO-3-(9H-XANTHEN-9-YL)PROPAN-2-YL]CYCLOPROPANE-1-CARBOXYLIC ACID | 3ks9 | A | G163 S189 Y236 | Z99 | (1S,2S)-2-[(2S)-2-AMINO-1-HYDROXY-1-OXO-3-(9H-XANTHEN-9-YL)PROPAN-2-YL]CYCLOPROPANE-1-CARBOXYLIC ACID | 3ks9 | B | G163 S189 Y236 | CLR | CHOLESTEROL | 4or2 | A | I604 | CLR | CHOLESTEROL | 4or2 | A | I604 | CLR | CHOLESTEROL | 4or2 | A | L602 | CLR | CHOLESTEROL | 4or2 | B | L602 | FM9 | 4-FLUORO-N-METHYL-N-{4-[6-(PROPAN-2-YLAMINO)PYRIMIDIN- 4-YL]-1,3-THIAZOL-2-YL}BENZAMIDE | 4or2 | A | R661 P756 L757 W798 F801 Y805 A818 | CLR | CHOLESTEROL | 4or2 | B | T653 T655 | CLR | CHOLESTEROL | 4or2 | A | T655 | FM9 | 4-FLUORO-N-METHYL-N-{4-[6-(PROPAN-2-YLAMINO)PYRIMIDIN- 4-YL]-1,3-THIAZOL-2-YL}BENZAMIDE | 4or2 | B | T748 P756 L757 W798 F801 Y805 A818 |
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Conservation information for LBS of GRM1 |
Multiple alignments for Q13255 in multiple species |
LBS | AA sequence | # species | Species | A187 | QIAYSATSIDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A598 | SIIAIAFSCLG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A650 | PFTLIAKPTTT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A818 | ITTCFAVSLSV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C601 | AIAFSCLGILV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F639 | ILAGIFLGYVC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F646 | GYVCPFTLIAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F801 | IIWLAFVPIYF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G163 | GVIGPGSSSVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G319 | LIGSDGWADRD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G665 | QRLLVGLSSAM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I594 | SDIESIIAIAF | 2 | Mus musculus, Rattus norvegicus | I594 | SNIESIIAIAF | 1 | Homo sapiens | I597 | ESIIAIAFSCL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I604 | FSCLGILVTLF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I764 | YNGLLIMSCTY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I797 | YTTCIIWLAFV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I812 | GSNYKIITTCF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K811 | FGSNYKIITTC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L602 | IAFSCLGILVT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L605 | SCLGILVTLFV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L648 | VCPFTLIAKPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L659 | TTSCYLQRLLV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L757 | GVVAPVGYNGL | 2 | Mus musculus, Rattus norvegicus | L757 | GVVAPLGYNGL | 1 | Homo sapiens | N760 | APVGYNGLLIM | 2 | Mus musculus, Rattus norvegicus | N760 | APLGYNGLLIM | 1 | Homo sapiens | P756 | LGVVAPVGYNG | 2 | Mus musculus, Rattus norvegicus | P756 | LGVVAPLGYNG | 1 | Homo sapiens | Q660 | TSCYLQRLLVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R661 | SCYLQRLLVGL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S164 | VIGPGSSSVAI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S165 | IGPGSSSVAIQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S186 | PQIAYSATSID | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S189 | AYSATSIDLSD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S668 | LVGLSSAMCYS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S822 | FAVSLSVTVAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T188 | IAYSATSIDLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T647 | YVCPFTLIAKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T653 | LIAKPTTTSCY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T655 | AKPTTTSCYLQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T748 | YLICNTSNLGV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T794 | FTMYTTCIIWL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T815 | YKIITTCFAVS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V643 | IFLGYVCPFTL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V664 | LQRLLVGLSSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V753 | TSNLGVVAPVG | 2 | Mus musculus, Rattus norvegicus | V753 | TSNLGVVAPLG | 1 | Homo sapiens | W110 | IRDSCWHSSVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W588 | VRYLEWSNIES | 1 | Homo sapiens | W588 | IRYLEWSDIES | 1 | Mus musculus | W588 | VRYLEWSDIES | 1 | Rattus norvegicus | W798 | TTCIIWLAFVP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y236 | HTEGNYGESGM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y74 | EIREQYGIQRV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y805 | AFVPIYFGSNY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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