mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GRM1
Gene summary
Basic gene Info.Gene symbolGRM1
Gene nameglutamate receptor, metabotropic 1
SynonymsGPRC1A|MGLU1|MGLUR1|PPP1R85|SCAR13
CytomapUCSC genome browser: 6q24
Type of geneprotein-coding
RefGenesNM_001278064.1,
NM_001278065.1,NM_001278066.1,NM_001278067.1,NM_000838.3,
NM_001114329.1,
Descriptionmetabotropic glutamate receptor 1protein phosphatase 1, regulatory subunit 85
Modification date20141207
dbXrefs MIM : 604473
HGNC : HGNC
Ensembl : ENSG00000152822
HPRD : 05129
Vega : OTTHUMG00000015752
ProteinUniProt: Q13255
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GRM1
BioGPS: 2911
PathwayNCI Pathway Interaction Database: GRM1
KEGG: GRM1
REACTOME: GRM1
Pathway Commons: GRM1
ContextiHOP: GRM1
ligand binding site mutation search in PubMed: GRM1
UCL Cancer Institute: GRM1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007186G-protein coupled receptor signaling pathway24603153
GO:0038042dimeric G-protein coupled receptor signaling pathway24603153


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Ligand binding site mutations for GRM1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F801A800DBLCA1
T655T655NCOAD1
T655T655ICOAD1
R661R661HCOAD1
A818V819LCOAD1
W798L799ICOAD1
W798W798CCOAD1
S189D191VHNSC1
L757G758CLUAD1
I604,L602G603RLUAD1
Y805,F801P803SLUAD1
T748T748NLUAD1
S189D191YLUAD1
P756P756SLUAD1
G163G161CLUAD1
W798L799QLUSC1
T653T653ASTAD1
Y236G234VSTAD1
L757G758SSTAD1
S189S189NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GRM1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I604G603R0.02844729
L602G603R0.02844729
P756P756S-1.6043638
W798L799Q-1.4380604
W798W798C-1.3026943
T655T655N-1.1478182
L757G758S-1.1199929
W798L799I-1.0873369
R661R661H-1.0021833
F801A800D-0.98026925
L757G758C-0.94749873
T653T653A-0.91891535
S189D191Y-0.87442222
S189D191V-0.8461313
G163G161C-0.77878147
T748T748N-0.68436327
Y236G234V-0.66503349
T655T655I-0.56590647
A818V819L-0.48515689
Y805P803S-0.40443168
F801P803S-0.40443168
S189S189N-0.14814995
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GRM1 from PDB

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Differential gene expression and gene-gene network for GRM1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GRM1 and the right PPI network was created from samples without mutations in the LBS of GRM1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GRM1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0014556Epilepsy, Temporal Lobe3Biomarker
umls:C0038220Status Epilepticus2Biomarker
umls:C1263846Attention Deficit Disorder with Hyperactivity1Biomarker
umls:C0014544Epilepsy1Biomarker
umls:C0016045Fibroma1Biomarker
umls:C0206639Neoplasms, Bone Tissue1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GRM1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00142L-Glutamic AcidSmall molecule
ExperimentalDB042564-(1-Amino-1-Carboxy-Ethyl)-Benzoic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GRM1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
Z99(1S,2S)-2-[(2S)-2-AMINO-1-HYDROXY-1-OXO-3-(9H-XANTHEN-9-YL)PROPAN-2-YL]CYCLOPROPANE-1-CARBOXYLIC ACID3ks9AG163 S189 Y236
Z99(1S,2S)-2-[(2S)-2-AMINO-1-HYDROXY-1-OXO-3-(9H-XANTHEN-9-YL)PROPAN-2-YL]CYCLOPROPANE-1-CARBOXYLIC ACID3ks9BG163 S189 Y236
CLRCHOLESTEROL4or2AI604
CLRCHOLESTEROL4or2AI604
CLRCHOLESTEROL4or2AL602
CLRCHOLESTEROL4or2BL602
FM94-FLUORO-N-METHYL-N-{4-[6-(PROPAN-2-YLAMINO)PYRIMIDIN- 4-YL]-1,3-THIAZOL-2-YL}BENZAMIDE4or2AR661 P756 L757 W798 F801 Y805 A818
CLRCHOLESTEROL4or2BT653 T655
CLRCHOLESTEROL4or2AT655
FM94-FLUORO-N-METHYL-N-{4-[6-(PROPAN-2-YLAMINO)PYRIMIDIN- 4-YL]-1,3-THIAZOL-2-YL}BENZAMIDE4or2BT748 P756 L757 W798 F801 Y805 A818


