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mutLBSgeneDB |
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| Gene summary for GRM3 |
 Gene summary |
| Basic gene Info. | Gene symbol | GRM3 |
| Gene name | glutamate receptor, metabotropic 3 | |
| Synonyms | GLUR3|GPRC1C|MGLUR3|mGlu3 | |
| Cytomap | UCSC genome browser: 7q21.1-q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000840.2, | |
| Description | glutamate metabotropic receptor 3metabotropic glutamate receptor 3 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 601115 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198822 | ||
| HPRD : 03070 | ||
| Vega : OTTHUMG00000022884 | ||
| Protein | UniProt: Q14832 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRM3 | |
| BioGPS: 2913 | ||
| Pathway | NCI Pathway Interaction Database: GRM3 | |
| KEGG: GRM3 | ||
| REACTOME: GRM3 | ||
| Pathway Commons: GRM3 | ||
| Context | iHOP: GRM3 | |
| ligand binding site mutation search in PubMed: GRM3 | ||
| UCL Cancer Institute: GRM3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for GRM3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T174 | A176T | BRCA | 1 | R64 | G65R | HNSC | 1 | Y222 | G223R | HNSC | 1 | T174 | S175R | HNSC | 1 | A172 | Y171N | LUAD | 1 | K389 | S388Y | LUSC | 1 | T174 | A176T | PRAD | 1 | I79 | E78K | SKCM | 1 | D82 | D82N | SKCM | 1 | Y222 | G223E | SKCM | 1 | R64 | R64Q | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GRM3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A172 | Y171N | -1.1427181 | I79 | E78K | -0.83789353 | R64 | R64Q | -0.81039126 | D82 | D82N | -0.70538624 | K389 | S388Y | -0.6560961 | R64 | G65R | -0.58179763 | T174 | A176T | -0.4433092 | Y222 | G223R | -0.37847154 | Y222 | G223E | -0.32952193 | T174 | S175R | -0.070212843 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GRM3 from PDB |
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| Differential gene expression and gene-gene network for GRM3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GRM3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0036341 | Schizophrenia | 35 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0025202 | Melanoma | 2 | Biomarker |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GRM3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Investigational | DB05096 | LY2140023 | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GRM3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 5cnm | A | I79 D82 | 52Q | (1R,2S,4R,5R,6R)-2-AMINO-4-(1H-1,2,4-TRIAZOL-3- YLSULFANYL)BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID | 5cnm | A | R64 A172 T174 K389 | 40F | (1S,2S,5R,6S)-2-AMINOBICYCLO[3.1.0]HEXANE-2,6- DICARBOXYLIC ACID | 4xar | A | R64 A172 T174 Y222 K389 | GGL | L-GLUTAMIC ACID RESIDUE | 5cnk | A | R64 A172 T174 Y222 K389 |
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| Conservation information for LBS of GRM3 |
| Multiple alignments for Q14832 in multiple species |
| LBS | AA sequence | # species | Species | A172 | PQISYASTSAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A172 | PQVSPASTAKT | 1 | Drosophila melanogaster | D194 | RTVPPDFYQAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D194 | RTVPPDTFQSV | 1 | Drosophila melanogaster | D301 | TWVASDGWGAQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D301 | HWIASDGWGKQ | 1 | Drosophila melanogaster | D82 | DEINKDNYLLP | 2 | Mus musculus, Rattus norvegicus | D82 | DEINKDDYLLP | 1 | Homo sapiens | D82 | DRVNNDPNILP | 1 | Drosophila melanogaster | G302 | WVASDGWGAQE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G302 | WIASDGWGKQQ | 1 | Drosophila melanogaster | I79 | FAIDEINKDNY | 2 | Mus musculus, Rattus norvegicus | I79 | FAIDEINKDDY | 1 | Homo sapiens | I79 | YAIDRVNNDPN | 1 | Drosophila melanogaster | K389 | YEQESKIMFVV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K389 | YEQESKTQFVV | 1 | Drosophila melanogaster | L85 | NKDNYLLPGVK | 2 | Mus musculus, Rattus norvegicus | L85 | NKDDYLLPGVK | 1 | Homo sapiens | L85 | NNDPNILPGIT | 1 | Drosophila melanogaster | L86 | KDNYLLPGVKL | 2 | Mus musculus, Rattus norvegicus | L86 | KDDYLLPGVKL | 1 | Homo sapiens | L86 | NDPNILPGITI | 1 | Drosophila melanogaster | R64 | RINEDRGIQRL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R64 | PKVYNRGVQRL | 1 | Drosophila melanogaster | R68 | DRGIQRLEAML | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R68 | NRGVQRLEAML | 1 | Drosophila melanogaster | S149 | GVIGGSYSSVS | 4 | Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus | S151 | IGGSYSSVSIQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S151 | IGGSYSSVSLQ | 1 | Drosophila melanogaster | S173 | QISYASTSAKL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S173 | QVSPASTAKTL | 1 | Drosophila melanogaster | T174 | ISYASTSAKLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T174 | VSPASTAKTLS | 1 | Drosophila melanogaster | Y150 | VIGGSYSSVSI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y150 | VIGGSYSSVSL | 1 | Drosophila melanogaster | Y222 | ASEGDYGETGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y222 | HSEGSYGEYGI | 1 | Drosophila melanogaster |
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