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mutLBSgeneDB |
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| Gene summary for TBK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | TBK1 |
| Gene name | TANK-binding kinase 1 | |
| Synonyms | NAK|T2K | |
| Cytomap | UCSC genome browser: 12q14.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_013254.3, | |
| Description | NF-kB-activating kinaseNF-kappa-B-activating kinaseserine/threonine-protein kinase TBK1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 604834 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183735 | ||
| HPRD : 05322 | ||
| Vega : OTTHUMG00000168796 | ||
| Protein | UniProt: Q9UHD2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TBK1 | |
| BioGPS: 29110 | ||
| Pathway | NCI Pathway Interaction Database: TBK1 | |
| KEGG: TBK1 | ||
| REACTOME: TBK1 | ||
| Pathway Commons: TBK1 | ||
| Context | iHOP: TBK1 | |
| ligand binding site mutation search in PubMed: TBK1 | ||
| UCL Cancer Institute: TBK1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0032727 | positive regulation of interferon-alpha production | 16127453 | GO:0032728 | positive regulation of interferon-beta production | 16127453 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 16127453 |
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| Ligand binding site mutations for TBK1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R25 | R27S | BRCA | 1 | R25 | R25C | SKCM | 1 | P90 | P90S | SKCM | 1 | D157 | F158C | UCEC | 1 | R25 | R25C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TBK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R25 | R27S | -1.5519733 | P90 | P90S | -1.2303107 | D157 | F158C | -1.0140093 | R25 | R25C | -0.51694402 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TBK1 from PDB |
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| Differential gene expression and gene-gene network for TBK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TBK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TBK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TBK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4euu | A | D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4euu | B | D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4im3 | A | D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4iw0 | A | D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4iwp | A | D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4eut | A | P90 D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4eut | B | P90 D157 | 1FV | MRT67307 | N-{3-[(5-CYCLOPROPYL-2-{[3-(MORPHOLIN-4-YLMETHYL) PHENYL]AMINO}PYRIMIDIN-4-YL) AMINO]PROPYL}CYCLOBUTANECARBOXAMIDE | 4im0 | A | P90 D157 | BX7 | N-(3-{[5-IODO-4-({3-[(THIOPHEN-2-YLCARBONYL) AMINO]PROPYL}AMINO)PYRIMIDIN-2-YL]AMINO}PHENYL) PYRROLIDINE-1-CARBOXAMIDE | 4im2 | A | P90 D157 | 1H4 | N-{3-[(5-CYCLOPROPYL-2-{[3-(2-OXO-2,3-DIHYDRO-1H- PYRROL-1-YL)PHENYL]AMINO}PYRIMIDIN-4-YL) AMINO]PROPYL}CYCLOBUTANECARBOXAMIDE | 4iwo | A | P90 D157 | 1FV | MRT67307 | N-{3-[(5-CYCLOPROPYL-2-{[3-(MORPHOLIN-4-YLMETHYL) PHENYL]AMINO}PYRIMIDIN-4-YL) AMINO]PROPYL}CYCLOBUTANECARBOXAMIDE | 4iwq | A | R25 P90 |
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| Conservation information for LBS of TBK1 |
| Multiple alignments for Q9UHD2 in multiple species |
| LBS | AA sequence | # species | Species |
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