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Conservation information for LBS of GRM1
Multiple alignments for Q13255 in multiple species
LBSAA sequence# speciesSpecies
A187QIAYSATSIDL3Homo sapiens, Mus musculus, Rattus norvegicus
A598SIIAIAFSCLG3Homo sapiens, Mus musculus, Rattus norvegicus
A650PFTLIAKPTTT3Homo sapiens, Mus musculus, Rattus norvegicus
A818ITTCFAVSLSV3Homo sapiens, Mus musculus, Rattus norvegicus
C601AIAFSCLGILV3Homo sapiens, Mus musculus, Rattus norvegicus
F639ILAGIFLGYVC3Homo sapiens, Mus musculus, Rattus norvegicus
F646GYVCPFTLIAK3Homo sapiens, Mus musculus, Rattus norvegicus
F801IIWLAFVPIYF3Homo sapiens, Mus musculus, Rattus norvegicus
G163GVIGPGSSSVA3Homo sapiens, Mus musculus, Rattus norvegicus
G319LIGSDGWADRD3Homo sapiens, Mus musculus, Rattus norvegicus
G665QRLLVGLSSAM3Homo sapiens, Mus musculus, Rattus norvegicus
I594SDIESIIAIAF2Mus musculus, Rattus norvegicus
I594SNIESIIAIAF1Homo sapiens
I597ESIIAIAFSCL3Homo sapiens, Mus musculus, Rattus norvegicus
I604FSCLGILVTLF3Homo sapiens, Mus musculus, Rattus norvegicus
I764YNGLLIMSCTY3Homo sapiens, Mus musculus, Rattus norvegicus
I797YTTCIIWLAFV3Homo sapiens, Mus musculus, Rattus norvegicus
I812GSNYKIITTCF3Homo sapiens, Mus musculus, Rattus norvegicus
K811FGSNYKIITTC3Homo sapiens, Mus musculus, Rattus norvegicus
L602IAFSCLGILVT3Homo sapiens, Mus musculus, Rattus norvegicus
L605SCLGILVTLFV3Homo sapiens, Mus musculus, Rattus norvegicus
L648VCPFTLIAKPT3Homo sapiens, Mus musculus, Rattus norvegicus
L659TTSCYLQRLLV3Homo sapiens, Mus musculus, Rattus norvegicus
L757GVVAPVGYNGL2Mus musculus, Rattus norvegicus
L757GVVAPLGYNGL1Homo sapiens
N760APVGYNGLLIM2Mus musculus, Rattus norvegicus
N760APLGYNGLLIM1Homo sapiens
P756LGVVAPVGYNG2Mus musculus, Rattus norvegicus
P756LGVVAPLGYNG1Homo sapiens
Q660TSCYLQRLLVG3Homo sapiens, Mus musculus, Rattus norvegicus
R661SCYLQRLLVGL3Homo sapiens, Mus musculus, Rattus norvegicus
S164VIGPGSSSVAI3Homo sapiens, Mus musculus, Rattus norvegicus
S165IGPGSSSVAIQ3Homo sapiens, Mus musculus, Rattus norvegicus
S186PQIAYSATSID3Homo sapiens, Mus musculus, Rattus norvegicus
S189AYSATSIDLSD3Homo sapiens, Mus musculus, Rattus norvegicus
S668LVGLSSAMCYS3Homo sapiens, Mus musculus, Rattus norvegicus
S822FAVSLSVTVAL3Homo sapiens, Mus musculus, Rattus norvegicus
T188IAYSATSIDLS3Homo sapiens, Mus musculus, Rattus norvegicus
T647YVCPFTLIAKP3Homo sapiens, Mus musculus, Rattus norvegicus
T653LIAKPTTTSCY3Homo sapiens, Mus musculus, Rattus norvegicus
T655AKPTTTSCYLQ3Homo sapiens, Mus musculus, Rattus norvegicus
T748YLICNTSNLGV3Homo sapiens, Mus musculus, Rattus norvegicus
T794FTMYTTCIIWL3Homo sapiens, Mus musculus, Rattus norvegicus
T815YKIITTCFAVS3Homo sapiens, Mus musculus, Rattus norvegicus
V643IFLGYVCPFTL3Homo sapiens, Mus musculus, Rattus norvegicus
V664LQRLLVGLSSA3Homo sapiens, Mus musculus, Rattus norvegicus
V753TSNLGVVAPVG2Mus musculus, Rattus norvegicus
V753TSNLGVVAPLG1Homo sapiens
W110IRDSCWHSSVA3Homo sapiens, Mus musculus, Rattus norvegicus
W588VRYLEWSNIES1Homo sapiens
W588IRYLEWSDIES1Mus musculus
W588VRYLEWSDIES1Rattus norvegicus
W798TTCIIWLAFVP3Homo sapiens, Mus musculus, Rattus norvegicus
Y236HTEGNYGESGM3Homo sapiens, Mus musculus, Rattus norvegicus
Y74EIREQYGIQRV3Homo sapiens, Mus musculus, Rattus norvegicus
Y805AFVPIYFGSNY3Homo sapiens, Mus musculus, Rattus norvegicus


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